Metabolic activity of neutrophils and monocytes in the peripheral blood at the viral hepatitis C

Alan Tskhovrebov; Lyudmila Plakhtiy; E. Gatieva; Armila Tadeeva

doi:doi:10.12737/17132

Metabolic activity of neutrophils and monocytes in the peripheral blood at the viral hepatitis C

Published в Vladikavkaz Medico-Biological Bulletin · Volume 21, Issue 31, 2015 · Pages 14–18 · Rubrics: Problems of physiology and pathology of visceral systems

DOI 10.12737/17132

Received: 05.01.2016 Accepted: 05.01.2016 Published: 05.01.2016 Language of publication: RUS

Authors

Alan Tskhovrebov · Lyudmila Plakhtiy · E. Gatieva · Armila Tadeeva

ABSTRACT

Survey of 67 patients with viral hepatitis C was made. Of these comorbidities were identified in 11 patients. The survey was conducted at the height of clinical manifestations, in the waning of clinical symptoms in early convalescence. The control group consisted of 27 healthy individuals. In patients with hepatitis C dysfunction of neutrophils and monocyteswas revealed. These changescorrelate with the severity of the process. A consequence of the metabolic defect is a decrease in phagocytic activity of neutrophils and monocytes, which allows to offer methods of studying the metabolism of peripheral blood phagocytes as additional criteria to assess the severity of the disease, the prognosis of viral Hepatitis C, its outcomes and complications.

KEYWORDS

viral Hepatitis C NST-test monocytes neutrophils.

Information Text References

Authors:

Type:

Article

Pages:

from 14 to 18

Status:

Published

Language:

Russian

Keywords:

viral Hepatitis C, NST-test, monocytes, neutrophils.

Text

Гепатит С официально стал регистрироваться с 1994 года [8] и клинические проявления его в мировой литературе освещены довольно подробно [1, 6, 7]. Частота регистрации гепатита С зависит от набора используемых тест-систем, диагностических критериев и представлена в достаточно широком диапазоне, но при этом есть единичные работы, которые касаются иммунитета при остром вирусном гепатите С [1–4]. Известно, что в патогенезе гепатита С важную роль играют иммуноопосредованные еханизмы. Однако, этот вопрос нуждается в дальнейшем изучении и уточнении. Не исследовано метаболическое состояние фагоцитирующих клеток периферической крови у больных вирусным гепатитом С.

References

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3. Pak S. G., Voltchkova E. V., Umbetova K. T. Humoral and cellular adaptive mechanisms in the development of intoxication syndrome in patients with acute viral hepatitis. Therapeutic archive. 2004; 76(11): 61-5.

4. Podymova S. D. Parenteral acute viral hepatitis: modern diagnostics, prevention and treatment. Experimental and clinical gastroenterology. 2012; 6: 76-85.

5. Plahtiy L. Y., Gatiev E. I., Tskhovrebov A. C. The method study of metabolic activity of phagocytes by NBT test. Patent number 2492484 from 10.06.2013. Byulleten. 2013; 25.

6. Stozhakov G. I., Nikitin I. G., Baykova I. E. Acute hepatitis C in practice therapist. Russian Medical Journal.2005; 5: 46.

7. Suranbaeva G. S., Murzakulova A. B., Anarbaeva J. A. et al. Nosocomial acute viral hepatitis C. Kazan Journal of Medicine. 2014; 95(5): 744-7.

8. Trifonova G. F., Levakova I. A., Bolsun D. D. et al. Acute and chronic hepatitis C in the Russian Federation in 1994-2013 years. Infection and Immunity. 2014; 4(3): 267-74.

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Metabolic activity of neutrophils and monocytes in the peripheral blood at the viral hepatitis C

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