Labor pain can be the cause of the innate immunity factor, for example activity of lysozyme. It is the purpose of this research.Normative term labor in rats and labor with preceding electrical painful stimulation were accompanied with increase of lysozyme activity in the blood. The level of lysozyme activity was increased earlier and persisted longer in rats with painful irritation.
lysozyme, pregnancy, labor, pain.
Введение
Лизоцим – один из наиболее изученных гуморальных факторов врожденного иммунитета. Его бактериоцидные свойства не вызывают сомнения. В семидесятые годы ушедшего века опытным путем было доказано, что элиминация лизоцима из крови лишает ее на 40% бактериоцидности [16]. По уровню лизоцима принято судить о состоянии неспецифической резистентности организма в целом [2]. Продукция лизоцима нейтрофилами, макрофагами зависит не только от инфекционного раздражения, но и от раздражителей неантигенной природы [10, 14]. Показано, что в ответ на болевое раздражение активность лизоцима возрастала в крови крыс [1, 13]. Родовая боль не исключение, она может оказаться причиной активации и лизоцима, и других факторов врожденного иммунитета, но это требует доказательства, чему и посвящено настоящее исследование.
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