CLINICAL MANIFESTATION OF RADIATION-EXPOSED TUBERCULOSIS WHEN URANIUM PRODUCTION
Abstract and keywords
Abstract (English):
Present study was performed in Krasnokamensk city. We conducted retrospective study of 34 incident cases of tuberculosis (TB) among employees of the Priargunsky Industrial Mining and Chemical Union exposed to radiation (uranium production and processing). The comparison group included 47 TB patients, permanent residents of Krasnokamensk. The study found out that long-term dynamics of TB morbidity in the main group exceeded the one of the comparison group. Among the employees, most cases were registered in the 20–35 age group (47.0 %), and among the Krasnokamensk residents – in the 35–50 age group (51.0 %). In the main group, the most common cases were gross and extrapulmonary forms of tuberculosis (53.0 % and 14.7 % respectively). In the comparison group, minor TB forms dominated (59.5 %) and only one case of extrapulmonary tuberculosis was registered (p < 0.05). The effectiveness of the treatment in compared groups did not differ.

Keywords:
tuberculosis, clinical course, uranium ore, radon, radiation exposure
References

1. Buldakov LA (1990). Radioactive agents and a man [Radioaktivnye veshchestva i chelovek], 160.

2. Golovanev SM (2015). Radon and carcinogenic risk in Moscow [Radon i kantserogennyy risk v g. Moskva]. Radiatsionnaya gigiena, 8 (1), 16-20.

3. Zueva LP, Yafaev RH, Eremin SR (2003). Epidemiological diagnosis [Epidemiologicheskaya diagnostika], 264.

4. Kalechits OM, Al’khimovich VA (1990). Tuberculosis and the Chernobyl disaster. State and prognosis [Tuberkulez i chernobyl’skaya tragediya Sostoyanie i prognoz]. Problemy tuberkuleza, (11), 14-19.

5. Karpov AB, Semenova YuV, Takhauov RM, Litvinenko TM, Popov SV, Leonov VP (2005). The role of low doses of ionizing radiation in the development of non-oncological effects: hypothesis or reality? [Rol’ «malykh» doz ioniziruyushchego oblucheniya v razvitii neonkologicheskikh effektov: gipoteza ili real’nost’?]. Byulleten’ sibirskoj mediciny, (2), 63-70.

6. Makarov OA, Savchenkov MF, Ilyin VP, Kolesnikov LI (2000). Radon and health population [Radon i zdorov’e naseleniya], 147.

7. Malashenko AV, Nakatis YaA (2012). Problems of pathogenesis of occupational pulmonary pathology in uranium mineworkers [Voprosy patogeneza professional’noy legochnoy patologii u gornorabochikh uranovykh shakht]. Meditsina ekstremal’nykh situatsiy, (2), 28-34.

8. Marennyy AM, Kiselev SM, Titov AV, Zolotukhina SB, Astafurov VI, Dmitriev VA, Zhuravleva LA, Marenny MA, Nefedov NA, Penezev AV, Khokhlova EA (2013). Indoor radon management in Krasnokamensk city [Obsledovanie g. Krasnokamensk na soderzhanie radona v pomeshcheniyakh]. Radiatsionnaya gigiena, 6 (3), 47-52.

9. Moskalev YuI (1991). Remote effects of ionizing radiation [Otdalennye posledstviya vozdeystviya ioniziruyushchikh izlucheniy], 464.

10. Nenakhova EV, Makarov OA, Chernyago BP, Sinitskiy EA, Minaev EA (2006). Hygienic indoor hazard assessment of radon in the Baikal Region [Gigienicheskaya ocenka opasnosti radona v zhilyh pomeshcheniyah na territorii Pribajkal’ya]. Byul. VSNTs SO RAMN, (6), 191-193.

11. Nenakhova EV, Makarov OA (2006). Radon and health of population [Radon i zdorov’e naseleniya]. Byul. VSNTs SO RAMN, (6), 184-185.

12. Ovseychuk VA, Alekseev ON (2009). Radiation protection of stope miners in uranium deposit exploitation [Predokhranenie gornorabochego ochistnogo zaboya ot radioaktivnogo oblucheniya pri razrabotke uranovykh mestorozhdeniy]. Vestnik Chitinskogo gosudarstvennogo universiteta, 3 (54), 19-23.

13. Savilov ED, Astaf’ev VA, Zhdanova SN, Zarudnev EA (2011). Epidemiological analysis. Methods of statistical data analysis [Epidemiologicheskiy analiz. Metody statisticheskoy obrabotki materiala], 156.

14. Tikhonov MN (2008). Radon radiation: sources, doses and unresolved problems [Radonovaya radiatsiya: istochniki, dozy i nereshennye voprosy]. Ekologiya promyshlennogo proizvodstva, (1), 35-51.

15. Tikhonov MN (2010). Consequences of public exposure to radon radiation [Posledstviya oblucheniya naseleniya radonom]. Ekologiya promyshlennogo proizvodstva, (2), 22-31.

16. Tikhonov MN (2011). Effect of small doses of ionizing radiation on human health [Vliyanie malykh doz ioniziruyushchey radiatsii na zdorov’e cheloveka]. Ehkologiya promyshlennogo proizvodstva, (2), 27-39.

17. Uyba VV, Kiselev MF, Romanov VV, Shandala EK, Khokhlova EA (2009). Public safety problems on the territories with natural and anthropogenic factors of radiation on the example of zone of influence the Priargunsky Industrial Mining and Chemical Union [Problemy bezopasnosti naseleniya na territoriyakh s prirodnymi i tekhnogennymi faktorami radiatsii na primere rayona vliyaniya Priargunskogo gorno-khimicheskogo kombinata]. Biosfera, 1 (1), 101-105.

18. Shubik VM, Ivanov EV, Kashin VN, Kopoyanin VA (2009). Experience of health examination of people exposed to radon [Opyt izucheniya zdorov’ya pri vozdeystvii radona]. Radiatsionnaya gigiena, 2 (4), 27-33.

19. Cohen BL (1993). Relationship between exposure to radon and various types of cancer. Health Phys., 65 (5), 529-531.

20. Peto J, Darby S (1994). Lung cancer – radon risk reassessed. Nature, (368), 97-98.

21. Steindonf K, Lubir J, Wichmann HE, Becher H (1995). Lung cancer deaths attributable to indoor Radon exposure in West Germany. Intern J. Epidemiol., 24 (3), 485-492.

22. Trupin L, Earnest G, SanPedro M et al. (2003). The occupational burden of chronic obstructive pulmonary disease. Eur. Respir. J., (22), 462-469.

Login or Create
* Forgot password?