Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
There is no uniform method to conduct the epidemiological monitoring of BCG complications in the Russian Federation. Current indicators of BCG complications include the number of complication cases (cases registered within two years after vaccination) and the total number of the vaccinated children. Our aim is to discover a new indicator of BCG complications and to compare it with the indicators of the existing methods. The comparative analysis of new and existing methods of all complication cases (continuous sampling, n = 110) was conducted in the Irkutsk Region (Eastern Siberia) from 2005 to 2014. The calculating formula included the ratio of the number of children with complications vaccinated in the analyzed year to 100,000 children vaccinated in the same year. The new method shows the advantages over the existing methodological approaches. It demonstrates more adequate assessment, expressed in the highest approximation coefficient of trend model compared to the other methods, and stability of indicator over the years. The incidence of complications in the Irkutsk Region has a steady decreasing linear trend and a significant negative growth rate of the indicator (–17.9 %). The new method offers an adequate assessment and can be used as an epidemiological control system not only in the Russian Federation but in other high TB-burden countries with massive BCG vaccination of children.
BCG v accination, complication, epidemiological indicator
1. Aksenova VA, Mushkin AY, Kovalenko KN, Kul’mina EA, Babkin MN, Isaeva NY, Fonina EV (2007). BCG osteitis in children: epidemiological indicators of some regions of the Russian Federation [BTsZh-ostity u detey: epidemiologicheskie pokazateli nekotorykh regionov Rossiyskoy Federatsii]. Tuberkulez i bolezni legkikh, 84 (1), 9-12.
2. Aksenova VA, Levi DT (2012). Tuberculosis in children and teenagers [Tuberkulez u detey i podrostkov]. Biopreparaty. Profilaktika. Diagnostika. Lechenie, (1), 22-27.
3. Koretskaya NM (2011). Modern views on the BCG vaccination [Sovremennye vzglyady na vaktsinatsiyu BTsZh]. Sibirskoe meditsinskoe obozrenie, (1), 3-8.
4. Lyamina EL, Rogozhina NA, Gryzunova VN, Rogozhin AYu (2008). Complications of primary BCG vaccination under modern conditions [Oslozhneniya pervichnoy BTsZh-vaktsinatsii v sovremennykh usloviyakh]. Zdorov’e i obrazovanie v 21 veke, 10 (11), 460.
5. Savilov ED, Astaf’ev VA, Zhdanova SN, Zarudnev EA (2011). Epidemiological analysis: Methods of statistical processing of data [Epidemiologicheskiy analiz: Metody statisticheskoy obrabotki materiala], 156.
6. Sevost’yanova TA, Levi DT, Aleksandrova NV, Aksenova VA (2013). Analysis of the causes of BCG vaccination complications [Analiz prichin oslozhneniy posle vaktsinatsii BTsZh]. Tuberkulez i bolezni legkikh, 90 (6), 80-81.
7. Sevost’yanova TA, Gordina AV, Sterlikov SA, Aksenova VA (2013). Completeness of the registration of patients with BCG complications in different subjects of the Russian Federation [Polnota registratsii bol’nykh s oslozhnenennym techeniem vaktsinatsii BTsZh v razlichnykh sub”ektakh Rossiyskoy Federatsii]. Tuberkulez i bolezni legkikh, 90 (6), 78-80.
8. Khokholov YA, Ozerkovskiy NA, Snegireva II, Zatolochina KE (2012). Osteitis in children after BCG vaccination [Ostity u detey posle vaktsinatsii protiv tuberkuleza]. Rossiyskiy meditsinskiy zhurnal, (6), 17-20.
9. Shilova MV (2014). Tuberculosis in Russia in 2012–2013 [Tuberkulez v Rossii v 2012–2013 godu], 244.
10. Rea L, Parker R (2014). Designing and conducting research, 360.
