PATHOGENETIC MARKERS OF ECOLOGICALLY RELATED RESPIRATORY DISEASES

Tatyana Vitkina; Lyudmila V. Veremchuk; Irina Simonova; Tatyana Gvozdenko; Marina V. Antonyuk

doi:doi:10.12737/23112

PATHOGENETIC MARKERS OF ECOLOGICALLY RELATED RESPIRATORY DISEASES

Published в Bulletin physiology and pathology of respiration · Volume 1, Issue 62, 2016 · Pages 8–15 · Rubrics: ORIGINAL RESEARCH

DOI 10.12737/23112

Received: 06.12.2016 Accepted: 15.12.2016 Published: 15.12.2016 Language of publication: RUS

Authors

Tatyana Vitkina ¹ · Lyudmila V. Veremchuk ² · Irina Simonova · Tatyana Gvozdenko ⁴ · Marina V. Antonyuk ⁵

1 Nauchno-issledovatel'skiy institut medicinskoy klimatologii i vosstanovitel'nogo lecheniya (laboratoriya medicinskoy ekologii i rekreacionnyh resursov, zaveduyuschaya)
Vladivostok, Vladivostok, Russian Federation

2 Research Institute of Medical Climatology and Rehabilitative Treatment (laboratoriya medicinskoy ekologii i rekreacionnyh resursov, veduschiy nauchnyy sotrudnik)
Vladivostok, Vladivostok, Russian Federation

4 Nauchno-issledovatel'skiy institut medicinskoy klimatologii i vosstanovitel'nogo lecheniya (direktor)
Vladivostok, Vladivostok, Russian Federation

5 Vladivostokskiy filial Federal'nogo gosudarstvennogo byudzhetnogo nauchnogo uchrezhdeniya «Dal'nevostochnyy nauchnyy centr fiziologii i patologii dyhaniya» – Nauchno-issledovatel'skiy institut medicinskoy klimatologii i vosstanovitel'nogo lecheniya
Vladivostok, Vladivostok, Russian Federation

ABSTRACT

The aim of the research is to examine the relationship between the integral parameters of respiratory function, the values of LPO-AOD system and NO level at bronchopulmonary pathology in individuals living in different ecological areas of the city of Vladivostok. 206 patients living in different ecological conditions (healthy individuals, patients with respiratory disorders) were examined. Lung function and the state of LPO-AOD system were studied; the concentration of NO metabolites was assessed in blood serum. The nature and strength of the impact of environmental factors on respiratory function, the state of LPO-AOD, NO level were studied by the method based on correlation analysis. There was calculated power index (D) which was differentiated into power within the system (Ds) which in its turn reflects the in-system interrelationship tension (LPO-AOD, respiratory) and power between systems (Dm) characterizing the activity of interconnections and response to an external stimulus. Intra-system dependences typical for the unfavorable zone were viewed in relation to the favorable zone. It was found out that in ecologically unfavorable regions in individuals with different bronchopulmonary pathologies the value of Ds increases. This indicates that the pathogenic influence of environmental factors increases. In healthy people living in ecologically unfavourable area physiological adaptive-compensatory reaction of the body was revealed, which was proved by high power interconnections (Dm). In the patients with chronic bronchitis there was maintained an adequate level of functioning of the body systems studied. In patients with COPD living in an unfavourable zone there were found strong links between the indicators of the system of LPO-AOD and of NO, and in patients with bronchial asthma - supplementary relationship between lung function and NO. At the same time pathologic changes in the system of LPO-AOD and NO depend on the general pollution, metal and gas components contained in the air. Thus, the people with respiratory diseases being in environmentally unfavorable conditions have the most negative influence. The analysis of the activity of relationships proved that violations of interaction of LPO-AOD systems and NO in ecologically unfavorable regions may contribute to the occurrence and progression of bronchopulmonary diseases.

KEYWORDS

lipid peroxidation and antioxidant system nitric oxide respiratory pathology ecologically unfavourable environment.

Information References

Authors:

1. Nauchno-issledovatel'skiy institut medicinskoy klimatologii i vosstanovitel'nogo lecheniya (laboratoriya medicinskoy ekologii i rekreacionnyh resursov, zaveduyuschaya)

Vladivostok, Vladivostok, Russian Federation

2. Research Institute of Medical Climatology and Rehabilitative Treatment (laboratoriya medicinskoy ekologii i rekreacionnyh resursov, veduschiy nauchnyy sotrudnik)

Vladivostok, Vladivostok, Russian Federation

4. Nauchno-issledovatel'skiy institut medicinskoy klimatologii i vosstanovitel'nogo lecheniya (direktor)

Vladivostok, Vladivostok, Russian Federation

5. Vladivostokskiy filial Federal'nogo gosudarstvennogo byudzhetnogo nauchnogo uchrezhdeniya «Dal'nevostochnyy nauchnyy centr fiziologii i patologii dyhaniya» – Nauchno-issledovatel'skiy institut medicinskoy klimatologii i vosstanovitel'nogo lecheniya

Vladivostok, Vladivostok, Russian Federation

Type:

Article

Pages:

from 8 to 15

Status:

Published

Language:

Russian

Keywords:

lipid peroxidation and antioxidant system, nitric oxide, respiratory pathology, ecologically unfavourable environment.

References

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