Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveshchensk, Blagoveshchensk, Russian Federation
Modern environmental conditions dramatically increased the level of radical forming processes in the body. Heat exposure stimulates the generation of reactive oxygen species inducing peroxidation of lipids as a result of the development of hypoxia. In experimental conditions the possibility to correct free radical lipid oxidation of rats’ organism membranes was studied with the oral introduction of the phytoadaptogens that contain the complex of natural antioxidants. The animals were divided into 5 groups and each of them had 30 rats: intact animals (1) which were held in standard conditions of vivarium; the control group (2) in which rats were exposed to heat during forty-five minutes daily; the experimental groups (3, 4, 5) in which before the effects of heat animals had a daily oral intake of the extracts of Eleutherococcus, Rhodiola, liquorice in a dose of 1 ml/kg. It was found out that in the liver tissue of experimental animals a daily heat exposure during forty-five minutes contributes to the increase of lipid hydroperoxides level (by 34-41%), of diene conjugate (by 45-50%), and of malonic dialdehyde (by 62-74%) against the decrease of antioxidant system activity in the liver of intact animals. The introduction of phytoadaptogens to rats in the conditions of heat exposure contributes to the reliable decrease in the liver of lipid hydroperoxides by 22-28%, of diene conjugates by 22-32%, and of malonic dialdehyde by 30-37% in comparison with the rats of the control group. While analyzing the effect of the phytoadaptogens on the activity of the components of antioxidant system it was shown that the level of ceruloplasmin in the liver of animals was reliably higher by 68-82%, of vitamin E by 42-65% in comparison with the same parameters of the rats of the control group. So, the application of phytoadaptogens in the conditions of long heat exposure of the organism of animals under experiment leads to the stabilization of the processes of peroxidation against the increase of antioxidant system activity.
phytoadaptogens, extract eleutherococcus, extract rhodiola rosea, extract liquorice, heat exposure, biological membranes lipid peroxidation, products of peroxidation (lipid hydroperoxides, diene conjugates, malonic dialdehyde), antioxidant system.
1. Bacherikov A.N., Kuz´minov V.N., Tkachenko T.V., Nazarchuk A.G. Modern conceptions about the system of thermoregulation. Vestnik psikhiatrii i psikhofarmakoterapii 2006; 1:178–182 (in Russian).
2. Bystrova N.A. Immunometabolic effects of moderately high ambient temperature. In: Abstracts of the VIII Russian national congress "Man and medicine". Moscow; 2001: 551 (in Russian).
3. Dorovskikh V.A., Simonova N.V., Simonova I.V., Shtarberg M.A. Adaptogens of vegetable origin in prophylaxis of respiratory diseases in children of young age. Dal´nevostochnyy meditsinskiy zhurnal 2011; 1:41–44 (in Russian).
4. Dorovskikh V.A., Simonova N.V., Li O.N., Dorovskikh V.Yu., Shtarberg M.A., Landyshev S.Yu., Mishuk V.P., Savinova T.A. Effect of succinate containing drugs on the intensity of peroxidation in the conditions of cold exposure. Bûlleten´ fiziologii i patologii dyhaniâ 2013; 50:56–60 (in Russian).
5. Dorovskikh V.A., Simonova N.V., Dorovskikh Yu.V., Li O.N. Correction of cold effect by means of the drug with succinic acid. Bûlleten´ fiziologii i patologii dyhaniâ 2013; 49:82–86 (in Russian).
6. Dorovskikh V.A., Tseluyko S.S., Simonova N.V., Anokhina R.A. In the world of antioxidants. Blagoveshchensk: AGMA; 2012 (in Russian).
7. Simonova N.V., Dorovskikh V.A., Shtarberg M.A. Effect of the tincture made of nettle, birch and plantain leaves on the intensity of peroxidation at ultraviolet radiation. Bûlleten´ fiziologii i patologii dyhaniâ 2012; 44:90–94 (in Russian).
8. Simonova N.V., Dorovskikh V.A., Shtarberg M.A. The influence of vegetal adaptogens on the intensity of lipid peroxidation processes of biomembranes during ultraviolet irradiation. Dal´nevostochnyy meditsinskiy zhurnal 2010; 2:112–115 (in Russian).
9. Simonova N.V., Dorovskikh V.A., Simonova N.P. Ultraviolet radiation and oxidative stress. The possibility of phitocorrection. Blagoveshchensk: Dal´GAU; 2014 (in Russian).
10. Simonova N.V., Dorovskikh V.A., Li O.N., Shtarberg M.A., Simonova N.P. Tincture of medicinal plants and oxidative stress in the conditions of cold influence. Bûlleten´ fiziologii i patologii dyhaniâ 2013; 48:76–80 (in Russian).
