High prevalence of genotype B0/W148 of Mycobacterium tuberculosisamong hiv-tB patients in perm krai and irkutsk region

Oleg Ogarkov; Evgeniy Savilov; Polina Khromova; Olga N. Novitskaya; Tatyana Varetskaya; Evgeniy Sarmometov; Viktor Sergevnin; Svetlana Zhdanova; Oksana Mikova; Mikhail Koshcheev; Dmitriy Shmagin

doi:doi:10.12737/23412

High prevalence of genotype B0/W148 of Mycobacterium tuberculosisamong hiv-tB patients in perm krai and irkutsk region

Published в Acta biomedica scientifica · Volume 1, Issue 5, p. 2, 2016 · Pages 142–145 · Rubrics: Epidemiology

DOI 10.12737/23412

Received: 11.12.2016 Accepted: 11.12.2016 Published: 11.12.2016 Language of publication: RUS

Authors

Oleg Ogarkov ¹ · Evgeniy Savilov · Polina Khromova · Olga N. Novitskaya ⁴ · Tatyana Varetskaya · Evgeniy Sarmometov · Viktor Sergevnin · Svetlana Zhdanova ⁸ · Oksana Mikova · Mikhail Koshcheev · Dmitriy Shmagin

1 Irkutsk State Medical Academy of Postgraduate Education (Central Research Laboratory, Research Officer)
Irkutsk, Irkutsk region, Russian Federation

4 Russian Federation

8 Scientific Centre for Family Health and Human Reproduction Problems (Laboratory of Epidemiologically and Socially Significant Infections, Senior Research Officer)
Irkutsk, Irkutsk region, Russian Federation

ABSTRACT

The population with HIV-infection plays significant role in ongoing tuberculosis pandemic. Immunosup-pression due to HIV-infection is one of the causes of TB disseminated forms in this group of people. Having low immune status is also often associated with a polyclonal M.tuberculosis infection. Aim of the research: comparative assessment of epidemic genotypes of M.tuberculosis prevalence and mixed genotypes identification within HIV-TB co-infected patients in two Russian regions.Materials and methods. The DNAs of 78 clinical isolates from Irkutsk Region (IR) and 64strains from Perm Krai (PK) have been genotyped by MIRU VNTR 24 and RD105/RD207. Strains were obtained from patients who did not have significant age and sex differences. In the PK age of the patients was 34.5±0.9, in IR – 34.4±1.5 years. The samples were obtained from 67.2 and 65.4% of men, respectively.Result. The study of the M.tuberculosis indicates significant predominance of Beijing genotype strains in patients with TB-HIV of PK (92.2%) compared to the IR (59.5%) (χ2=18.0; p<0.01). The prevalence of MDR pathogens in TB-HIV patients exceeded 50%. The mixed genotype detection in the PK and IR was high (14.1 and 12.7% respectively). The level of virulent strains B0/W148 was 34.4% in PK patients and 25.3% in IR ones. Analysis of the results suggests the epidemic spread of MDR-TB in the immunocompromised individuals.Conclusions: The identified trends may indicate that Perm Kray have a process of active dissemination of transmissible strains of M.tuberculosis within HIV-infected population.

KEYWORDS

tuberculosis genotype Beijing M.tuberculosis

Information References

Authors:

1. Irkutsk State Medical Academy of Postgraduate Education (Central Research Laboratory, Research Officer)

Irkutsk, Irkutsk region, Russian Federation

4. Russian Federation

8. Scientific Centre for Family Health and Human Reproduction Problems (Laboratory of Epidemiologically and Socially Significant Infections, Senior Research Officer)

Irkutsk, Irkutsk region, Russian Federation

Type:

Article

Pages:

from 142 to 145

Status:

Published

Language:

Russian

Keywords:

tuberculosis, genotype Beijing, M.tuberculosis

References

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