TO THE LETTER TO THE EDITOR OF S.V. JARGIN «ON THE RET/PTC REARRANGEMENTS IN THYROID CARCINOMA AFTER THE CHERNOBYL ACCIDENT»
Rubrics: DISCUSSION
Abstract and keywords
Abstract (English):
Privedennoe vyshe pis'mo predstavlyaet soboy otklik na nashe opublikovannoe v 2016 g. v «Medicinskaya radiologiya i radiacionnaya bezopasnost'» issledovanie (pooled-analiz) chastoty perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy (SchZh) dlya grupp lyudey iz razlichnyh stran mira (SNG – Rossiya, Belorussiya i Ukraina; Evropa, SShA + Kanada i Aziatsko-Tihookeanskiy region) v raznye periody posle avarii na Chernobyl'skoy atomnoy elektrostancii (ChAES).

Keywords:
gennye perestroyki RET/PTC, papillyarnaya karcinoma schitovidnoy zhelezy, sverhocenka posledstviy chernobyl'skoy avarii
Text

Приведенное выше письмо представляет собой отклик на наше опубликованное в 2016 г. в «Медицинская радиология и радиационная безопасность» исследование (pooled-анализ) частоты перестроек RET/PTC в папиллярных карциномах щитовидной железы (ЩЖ) для групп людей из различных стран мира (СНГ – Россия, Белоруссия и Украина; Европа, США + Канада и Азиатско-Тихоокеанский регион) в разные периоды после аварии на Чернобыльской атомной электростанции (ЧАЭС). Аналогичное письмо-отклик С.В. Яргина на нашу соответствующую работу 2016 г. по зависимостям доза–эффект для частоты RET/PTC было уже опубликовано в журнале «Радиационная биология. Радиэкология». Сходное письмо этого же автора направлялось в 2016 г. также и в «Саратовский научно-медицинский журнал» в ответ на нашу уже давнюю статью от 2013 г. по анализу частоты RET/PTC для радиобиологии и эпидемиологии. Это письмо С.В. Яргина журналом пока не опубликовано. Все «отклики» С.В. Яргина в целом аналогичны, развивают одни и те же представления («гипотезу», согласно его словам) и, местами, просто идентичны (смысл же и основные ссылки также во многом идентичны). Рассматриваемые проблемы являются узкими, специальными и, по внешнему виду, мало о чем могут говорить тому, кто не занимается именно генными перестройками RET/PTC.

References

1. Koterov A.N., Ushenkova L.N., Biryukov A.P., Samoylov A.S. Chastota gennyh perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy v stranah mira v zavisimosti ot vremeni posle avarii na Chernobyl'skoy atomnoy elektrostancii (pooled-analiz) // Med. radiol. i radiac. bezopasnost'. 2016. T. 61. № 2. S. 5–19.

2. Koterov A.N., Ushenkova L.N., Biryukov A.P., Samoilov A.S. RET/PTC gene rearrangements frequency in papillary thyroid carcinoma worldwide depending on time after Chernobyl Nuclear Power Plant accident (pooled-analysis). Possible contribution of factors of diagnosis, ‘aggressive surgery’, radiation and age // Med. radiol. i radiac. bezopasnost'. 2016. T. 61. № 5. S. 27–41.

3. Koterov A.N., Ushenkova L.N., Biryukov A.P. Zavisimosti doza–effekt dlya chastoty gennyh perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy posle oblucheniya. Ob'edinennyy analiz radiacionno-epidemiologicheskih dannyh // Radiac. biologiya. Radioekologiya. 2016. T. 56. № 1. S. 5–25.

4. Yargin S.V. Otklik na stat'yu: Koterov A.N., Ushenkova L.N., Biryukov A.P. Zavisimosti doza–effekt dlya chastoty gennyh perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy posle oblucheniya // Radiac. biologiya. Radioekologiya. 2016. T. 56. № 5. S. 542–544.

5. Ushenkova L.N., Koterov A.N., Biryukov A.P. Nepolnoe sootvetstvie eksperimental'nyh i epidemiologicheskih dannyh dlya chastoty gennoy perestroyki RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy primenitel'no k avarii na Chernobyl'skoy AES // Saratovskiy nauchno-med. zhurnal. 2013. T. 9. № 4. S. 795–801.

6. Yargin S.V. O preuvelichenii radiacionnyh posledstviy avarii na Chernobyl'skoy AES // Med. radiol. i radiac. bezopasnost'. 2007. T. 52. № 1. S. 73–74.

7. Yargin S.V. O preuvelichennyh posledstviyah avarii na ChAES: opuholi mochevogo puzyrya // Med. radiol. i radiac. bezopasnost'. 2007. T. 52. № 4. S. 83–84.

8. Yargin S.V. Nedostovernye publikacii o radiacionnom kancerogeneze v rayone Semipalatinska // Med. radiol. i radiac. bezopasnost'. 2007. T. 52. № 5. S. 73–74.

9. Yargin S.V. Preuvelichennaya ocenka medicinskih posledstviy povysheniya radiacionnogo fona // Med. radiol. i radiac. bezopasnost'. 2008. T. 53. № 3. S. 17–22.

10. Yargin S.V. O zavyshennoy ocenke zabolevaemosti rakom schitovidnoy zhelezy sredi lic, podvergshihsya v detskom vozraste radioaktivnomu oblucheniyu pri avarii na ChAES // Med. radiol. i radiac. bezopasnost'. 2010. T. 55. № 2. S. 65–69.

11. Yargin S.V. Lesnye pozhary v zagryaznennyh zonah // Med. radiol. i radiac. bezopasnost'. 2011. T. 56. № 3. S. 69–73.

12. Yargin S.V. K voprosu o zavyshennoy ocenke medicinskih posledstviy avarii na ChAES: prichiny i mehanizmy // Med. radiol. i radiac. bezopasnost'. 2011. T. 56. № 5. S. 74–79.

13. Yargin S.V. O radiacionno-inducirovannyh mutaciyah: otvet Yu.E. Dubrove // Med. radiol. i radiac. bezopasnost'. 2014. T. 59. № 4. S. 73–77.

14. Koterov A.N. Po povodu stat'i professora Yu. Dubrova «Izgnanie besov iz radiacionnoy biologii» (minisatellity) // Med. radiol. i radiac. bezopasnost'. 2005. T. 50. № 4. S. 60–73.

15. Koterov A.N. Radiacionno-inducirovannaya nestabil'nost' genoma pri deystvii malyh doz radiacii v nauchnyh publikaciyah i v dokumentah mezhdunarodnyh organizaciy poslednih let // Med. radiol. i radiac. bezopasnost'. 2009. T. 54. № 4. S. 5–13.

16. Jargin S.V. On the causes of insufficient restroom environmental hygiene in the former Soviet Union // Rev. Inst. Med. Trop. Sao Paulo. 2009. Vol. 51. № 6. P. 353.

17. Jargin S.V. On the RET rearrangements in Chernobyl-related thyroid cancer // J. Thyroid Res. 2012. Vol. 2012. Article ID 373879.

18. Jargin SV. Chernobyl-related cancer and precancerous lesions: incidence increase vs. late diagnostics //Dose Response. 2014. Vol. 12. № 3. P. 404–414.

19. Jargin S.V On the RET/PTC3 rearrangements in Chernobyl related thyroid cancer vs. late detection // International Journal of Cancer Research and Molecular Mechanisms. Int. J. Cancer Res. Mol. Mech. 2015. Vol. 1 (4): http://dx.doi.org/10.16966/2381-3318.117.

20. Yargin S.V. Zavisimost' gennyh perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy ot dlitel'nosti zabolevaniy i opuholevoy progressii // Mater. konf. «Aktual'nye problemy radiobiologii i astrobiologii. Geneticheskie i epigeneticheskie effekty ioniziruyuschih izlucheniy», Dubna, 9–11 noyabrya 2016 g. Dubna, 2016. S. 81–82.

21. Nikiforov Y.E., Rowland J.M., Bove K.E. et al. Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children // Cancer Res. 1997. Vol. 57. № 9. P. 1690–1694.

22. Romei C., Elisei R. RET/PTC translocations and clinico-pathological features in human papillary thyroid carcinoma // Front. Endocrinol. 2012. Vol. 3. Article 54. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356050/pdf/fendo-03-00054.pdf; data obrascheniya 12.01.2015).

23. Menicali E., Moretti S., Voce P. et al. Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma // Front. Endocrinol (Lausanne). 2012. Vol. 3. Article 67. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357465/pdf/fendo-03-00067.pdf; data obrascheniya 12.01.2015).

24. Ushenkova L.N., Koterov A.N., Biryukov A.P. Ob'edinennyy (pooled) analiz chastoty gennyh perestroek RET/PTC v spontannyh i radiogennyh papillyarnyh karcinomah schitovidnoy zhelezy // Radiac. biologiya. Radioekologiya. 2015. T. 55. № 4. S. 355–388.

25. Su X., Li Z., He C. et al. Radiation exposure, young age, and female gender are associated with high prevalence of RET/PTC1 and RET/PTC3 in papillary thyroid cancer: a meta-analysis // Oncotarget. 2016. Vol. 7. № 13. P. 16716–16730.

26. Ushenkova L.N., Koterov A.N., Biryukov A.P. Gennye perestroyki RET/PTC v spontannyh i radiogennyh opuholyah schitovidnoy zhelezy: molekulyarnaya genetika, radiobiologiya i molekulyarnaya epidemiologiya // Radiac. biologiya. Radioekologiya. 2015. T. 55. № 3. S. 229–249.

27. Yip L., Nikiforova M.N., Yoo J.Y. et al. Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients // Ann. Surg. 2015. Vol. 262. № 3. P. 519–525.

28. Hofmann B., Holm S., Iversen J.-G. Philosophy of science // In: ‘Research methodology in the medical and biological sciences’. Ed. by P. Laake, H.B. Benestad, B.R. Olsen. – Academic Press, Elsevier, 2007. P. 1–32.

29. Lushnikov E.F., Vtyurin B.M., Cyb A.F. Mikrokarcinoma schitovidnoy zhelezy. – M: Medicina, 2003. 264 s.

30. Viglietto G., Chiappetta G., Marchinez-Tello F.J. et al. RET-PTC oncogene activation is an early event in thyroid carcinogenesis // Oncogene. 1995. Vol. 11. № 6. P. 1207–1210.

31. Tallini G., Santoro M., Helie M. et al. RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes // Clin Cancer Res. 1998. Vol. 4. № 2. P. 287–294.

32. Sugg S.L., Ezzat Sh., Rosen I.B. et al. Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia // J. Clin. Endocrinol. Metab. 1998. Vol. 83. № 11. P. 4116–4122.

33. Corvi R., Martinez-Alfaro M., Harach H.R. et al. Frequent RET rearrangements in thyroid papillary microcarcinoma detected by interphase fluorescence in situ hybridization // Lab. Invest. 2001. Vol. 81. № 12. P. 1639–1645.

34. Zhang T., Lu Y., Ye Q. et al. An evaluation and recommendation of the optimal methodologies to detect RET gene rearrangements in papillary thyroid carcinoma // Genes Chromosomes Cancer. 2015. Vol. 54. № 3. P. 168–176.

35. Nikiforov Y.E., Nikiforova M.N. Molecular genetics and diagnosis of thyroid cancer // Nat. Rev. Endocrinol. 2011. Vol. 7. № 10. P. 569–580.

36. Mayr B., Brabant G., Goretzki P. et al. ret/PTC-1, -2, and -3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential? // J. Clin. Endocrinol. Metab. 1997. Vol. 82. № 4. P. 1306–1367.

37. Soares P., Fonseca E., Wynford-Thomas D., Sobrinho-Simoes M. Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms? // J. Pathol. 1998. Vol. 185. № 1. P. 71–78.

38. Mochizuki K., Kondo T., Nakazawa T. et al. RET rearrangements and BRAF mutation in undifferentiated thyroid carcinomas having papillary carcinoma components // Histopathology. 2010. Vol. 57. № 3. P. 444–450.

39. Rabes H.M., Demidchik E.P., Sidorow J.D. et al. Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-Shernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications // Clin. Cancer Res. 2000. Vol. 6. № 3. P. 1093–1103.

40. Bongarzone I., Vigneri P., Mariani L. et al. RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features // Clin. Cancer Res. 1998. Vol. 4. № 1. P. 223–228.

41. Rhoden K.J., Johnson C., Brandao G. et al. Real-time quantitative RT-PCR identifies distinct c-RET, RET/PTC1 and RET/PTC3 expression patterns in papillary thyroid carcinoma // Lab. Invest. 2004. Vol. 84. № 12. P. 1557–1570.

42. Jargin S.Vol. Thyroid cancer after chernobyl: obfuscated truth // Dose Response. 2011. Vol. 9. № 4. P. 471–476.

43. Nikiforov Y.E. Molecular diagnostics of thyroid tumors // Arch. Pathol. Lab. Med. 2011. Vol. 135. № 5. P. 569–577.

44. Rao P.J., Vardhini N.V., Parvathi M.V. et al. Prevalence of RET/PTC1 and RET/PTC3 gene rearrangements in Chennai population and its correlation with clinical parameters // Tumour Biol. 2014. Vol. 35. № 10. P. 9539–9548.

45. Di Cristofaro J., Vasko V., Savchenko V. et al. ret/PTC1 and ret/PTC3 in thyroid tumors from Chernobyl liquidators: comparison with sporadic tumors from Ukrainian and French patients // Endocr. Relat. Cancer. 2005. Vol. 12. № 1. P. 173–183.

46. Henderson Y.C., Shellenberger T.D., Williams M.D. et al. High rate of BRAF and RET/PTC dual mutations associated with recurrent papillary thyroid carcinoma // Clin. Cancer Res. 2009. Vol. 15. № 2. P. 485–491.

47. Moses W., Weng J., Khanafshar E. et al. Multiple genetic alterations in papillary thyroid cancer are associated with younger age at presentation // Surg. Res. 2010. Vol. 160. № 2. P. 179–183.

48. Cinti R., Yin L., Ilc K. et al. RET rearrangements in papillary thyroid carcinomas and adenomas detected by interphase FISH // Cytogenet. Cell Genet. 2000. Vol. 88. № 1–2. P. 56–61.

49. Elisei R., Romei C., Vorontsova T. et al. RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults // J. Clin. Endocrinol. Metab. 2001. Vol. 86. № 7. P. 3211–3216.

50. Basolo F., Giannini R., Monaco C. et al. Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma // Am. J. Pathol. 2002. Vol. 160. № 1. P. 247–254.

51. Guerra A., Marotta V., Di Stasi V. et al. Simultaneous occurrence of BRAF mutation and RET/PTC rearrangement is frequent in papillary thyroid carcinoma // Endocrine Abstracts. 2012. Vol. 29. P1787.

52. Guerra A., Zeppa P., Bifulco M., Vitale M. Concomitant BRAF(V600E) Mutation and RET/PTC rearrangement is a frequent occurrence in papillary thyroid carcinoma // Thyroid. 2014. Vol. 24. № 2. P. 254–259.

53. Hershman J.M. Concomitant BRAF Mutation and RET/PTC rearrangement occur in 19 % of papillary thyroid cancers // Clinical Thyroidology. 2014. Vol. 26. № 4. P. 109–110.

54. Kitamura Y., Minobe K., Nakata T. et al. RET/PTC3 is the most frequent form of gene rearrangement in papillary thyroid carcinomas in Japan // J. Hum. Genet. 1999. 44. № 2. P. 96–102.

55. Zhu X.L., Zhou X.Y., Zhu X.Z. BRAFV599E mutation and RET/PTC rearrangements in papillary thyroid carcinoma // Zhonghua Bing Li Xue Za Zhi. 2005. Vol. 34. № 5. P. 270–274.

56. Zhu Z., Ciampi R., Nikiforova M.N. et al. Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity // J. Clin. Endocrinol. Metab. 2006. Vol. 91. № 9. P. 3603–3610.

57. Liu R.-T., Chou F.-F., Wang C.-H. et al. Low prevalence of RET rearrangements (RET/PTC1, RET/PTC2, RET/PTC3, and ELKS-RET) in sporadic papillary thyroid carcinomas in Taiwan Chinese // Thyroid. 2005. Vol. 15. № 4. P. 326–335.

58. Wiench M., Wloch J., Oczko M. et al. Rearrangement of the RET gene in papillary thyroid carcinoma // Wiad. Lek. 2001. Vol. 54. Suppl 1. P. 64–71.

59. Erdogan M., Berdeli A., Karadeniz M. et al. The prevalence of RET/PTC mutations in papillary thyroid cancers in Turkish population and its relation between tumor histopathology and prognostic factors // Exp. Clin. Endocrinol. Diabetes. 2008 Vol. 116. № 4. P. 225–230.

60. UNSCEAR 2008. Report to the General Assembly, with Scientific Annex. Annex D. Health effects due to radiation from the Chernobyl accident. United Nations. New York, 2011. P. 47–219.

61. Likhtarov I., Kovgan L., Vavilov S. et al. Post-Chornobyl thyroid cancers in Ukraine. Report 1: estimation of thyroid doses // Radiat. Res. 2005. Vol. 163. № 2. P. 125–136.

62. Likhtarov I., Thomas G., Kovgan L. et al. Reconstruction of individual thyroid doses to the Ukrainian subjects enrolled in the Chernobyl Tissue Bank // Radiat. Prot. Dosimetry. 2013. Vol. 156. № 4. P. 407–423.

63. Jacob P., Bogdanova T., Buglova E. et al. Thyroid cancer risk in areas of Ukraine and Belarus affected by the Chernobyl accident // Radiat. Res. 2006. Vol. 165. № 1. P. 1–8.

64. Drozdovitch V., Minenko V., Khrouch V. et al. Thyroid dose estimates for a cohort of Belarusian children exposed to radiation from the Chernobyl accident // Radiat. Res. 2013. Vol. 179. № 5. P. 597–609.

65. Finn S.P., Smyth P., O’regan E. et al. Array comparative genomic hybridisation analysis of gamma-irradiated human thyrocytes // Virchows Arch. 2004. Vol. 445. № 4. P. 396–404.

66. Caudill C.M., Zhu Z., Ciampi R. et al. Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation // J. Clin. Endocrinol. Metab. 2005. Vol. 90. № 4. P. 364–369.

67. Yargin S.V. K voprosu o preuvelichenii posledstviy avarii na Chernobyl'skoy AES // Molodoy uchenyy. 2015. № 3. S. 351–358.

68. Prescott J.D., Zeiger M.A. The RET oncogene in papillary thyroid carcinoma // Cancer. 2015. Vol. 121. № 13. P. 2137–2146.

69. Rabes H. Gene Rearrangements in Radiation-Induced Thyroid Carcinogenesis // Med Pediatr Oncol. 2001. Vol. 36. № 5. P. 574–582.

70. Romei C., Fugazzola L., Puxeddu E. et al. Modifications in the papillary thyroid cancer gene profile over the last 15 years // J. Clin. Endocrinol. Metab. 2012. Vol. 97. № 9. P. E1758–E1765.

71. Agate L., Lorusso L., Elisei R. New and old knowledge on differentiated thyroid cancer epidemiology and risk factors // J. Endocrinol. Invest. 2012. Vol. 35. № 6. P. 3–9.

72. Jung C.K., Little M.P., Lubin J.H. et al. The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations // J. Clin. Endocrinol. Metab. 2014. Vol. 99. № 2. P. E276–E285.

73. Jargin S.V. On the tumor risk from dental diagnostic X-ray exposure // Ann. Oncol. 2016. Vol. 27. № 6. P. 1177.

74. Lin M.C., Lee C.F., Lin C.L. et al. Dental diagnostic X-ray exposure and risk of benign and malignant brain tumors // Ann. Oncol. 2013. Vol. 24. № 6. P. 1675–1679.

75. Hallquist A., Hardell L., Degerman A. et al. Medical diagnostic and therapeutic ionizing radiation and the risk for thyroid cancer: a case-control study // Eur. J. Cancer Prev. 1994. Vol. 3. № 3. P. 259–267.

76. Hallquist A., Nasman A. Medical diagnostic X-ray radiation--an evaluation from medical records and dentist cards in a case-control study of thyroid cancer in the northern medical region of Sweden // Eur. J. Cancer Prev. 2001. Vol. 10. № 2. P. 147–152.

77. Memon A., Godward S., Williams D. et al. Dental x-rays and the risk of thyroid cancer: a case-control study // Acta Oncol. 2010. Vol. 49. № 4. P. 447–453.

78. Hallquist A., Jansson P. Self-reported diagnostic X-ray investigation and data from medical records in case-control studies on thyroid cancer: evidence of recall bias? // Eur. J. Cancer Prev. 2005. Vol. 14. № 3. P. 271–276.

79. Kitahara C.M., Linet M.S., Rajaraman P. et al. A New Era of Low-Dose Radiation Epidemiology // Curr. Environ. Health Rep. 2015. Vol. 2. № 3. P. 236–249.

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