Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Cel': opredelit' chastoty genotipov i alleley polimorfnogo varianta 677S>T gena MTHFR sredi predstaviteley 2 nacional'nostey: russkih i buryat. Materialy i metody. Issledovano 399 detey i podrostkov (200 chelovek russkoy nacional'nosti, 199 – buryatskoy). V processe issledovaniya ispol'zovalis' molekulyarno-geneticheskie i statisticheskie metody. Rezul'taty. Chastota minornoy T-alleli dlya russkoy populyacii sostavila 30 %, dlya buryatskoy – 21,1 %. Mezhdu issledovannymi vyborkami vyyavleny statisticheski znachimye razlichiya rasprostranennosti T-alleli (r = 0,0041).
russkie, buryaty, genotipirovanie, MTHFR 677C>T, rasprostranennost'
1. Abaeva LL, Zhukovskaya NL (2004). Buryats [Buryaty], 634.
2. Bairova TA, Dolgikh VV, Bimbaev A, Tugutova IV (2005). The interrelation of methylenetetrahydrofolate reductase gene and essential hypertension in adolescents of different ethnic groups living in Buryatia [Vzaimosvyaz’ gena metilentetragidrofolatreduktazy i essentsial’noy arterial’noy gipertenzii u podrostkov raznykh etnicheskikh grupp, prozhivyushchikh na territorii Buryatii]. Byulleten Vostochno-Sibirskogo nauchnogo centra, (4), 104-108
3. Borinskaya SA (2004). Genetic diversity of peoples [Geneticheskoe raznoobrazie narodov]. Priroda, (10), 33-38.
4. Borinskaya SA, Kozlov AI, Yankovskiy NK (2009). Genes and food traditions [Geny i tradicii pitaniya]. Etnograficheskoe obozrenie, (3), 117-137.
5. Grechanina EA, Grechanina YB, Moiseenko R (2012). Association “Genetics” as the scientific and clinical basis of modern clinical genetics [Objedinenie «Genetika» – kak nauchnaya i klinicheskaya baza sovremennoy klinicheskoy genetiki] (2012). Naukoviy zhurnal MOZ Ukraїni, (1), 25-46.
6. Mikitenko DA, Timchenko OI (2009). DNA polymorphisms as the basis for the development of multifactorial diseases (data from the literature and own research) [Polimorfizmy DNK kak osnova razvitiya mul’tifaktornoy patologii (dannye literatury i sobstvennykh issledovaniy)]. Aktual’nі problemi akusherstva і gіnekologії, klіnіchnoї іmunologії ta medichnoї genetiki: Zbіrnik naukovikh prats, (17), 202-211.
7. Population divided according to nationality and knowledge of Russian language on the subjects of the Russian Federation [Naselenie po natsional’nosti i vladeniyu russkim yazykom po sub”ektam Rossiyskoy Federatsii]. Tom 4. Natsional’nyy sostav i vladenie yazykami, grazhdanstvo. Vserossiyskaya perepis’ naseleniya 2010. Available at http://www.gks.ru/free_doc/new_site/perepis2010/croc/perepis_itogi1612.htm.
8. Spiridonova MG, Stepanov VA, Maksimova NR, Puzyrev VP (2004) A population-based study of the frequency of C677T polymorphism of methylenetetrahydrofolate reductase gene in Yakutia [Populyatsionnoe issledovanie chastoty polimorfizma C677T gena metilentetragidrofolat-reduktazy v Yakutii]. Genetika, (5), 704-708.
9. Sukhovolskaya MA (2012). The homocysteine concentration in serum of healthy people with C677T mutation (Ala 222Val) in methylenetetrahydrofolate reductase gene (MTHFR) and A2756G (Asp 919 Gly) in methionine synthase (MTR) [Kontsentratsiya gomotsisteina v syvorotke krovi zdorovykh lyudey s mutatsiyami C677T (Ala 222Val) v gene metilentetragidrofolatreduktazy (MTHFR) i A2756G (Asp 919 Gly) v gene metionin-sintazy (MTR)]. Molodezh i nauka: Sbornik materialov VIII Vserossiyskoy nauchno-tekhnicheskoy konferentsii studentov, aspirantov i molodykh uchenykh, posvyashchennoy 155-letiyu so dnya rozhdeniya K.E. Tsiolkovskogo. Available at http://conf.sfu-ras.ru/sites/mn2012/section31.html.
10. Tikhonov VV (2013). Distinctive elements of the material heritage of ethnic groups, formed the historical and cultural potential of Baikal territory in the second half of XX – early XIX century [Otlichitel’nye elementy material’nogo naslediya etnosov i etnicheskikh grupp, sformirovavshikh istoriko-kul’turnyy potentsial predbaykal’ya vtoroy poloviny XX – nachala XIX veka]. Vestnik Kemerovskogo gosudarstvennogo universiteta kul’tury i iskusstv, (23), 93-100.
11. Trifonova EA, Spiridonova MG, Puzyryov VP, Stepanov VA (2009). The structure of haplotype of locus methylenetetrahydrofolate: population specificity and association with coronary atherosclerosis [Struktura gaplotipov lokusa metilentetragidrofolatreduktazy: populyatsionnaya spetsifichnost’ i assotsiatsiya s koronarnym aterosklerozom]. Meditsinskaya genetika, (1), 39-47.
12. Trifonova EA (2012). The genetic diversity and structure of linkage disequilibrium of the MTHFR gene in populations of Northern Eurasia [Geneticheskoe raznoobrazie i struktura neravnovesiya po stsepleniyu gena MTHFR v populyatsiyakh Severnoy Evrazii]. Acta Naturae, (4), 59-60.
13. Fetisova IN, Dobrolyubov AS, Lipin MA, Polyakov AV (2007). Polymorphisms genes of folate cycle and human diseases [Polimorfizm genov folatnogo obmena i bolezni cheloveka]. Vestnik novykh meditsinskikh tekhnologiy, (1), 44-48.
14. Allele frequency for polymorphic site: rs1801133. The Allele Frequency Database. Available at http://alfred.med.yale.edu/alfred/SiteTable1A_working.asp?siteuid=SI001032G.
15. Antonio-Véjar V, del Moral-Hernández O, Alarcón-Romero LC, Flores-Alfaro E, Leyva-Vázquez MA, Hernández-Sotelo D, Illades-Aguiar DB (2014). Ethnic variation of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase (MTHFR) gene in southwestern Mexico. Genetics and Molecular Research, (13), 7950-7957.
16. Binia A, Contreras AV, Canizales-Quinteros S, Alonzo VA, Tejero ME, Silva-Zolezzi I (2014). Geographical and ethnic distribution of single nucleotide polymorphisms within genes of the folate/homocysteine pathway metabolism. Genes Nutr., (9), 421.
17. Fodinger M, Horl W, Sunder-Plassmann G (1999). Molecular biology of 5,10-methylenetetrahydrofolate reductase. J. Nephrol., (13), 1-17.
18. Guéant-Rodriguez RM, Guéant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, Namour F, Chabi NW, Sanni A, Anello G, Bosco P, Romano C, Amouzou E, Arrieta HR, Sánchez BE, Romano A, Herbeth B, Guilland JC, Mutchinick OM (2006). Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am. J. Clin. Nutr., (3), 701-707.
19. Kabita S, Singh HS, Chongtham DS, Saraswathy KN (2013). MTHFR C677T polymorphism among Meiteis of Manipur (India). India. Ethnicity & Disease, (23), 379-381.
20. Li WX, Dai SX, Zheng JJ, Liu JQ, Huang JF (2005). Homocysteine metabolism gene polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) jointly elevate the risk of folate deficiency. Nutrients, (8), 6670-6687.
21. Mayor-Olea A , Callejon G, Palomares AR, Jimenez AJ, Gaitan MJ, Rodrıguez A, Ruiz M, Reyes-Engel A (2008) Human genetic selection on the MTHFR 677C/T polymorphism. BMC MedGenet, (9), 104-110.
22. Miller AL, Kelly GS. (1997). Homocesteine metabolism: nutritional modulation and impact on health and disease. Alternative Medicine Review, (4), 234-247.
23. MTHFR Gene (Protein Coding). Gene Cards Human Gene Database (2015). Available at http://www.genecards.org/cgi-bin/carddisp.pl?gene=MTHFR.
24. Ramakrishnan S, Sulochana KN, Lakshmi S, Selvi R, Angayarkanni N (2006). Biochemistry of homocystiene in health and diseases. Indian J. Biochem. Biophys., (43), 275-283.
25. Saraswathy KN, Asghar M, Samtani R, Murry B, Mondal PR, Ghosh PK, Sachdeva MP (2012). Spectrum of MTHFR gene SNPs C677T and A1298C: a study among 23 population groups of India. Mol. Biol. Rep., (4), 5025-5031.
