BASIC MECHANISMS OF PRIMARY INFERTILITY IN REPRODUCTIVE AGE WOMEN WITH HYPOTHALAMIC DYSFUNCTION IN PUBERTY
Rubrics: OBSTETRICS & GYNAECOLOGY
Authors:
1.
Amur State Medical Academy
(Department of Obstetrics and Gynecology, Head)
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
2.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Socially Significant Infections in Repro ductive Medicine, Head)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Socially Significant Infections in Reproductive Medicine, Senior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 15
to 19
Status:
Published
Received:
19.10.2017
Accepted:
08.01.2023
Published:
22.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
gipotalamicheskaya disfunkciya, ERα, PGR, NF-kV, endometriy, pervichnoe besplodie.
Abstract (English):
Gipotalamicheskaya disfunkciya yavlyaetsya naibolee rasprostranennoy patologiey pubertatnogo perioda i u 39% devochek-podrostkov soprovozhdaetsya ozhireniem. Ozhirenie yavlyaetsya odnoy iz osnovnyh prichin narusheniy reproduktivnoy funkcii u zhenschin, veduschih k snizheniyu fertil'nosti. Cel' issledovaniya – ocenit' ginekologicheskoe zdorov'e zhenschin reproduktivnogo vozrasta s gipotalamicheskoy disfunkciey v pubertatnom periode i opredelit' mehanizmy formirovaniya pervichnogo besplodiya. Provedeno prospektivnoe obsledovanie devochek-podrostkov s GD (n=170) s 2000 po 2013 gody. Iz 170 potencial'nyh uchastnikov, soglasno kriteriyam otbora, ocenka fertil'nosti provedena u 86 zhenschin reproduktivnogo vozrasta, iz nih sravnitel'naya harakteristika – u fertil'nyh zhenschin (n=46) i s pervichnym besplodiem (n=21). U zhenschin s pervichnym besplodiem s GD v pubertatnom periode, v sravnenii s fertil'nymi zhenschinami znachimo chasche vyyavlyali SPKYa (38,1%), otsutstvie zheltogo tela v odnom iz yaichnikov (71,4%), snizhenie progesterona v 2 raza v syvorotke krovi, uvelichenie ERα/PGR v 2,3 raza i aktivnosti NF-kV v 1,4 raza v endometrii v sravnenii s fertil'nymi. Uroven' ERα i PGR v endometrii snizhaetsya pri uvelichenie aktivnosti NF-kV i IMT. Ustanovlena vzaimosvyaz' aktivnosti NF-kV i IMT v obeih issleduemyh gruppah.
Gipotalamicheskaya disfunkciya yavlyaetsya naibolee rasprostranennoy patologiey pubertatnogo perioda i u 39% devochek-podrostkov soprovozhdaetsya ozhireniem. Ozhirenie yavlyaetsya odnoy iz osnovnyh prichin narusheniy reproduktivnoy funkcii u zhenschin, veduschih k snizheniyu fertil'nosti. Cel' issledovaniya – ocenit' ginekologicheskoe zdorov'e zhenschin reproduktivnogo vozrasta s gipotalamicheskoy disfunkciey v pubertatnom periode i opredelit' mehanizmy formirovaniya pervichnogo besplodiya. Provedeno prospektivnoe obsledovanie devochek-podrostkov s GD (n=170) s 2000 po 2013 gody. Iz 170 potencial'nyh uchastnikov, soglasno kriteriyam otbora, ocenka fertil'nosti provedena u 86 zhenschin reproduktivnogo vozrasta, iz nih sravnitel'naya harakteristika – u fertil'nyh zhenschin (n=46) i s pervichnym besplodiem (n=21). U zhenschin s pervichnym besplodiem s GD v pubertatnom periode, v sravnenii s fertil'nymi zhenschinami znachimo chasche vyyavlyali SPKYa (38,1%), otsutstvie zheltogo tela v odnom iz yaichnikov (71,4%), snizhenie progesterona v 2 raza v syvorotke krovi, uvelichenie ERα/PGR v 2,3 raza i aktivnosti NF-kV v 1,4 raza v endometrii v sravnenii s fertil'nymi. Uroven' ERα i PGR v endometrii snizhaetsya pri uvelichenie aktivnosti NF-kV i IMT. Ustanovlena vzaimosvyaz' aktivnosti NF-kV i IMT v obeih issleduemyh gruppah.
Keywords:
gipotalamicheskaya disfunkciya, ERα, PGR, NF-kV, endometriy, pervichnoe besplodie.
gipotalamicheskaya disfunkciya, ERα, PGR, NF-kV, endometriy, pervichnoe besplodie.
1. Spislit pervichnoe besplodie
