WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGEL AT BURNS
Rubrics: EXPERIMENTAL RESEARCH
Authors:
1.
Institute of Applied Engineering and Biotechnology
(Department of Biotechnology, Professor)
Ulan-Ude, Ulan-Ude, Russian Federation
Ulan-Ude, Ulan-Ude, Russian Federation
2.
Baikal Institute of Nature Management SB RAS
(Laboratory of Polymer Chemistry, Engineer)
Ulan-Ude, Ulan-Ude, Russian Federation
Ulan-Ude, Ulan-Ude, Russian Federation
3.
Baikal Institute of Nature Management SB RAS
(Laboratory of Polymer Chemistry, Research Officer)
Ulan-Ude, Ulan-Ude, Russian Federation
Ulan-Ude, Ulan-Ude, Russian Federation
4.
Baikal Institute of Nature Management SB RAS
(Laboratory of Polymer Chemistry, Engineer)
Ulan-Ude, Ulan-Ude, Russian Federation
Ulan-Ude, Ulan-Ude, Russian Federation
5.
East Siberian State University of Technology and Management
(Department of Biotechnology of the Institute of Applied Engineering and Biotechnology, Professor)
Ulan-Ude, Ulan-Ude, Russian Federation
Ulan-Ude, Ulan-Ude, Russian Federation
6.
Baikal Institute of Nature Management SB RAS
(Laboratory of Polymer Chemistry, Senior Research Officer)
Ulan-Ude, Ulan-Ude, Russian Federation
Ulan-Ude, Ulan-Ude, Russian Federation
Type:
Article
Pages:
from 93
to 96
Status:
Published
Received:
02.11.2017
Accepted:
10.01.2023
Published:
02.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
poligeksametilenguanidin gidrohlorid, gidrogel', ozhogi, ranozazhivlyayuschee deystvie
Abstract (English):
V poslednie desyatiletiya bylo razrabotano mnozhestvo materialov medicinskogo naznacheniya na osnove polimerov. Osoboe mesto sredi nih zanimayut gidrogeli, perspektivnye dlya primeneniya v kachestve matric- nositeley lekarstvennyh sredstv. Odnako chasche vsego geleobrazuyuschie polimery ne imeyut sobstvennoy antimikrobnoy aktivnosti, chto ogranichivaet ih ispol'zovanie tol'ko v kachestve nositelya. Poetomu dlya sozdaniya bolee effektivnogo preparata aktual'no provesti poisk takoy polimernoy osnovy, kotoraya budet sposobna vystupat' v kachestve odnogo iz deystvuyuschih komponentov preparata. K takim soedineniyam mozhno otnesti polimery guanidinovogo ryada, ispol'zuemye v sostave mnogih dezinfekcionnyh sredstv. Ranee nami byl razrabotan sposob polucheniya gidrogeley poligeksametilenguanidin gidrohlorida, zaklyuchayuschiysya v sshivanii koncevyh aminogrupp razvetvlennogo polimera formal'degidom. Issledovanie ranozazhivlyayuschego deystviya gidrogelya provodilos' v usloviyah modelirovaniya termicheskogo ozhoga na laboratornyh krysah linii Wistar. V kachestve preparata sravneniya vystupal ranozazhivlyayuschiy gel' «Levomekol'». Ustanovleno, chto gidrogel' okazyvaet vliyanie na techenie ranevogo processa, o chem svidetel'stvuyut rezul'taty vul'nografii, pokazavshie, chto sutochnoe umen'shenie ploschadi rany v naibol'shey stepeni vyrazheno u gruppy «gidrogel'», chto takzhe svidetel'stvuet o vyrazhennom reparativnom deystvii. Opredeleno, chto pri ozhoge nablyudaetsya rezkoe umen'shenie summarnogo soderzhaniya antioksidantov i narastanie kolichestva leykocitov. V dinamike na 10-y, 17-y i 24-y den' eksperimenta umen'shenie pervogo pokazatelya sostavilo 56,4 %, 33,8 % i 20,9 %, a uvelichenie vtorogo pokazatelya – sootvetstvenno na 27,7 %, 19,6 % i 6,2 % po otnosheniyu k norme. Primenenie gidrogelya, kak i levomekolya, sposobstvovalo normalizacii dannyh pokazateley. Takim obrazom, na modeli lineynoy kozhno-myshechnoy rany i termicheskogo ozhoga ustanovleno vyrazhennoe ranozazhivlyayuschee deystvie gidrogelya, o chem svidetel'stvuyut rezul'taty ranotenzometrii, vul'nografii i patomorfologicheskih issledovaniy. Otmecheno, chto gidrogel' okazyvaet vliyanie na soderzhanie v krovi antioksidantov i leykocitov, sposobstvuya normalizacii ih kolichestva.
V poslednie desyatiletiya bylo razrabotano mnozhestvo materialov medicinskogo naznacheniya na osnove polimerov. Osoboe mesto sredi nih zanimayut gidrogeli, perspektivnye dlya primeneniya v kachestve matric- nositeley lekarstvennyh sredstv. Odnako chasche vsego geleobrazuyuschie polimery ne imeyut sobstvennoy antimikrobnoy aktivnosti, chto ogranichivaet ih ispol'zovanie tol'ko v kachestve nositelya. Poetomu dlya sozdaniya bolee effektivnogo preparata aktual'no provesti poisk takoy polimernoy osnovy, kotoraya budet sposobna vystupat' v kachestve odnogo iz deystvuyuschih komponentov preparata. K takim soedineniyam mozhno otnesti polimery guanidinovogo ryada, ispol'zuemye v sostave mnogih dezinfekcionnyh sredstv. Ranee nami byl razrabotan sposob polucheniya gidrogeley poligeksametilenguanidin gidrohlorida, zaklyuchayuschiysya v sshivanii koncevyh aminogrupp razvetvlennogo polimera formal'degidom. Issledovanie ranozazhivlyayuschego deystviya gidrogelya provodilos' v usloviyah modelirovaniya termicheskogo ozhoga na laboratornyh krysah linii Wistar. V kachestve preparata sravneniya vystupal ranozazhivlyayuschiy gel' «Levomekol'». Ustanovleno, chto gidrogel' okazyvaet vliyanie na techenie ranevogo processa, o chem svidetel'stvuyut rezul'taty vul'nografii, pokazavshie, chto sutochnoe umen'shenie ploschadi rany v naibol'shey stepeni vyrazheno u gruppy «gidrogel'», chto takzhe svidetel'stvuet o vyrazhennom reparativnom deystvii. Opredeleno, chto pri ozhoge nablyudaetsya rezkoe umen'shenie summarnogo soderzhaniya antioksidantov i narastanie kolichestva leykocitov. V dinamike na 10-y, 17-y i 24-y den' eksperimenta umen'shenie pervogo pokazatelya sostavilo 56,4 %, 33,8 % i 20,9 %, a uvelichenie vtorogo pokazatelya – sootvetstvenno na 27,7 %, 19,6 % i 6,2 % po otnosheniyu k norme. Primenenie gidrogelya, kak i levomekolya, sposobstvovalo normalizacii dannyh pokazateley. Takim obrazom, na modeli lineynoy kozhno-myshechnoy rany i termicheskogo ozhoga ustanovleno vyrazhennoe ranozazhivlyayuschee deystvie gidrogelya, o chem svidetel'stvuyut rezul'taty ranotenzometrii, vul'nografii i patomorfologicheskih issledovaniy. Otmecheno, chto gidrogel' okazyvaet vliyanie na soderzhanie v krovi antioksidantov i leykocitov, sposobstvuya normalizacii ih kolichestva.
Keywords:
poligeksametilenguanidin gidrohlorid, gidrogel', ozhogi, ranozazhivlyayuschee deystvie
poligeksametilenguanidin gidrohlorid, gidrogel', ozhogi, ranozazhivlyayuschee deystvie
1. Spislit ranozazhivlyayuschee deystvie
