Ekaterinburg, Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
Anatomicheskaya blizost' licevogo i mozgovogo cherepa obuslovlivaet chastotu vozniknoveniya sochetannyh travm, kotoraya sostavlyaet 6,3‑90 % po dannym raznyh avtorov. Pri sochetannyh travmah razvivaetsya disbalans v regulyacii pro- i protivovospalitel'nyh zven'ev immunnoy sistemy, chto sposobstvuet aktivizacii patogennyh mikroorganizmov i razvitiyu vospalitel'nyh oslozhneniy. V nastoyaschem issledovanii predstavlen monitoring citokinovogo statusa u postradavshih s cerebrofacial'nymi povrezhdeniyami. V issledovanie vklyucheny 60 pacientov (56 muzhchin i 8 zhenschin) v vozraste ot 20 do 50 let s perelomami kostey licevogo skeleta v sochetanii s cherepno-mozgovymi povrezhdeniyami, za isklyucheniem ushiba golovnogo mozga tyazheloy stepeni. Pacientam provedeno issledovanie IL-6, IL-8, IL-10 i FNO syvorotki krovi po metodike IFA na 1, 3, 7 i 10 sutki posle polucheniya travmy. Znachimoe uvelichenie koncentraciy provospalitel'nyh citokinov IL-6, IL-8 (svyshe 10 pg / ml) v pervye sutki posle travmy podcherkivayut adekvatnyy otvet immunnoy sistemy na mehanicheskuyu travmu. Disbalans immunnogo otveta nablyudali v 9 % sluchayah u pacientov v ostryy period cerebrofacial'noy travmy, chto vyrazhalos' v vysokih koncentraciyah IL-10 (svyshe 31 pg / ml), FNO (bolee 6 pg / ml) i soprovozhdalos' razvitiem oslozhnennogo techeniya (zamedlennaya konsolidaciya, osteomielit).
cerebrofacial'naya travma, ostryy period, citokiny.
1. Anikeev, N. V. The analysis of work of specialized and maneuver brigade on patients assistance with the combined trauma in St. Petersburg / N. V. Anikeev //Emergency medical service. – 2007. – № 1. – P. 44‑48.
2. Belyaevsky, A. D. Tsitokina, oxidatic stress and antioxidant protection at the isolated and combined craniocereberal trauma / A. D. Belyaevsky, E. A. Lebedeva, M. E. Belousova // The General resuscitation. – 2009. – Vol. 5, № 6. – P. 36‑39.
3. Dolgikh, V. T. Functions disorder of the central nervous and immune systems in the presence of a severe mechanical trauma / V. T. Dolgikh, T. F. Sokolova, N. G. Gordiyenko // Topical issues of the combined shock-producing trauma and ambulance: edited volume. – St. Petersburg, 2002. – P. 198‑210.
4. Travm: Inflammation and immunity / N. M. Kalinin, A. E. Sosyukin, D. A. Vologzhanin, A. A. Kuzin [et al.] // Cytokines and inflammation. – 2005. – Vol. 4, № 1. – P. 28‑35.
5. Kozlov, V. K. Cytocinematherapy: a pathogenetic orientation in case of infectious diseases and clinical efficiency: a guide for doctors / V. K. Kozlov. – St. Petersburg: Alter ego, 2010. – P 148.
6. Marchenko, V. I. Use of cytokines in the treatment of injuries / V. I. Marchenko, L. A. Denisov, S. Yu. Pchelintsev // Surgery. – 2007. – № 3. – P. 65‑68.
7. The condition of administration to patients cranial and maxillofacial damages in the city of Yekaterinburg in 2000‑2009 / D. P. Samokhvalov, V. P. Zhuravlev, V. A. Petrenko, A. A. Nikolaeva // The Ural medical magazine. – 2013. – № 1. – P. 126‑130.
