employee
Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
student
Ekaterinburg, Ekaterinburg, Russian Federation
Background. Aggressive forms of periodontitis are a group of periodontal diseases characterized by rapid development, significant bone loss, few clinical manifestations, weak inflammatory and immune response, a small number of microorganisms, not proportional to the severity of destruction. According to modern ideas about the etiology of aggressive forms of periodontitis, the main reason for their development – the penetration of periodontal tissue Aggregatibacter actinomycetemcomitans. Therefore, aggressive forms of periodontitis may require adjunct antibacterial therapy. Objective ― to determine and analyze the most effective methods of antibiotic therapy in patients with aggressive forms of periodontitis. Methods. A literary review of the studies of Russian and foreign scientists on the development of approaches to improving the effectiveness of antibiotic therapy of aggressive forms of periodontitis in patients, using scientific search library databases PubMed, Medline, Cochrane, Elibrary. The main selection of materials was carried out by keywords. 37 publications were found. Results. The review describes the main methods of modern antibiotic therapy of aggressive forms of periodontitis, the main advantages of antibacterial drugs. Conclusion. In modern periodontics, there is a significant interest in the problem of antibiotic therapy of aggressive forms of periodontitis; various modes of antibiotics are studied. Most studies of this pathology are devoted to the use of moxifloxacin, azithromycin and a combination of amoxicillin and metronidazole. Additional use of antibiotics leads to better results in the treatment of aggressive forms of periodontitis.
aggressive periodontitis, periodontium, periodontal pathogens, bacterial periodontopathogens, antibacterial therapy
1. Usin, M. M., Tabares, S. M., Menso, J., de Albera, E. R., Sembaj, A. (2016). Generalized aggressive periodontitis: microbiological composition and clinical parameters in non-surgical therapy. Acta Odontol Latinoam., 29, 3, 255–261.
2. Ardila, C. M., Guzmán, I. C. (2015). Clinical Factors Influencing the Efficacy of Systemic Moxifloxacin in the Therapy of Patients With Generalized Aggressive Periodontitis: A Multilevel Analysis From a Clinical Trial. Glob J Health Sci., 8, 3, 80–88. doi: 10.5539/gjhs.v8n3p80.
3. Eds. Dmitrieva, L. A., Maksimovsky, U. M. (2015). Terapevticheskaya stomatologia [Therapeutic dentistry]. Moscow : GEOTAR-Media, 2. (In Russ.)
4. Armitage, G. C. (1999). Development of a classification system for periodontal diseases and conditions. Ann Periodontol., 4, 1, 1–6. doi: 10.1902/annals.1999.4.1.1.
5. Aimetti, M., Romano, F., Guzzi, N., Carnevale, G. (2012). Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial. J Clin Periodontol., 39, 3, 284–294. doi: 10.1111/j.1600-051X.2011.01795.x.
6. Murugesan, G., Sudha, K. M., Subaramoniam, M. K., Dutta, T., Dhanasekar, K. R. (2018). A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis. J Indian Soc Periodontol., 22, 5, 438–441. doi: 10.4103/jisp.jisp_155_18.
7. Atrushkevich, V. G., Tikhomirova, E. A., Zudina, I. V. (2018). Osobennosti mikrobiocenoza zubnogo naleta u pacientov s agressivnym i hronicheskim generalizovannym parodontitom [Peculiarities of dental plaque microbiocenosis in patients with aggressive and chronic generalized periodontitis]. Kremlevskaya medicina. Klinicheskij vestnik [Kremlin medicine. Clinical Bulletin], 2, 88–97. (In Russ.)
8. Elovikova, T. M., Uvarova, L. V. (2013). Klinicheskie proyavleniya parodontal'nogo sindroma pri ciklicheskoj nejtropenii [Case report of the patient with cyclic neutropenia and periodontal syndrome]. Problemy stomatologii [Problems of dentistry], 1, 16–19. (In Russ.)
9. Zorina, O. A., Berkutova, I. S., Basova, A. A. (2014). Antimikrobnaya ehffektivnost' sistemnogo primeneniya antibiotikov raznyh grupp v kompleksnom lechenii pacientov s hronicheskim generalizovannym parodontitom [Antimicrobial efficacy of systemic antibiotics of different groups in the complex treatment of patients with chronic periodontal disease]. Stomatologiya [Dentistry], 5, 13–18. (In Russ.)
10. Orekhova, L. Yu., Aleksandrova, A. A., Aleksandrova, L. A., Musaeva, R. S., Tolibova, G. H., Posokhova, E. V. (2014). Osobennosti stomatologicheskogo statusa u pacientov s saharnym diabetom i beremennyh zhenshchin. Mery profilaktiki stomatologicheskih zabolevanij u dannyh grupp pacientov (obzor literatury) [Clinical and cytological characteristic of a condition of the oral cavity at pregnant women with various types of a diabetes mellitus]. Parodontologiya [Periodontics], 4 (73), 18–25. (In Russ.)
11. Uvarova, L. V., Elovikova, T. M., Boronina, L. G. Sposob opredeleniya neobhodimosti naznacheniya antibakterial'noj terapii pri lechenii parodontita [A method for determining the need for appointment of antibacterial therapy in the treatment of periodontitis], patent for the invention RUS 2383018 17.11.2008.
12. Makeeva, I. M., Daurova, F. Yu., Byakova, S. F., Ippolitov, E. V., Gostev, M. S., Polikushina, A. O., Shubin, E. V. (2016). CHuvstvitel'nost' mikrobnyh associacij ehkssudata parodontal'nogo karmana i odontogennogo ochaga k antibakterial'nym preparatam [Sensitivity of microbial associations of periodontal lesions to antibacterial agents]. Stomatologiya [Dentistry], 3, 26–30. (In Russ.)
13. Chahboun, H., Arnau, M. M., Herrera, D., Sanz, M., Ennibi, O. K. (2015). Bacterial profile of aggressive periodontitis in Morocco: a cross-sectional study. BMC Oral Health., 24. doi: 10.1186/s12903-015-0006-x.
14. Wang, P. L. (2010). Roles of oral bacteria in cardiovascular diseases - from molecular mechanisms to clinical cases: Treatment of periodontal disease regarded as biofilm infection: systemic administration of azithromycin. J Pharmacol Sci., 113, 2, 126–133. doi: 10.1254/jphs.09R25FM.
15. Cifcibasi, E., Kantarci, A., Badur, S., Issever, H., Cintan, S. (2015). Impact of metronidazole and amoxicillin combination on matrix metalloproteinases-1 and tissue inhibitors of matrix metalloproteinases balance in generalized aggressive periodontitis. Eur J Dent., 9, 1, 53–59. doi: 10.4103/1305-7456.149642.
16. Krayer, J. W., Leite, R. S., Kirkwood, K. L. (2010). Non-surgical chemotherapeutic treatment strategies for the management of periodontal diseases. Dent Clin North Am., 54, 1, 13–33. doi: 10.1016/j.cden.2009.08.010.
17. Guzeldemir-Akcakanat, E., Gurgan, C. A. (2015). Systemic moxifloxacin vs amoxicillin/metronidazole adjunct to non-surgical treatment in generalized aggressive periodontitis. Med Oral Patol Oral Cir Bucal., 20, 4, 441–449. doi: 10.4317/medoral.20552.
18. Gonçalves, P. F., Huang, H., McAninley, S., Alfant, B., Harrison, P., Aukhil, I., Walker, C., Shaddox, L. M. (2013). Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis. J Periodontol., 84, 12, 1801–1808. doi: 10.1902/jop.2013.130002.
19. Prakasam, A., Elavarasu, S. S., Natarajan, R. K. (2012). Antibiotics in the management of aggressive periodontitis. J Pharm Bioallied Sci., 4, 6, 252–255. doi: 10.4103/0975-7406.100226.
20. Miller, K. A., Branco-de-Almeida, L. S., Wolf, S., Hovencamp, N., Treloar, T., Harrison, P., Aukhil, I., Gong, Y., Shaddox, L. M. (2017). Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study. J Clin Periodontol., 44, 2, 158–168. doi: 10.1111/jcpe.12640.
21. Baltacioglu, E., Aslan, M., Saraç, Ö., Saybak, A., Yuva, P. (2011). Analysis of clinical results of systemic antimicrobials combined with nonsurgical periodontal treatment for generalized aggressive periodontitis: a pilot study. J Can Dent Assoc., 77.
22. Fine, D. H., Patil, A. G., Loos, B. G. (2018). Classification and diagnosis of aggressive periodontitis. J Periodontol., 89, 103–119. doi: 10.1111/jcpe.12942.
23. Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., Flemmig, T.,F., Garcia, R., Giannobile, W. V., Graziani, F., Greenwell, H., Herrera, D., Kao, R. T., Kebschull, M., Kinane, D. F., Kirkwood, K. L., Kocher, T., Kornman, K. S., Kumar, P. S., Loos, B. G., Machtei, E., Meng, H., Mombelli, A., Needleman, I., Offenbacher, S., Seymour, G. J., Teles, R., Tonetti, M. S. (2018). Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol., 89, 173–182. doi: 10.1111/jcpe.12946.
24. Merchant, S. N., Vovk, A., Kalash, D., Hovencamp, N., Aukhil, I., Harrison, P., Zapert, E., Bidwell, J., Varnado, P., Shaddox, L. M. (2014). Localized aggressive periodontitis treatment response in primary and permanent dentitions. J Periodontol., 85, 12, 1722–1729. doi: 10.1902/jop.2014.140171.
25. Lourenço, T. G., Heller, D., do Souto, R. M., Silva-Senem, M. X., Varela, V. M., Torres, M. C., Feres-Filho, E. J., Colombo, A. P. (2015). Long-term evaluation of the antimicrobial susceptibility and microbial profile of subgingival biofilms in individuals with aggressive periodontitis. Braz J Microbiol., 46, 2, 493–500. doi: 10.1590/S1517-838246220131037.
26. Haas, A. N., Silva-Boghossian, C. M., Colombo, A. P., Albandar, J., Oppermann, R. V., Rösing, C. K., Susin, C. (2016). Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis: 12-month randomized trial. Braz Oral Res., 30, 1. doi: 10.1590/1807-3107BOR-2016.vol30.0041.
27. Ercan, E., Uzun, B. C., Ustaoglu, G. (2015). Effects of azithromycin versus metronidazole-amoxicillin combination as an adjunct to nonsurgical periodontal therapy of generalized aggressive periodontitis. Niger J Clin Pract., 18, 4, 506–510. doi: 10.4103/1119-3077.154221.
28. Skurska, A., Dolinska, E., Pietruska, M., Pietruski, J. K., Dymicka, V., Kemona, H., Arweiler, N. B., Milewsk, R., Sculean, A. (2015). Effect of nonsurgical periodontal treatment in conjunction with either systemic administration of amoxicillin and metronidazole or additional photodynamic therapy on the concentration of matrix metalloproteinases 8 and 9 in gingival crevicular fluid in patients with aggressive periodontitis. BMC Oral Health., 15. doi: 10.1186/s12903-015-0048-0.
29. Arweiler, N. B., Pietruska, M., Skurska, A., Dolińska, E., Pietruski, J. K., Bläs, M., Auschill, T. M., Sculean, A. (2013). Nonsurgical treatment of aggressive periodontitis with photodynamic therapy or systemic antibiotics. Three-month results of a randomized, prospective, controlled clinical study. Schweiz Monatsschr Zahnmed., 123, 6, 532–544.
30. Beliveau, D., Magnusson, I., Bidwell, J. A., Zaper,t E. F., Aukhil, I., Wallet, S. M., Shaddox, L. M. (2012). Benefits of early systemic antibiotics in localized aggressive periodontitis: a retrospective study. J Clin Periodontol., 39, 11, 1075–1081. doi: 10.1111/jcpe.12001.
31. Renatus, A., Herrmann, J., Schönfelder, A., Schwarzenberger, F., Jentsch, H. (2016). Clinical Efficacy of Azithromycin as an Adjunctive Therapy to Non-Surgical Periodontal Treatment of Periodontitis: A Systematic Review and Meta-Analysis. J Clin Diagn Res., 10, 7. doi: 10.7860/JCDR/2016/20176.8115.
32. Lai, P. C., Walters, J. D. (2016). Relative effectiveness of azithromycin in killing intracellular Porphyromonas gingivalis. Clin Exp Dent Res., 2, 1, 35–43. doi: 10.1002/cre2.17. doi: 10.1002/cre2.17.
33. Hirsch, R. (2010). Periodontal healing and bone regeneration in response to azithromycin. Aust Dent J., 55, 2, 193–199. doi: 10.1111/j.1834-7819.2010.01227.x.
34. Barca, E., Cifcibasi, E., Cintan, S. (2015). Adjunctive use of antibiotics in periodontal therapy. J Istanb Univ Fac Dent., 49, 3, 55–62. doi: 10.17096/jiufd.90144.
35. Elabdeen, H. R., Mustafa, M., Hasturk, H., Klepac-Ceraj, V., Ali, R. W., Paster, B. J., Van Dyke, T., Bolstad, A. I. (2015). Subgingival microbial profiles of Sudanese patients with aggressive periodontitis. J Periodontal Res., 50, 5, 674–682. doi: 10.1111/jre.12250.
36. Oettinger-Barak, O., Sela, M. N., Sprecher, H., Machtei, E. E. (2014). Clinical and microbiological characterization of localized aggressive periodontitis: a cohort study. Aust Dent J., 59, 2, 165–171. doi: 10.1111/adj.12165.
37. Lourenço, T. G., Heller, D., Silva-Boghossian, C. M., Cotton, S. L., Paster, B. J., Colombo, A. P. (2014). Microbial signature profiles of periodontally healthy and diseased patients. J Clin Periodontol., 41, 11, 1027–1036. doi: 10.1111/jcpe.12302.
