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GRNTI 76.03 Медико-биологические дисциплины
GRNTI 76.33 Гигиена и эпидемиология
OKSO 14.04.02 Ядерные физика и технологии
OKSO 31.06.2001 Клиническая медицина
OKSO 31.08.08 Радиология
OKSO 32.08.12 Эпидемиология
BBK 51 Социальная гигиена и организация здравоохранения. Гигиена. Эпидемиология
BBK 534 Общая диагностика
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
TBK 5712 Медицинская биология. Гистология
TBK 5734 Медицинская радиология и рентгенология
TBK 6212 Радиоактивные элементы и изотопы. Радиохимия
The results of numerous single-center and multicenter randomized and non-randomized studies on the treatment of patients with locally advanced rectal cancer (LARC) over a 70-year period are presented. The sequence of surgical, medicinal, radiation and chemoradiation treatment is represented. The doses and amount of radiation exposure are described, both in mono mode and with the use of various combinations of chemotherapeutic drugs in neoadjuvant and adjuvant regimens. The evolution of complex treatment that has shifted has shifted the emphasis to the use of chemoradiation therapy in the neoadjuvant period, and the introduction of new chemotherapeutic drugs and regimens have significantly increased the survival rates among patients with LARC. The approaches to the treatment of patients with LARC are not static and are constantly being improved. This literature review shows the chronological sequence and major current trends in the neoadjuvant and adjuvant components of the treatment of patients with locally advanced rectal cancer.
locally advanced rectal cancer, complex treatment, consolidation chemotherapy, induction chemotherapy, medical pathomorphosis
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