IMPROVEMENT OF APPROACHES TO TREATMENT OF CHILDREN WITH SUPERFICIAL INFANTILE HEMANGIOMAS OF THE HEAD AND NECK USING HIGH-ENERGY LASERS
Abstract and keywords
Abstract (English):
Background. Hemangiomas of the skin and mucous membranes, which belong to the group of vascular abnormalities, make up about 50% among other soft tissue tumors in children. Laser coagulation is one of the treatment methods that can provide both a radical removal of superficial hemangiomas and leaving an imperceptible trace. The goal is to increase the effectiveness of treatment of children with superficial infant hemangiomas of the head and neck by substantiating the differentiated selection of a high-energy laser. Methodology. A total of 512 children were included in the study. In accordance with the tasks of the study, the total body of material was divided into four parts: evaluation of the long-term results of the treatment of infant hemangiomas; a comparative study of the effectiveness of two laser systems in the treatment of infantile hemangiomas with varying degrees of elevation over the surrounding skin; assessment of the aesthetic efficiency of using laser technologies against the background of the modernization of the cooling method in the treatment of infantile hemangiomas of the face and neck in children; the study of the social effectiveness of the protocol for choosing a method of treatment of infantile hemangiomas of the head and neck in children. Results. The obtained statistically significant difference in changes on all scales between the two groups mathematically confirmed that the modernized approach makes it possible to obtain higher social effectiveness of the treatment, apparently due to the greater aesthetics of the remaining scars after treatment. Conclusions. A pronounced difference was found in the response of hemangiomas to various types of lasers, the combination of laser-coagulation with constant water cooling has a greater aesthetic effectiveness than the use of periodic ice applications, the social effectiveness of the approach using the protocol for choosing treatment tactics is higher than with standard approaches.

Keywords:
infant hemangiomas, laser coagulation of hemangiomas, aesthetic assessment of scars after hemangiomas, social effectiveness of hemangiomas treatment
References

1. Yilmaz, L., Kacenelenbogen, N. (2015). Cutaneous vascular anomalies in children. Rev. Med. Brux, 36, 4, 348–357.

2. Grzesik, P., Wu, J. K. (2017). Current perspectives on the optimal management of infantile hemangioma. Pediatric Health Med. Ther, 8, 107–116.

3. Darrow, D. H., Greene, A. K. (2015). Diagnosis and Management of Infantile Hemangioma : Executive Summary. Pediatrics, 136, 4, 786–791.

4. Anderson, K. R., Schoch, J. J., Lohse, C. M. et al. (2015). Increasing incidence of infantile hemangiomas (IH) over the past 35 years: Correlation with decreasing gestational age at birth and birth weight. J. Am. Acad. Dermatol, 74, 1, 120–126.

5. Smith, C. J. F., Friedlander, S. F., Guma, M. et al. (2017). Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment. Birth Defects Res, 109, 11, 809–815.

6. Tavakoli, M., Yadegari, S., Mosallaei, M. (2017). Infantile Periocular Hemangioma. J Ophthalmic Vis Res, 12, 2, 205–211.

7. Munden, A., Butschek, R., Tom, W. L. et al. (2014). Prospective study of infantile haemangiomas: incidence, clinical characteristics and association with placental anomalies. Br. J. Dermatol, 170, 4, 907–913.

8. Yang, B., Li, L., Zhang, L. X. et al. (2015). Clinical Characteristics and Treatment Options of Infantile Vascular Anomalies. Medicine (Baltimore), 94, 40, e1717.

9. Sulzberger, L. et al. (2018). Phosphorylated Forms of STAT1, STAT3 and STAT5 Are Expressed in Proliferating but Not Involuted Infantile Hemangioma. Frontiers Surgery, 5, 31.

10. Castaneda, S., Melendez-Lopez, S., Garcia, E. et al. (2016). The Role of the Pharmacist in the Treatment of Patients with Infantile Hemangioma Using Propranolol. Adv Ther, 33, 10, 1831–1839.

11. Chang, L., Gu, Y., Yu, Z. et al. (2017). When to stop propranolol for infantile hemangioma. Sci. Rep, 7, 43292. Doi: 10.1038/srep43292.Published 2017 Feb 22

12. Csoma, Z. R., Dalmády, S., Ábrahám, R., et al. (2017). Infantile haemangioma: clinical and demographic characteristics, experiences in the treatment. Orv Hetil, 158, 39, 1535–1544. Doi: 10.1556/650.2017.30838.

13. Kagami, S. 1. (2018). Oral propranolol for infantile hemangiomas beyond the proliferative phase. J Dermatol, 45, 10, 1199–1202. Doi: 10.1111/1346-8138.14581.

14. Lang, F. (2017). Hemangioma of the eyelid. Ophthalmologe, 114, 12, 117–1180. Doi: 10.1007/s00347-017-0604-x/

15. Kado, M., Shimizu, A., Matsumura, T. et al. (2017). Treatment of Infantile Hemangiomas With Propranolol in Low-Birth-Weight Infants. J Craniofac Surg, 28, 3, 789–793. Doi: 10.1097/SCS.0000000000003542.

16. Turhan, A. B., Bör, Ö., Özdemir, Z. C. (2016). Treatment with propranolol for infantile hemangiomas: single-center experience. J Cosmet Dermatol, 15, 3, 296–302. Doi: 10.1111/jocd.12220. Epub 2016 Apr 7.

17. Sharma, N., Bajpai, M., Verma, A. et al. (2015). Masterly inactivity in infantile haemangioma: Does it still hold relevance? J Paediatr Surg, 12, 3, 167–170.

18. Oliveira, J. C., Azevedo, I., Gonçalves, A. et al. (2017). Stridor is not always croup: infantile haemangioma in the airway. BMJ Case Rep, 2. Doi: 10.1136/bcr-2017-222449.

19. Achauer, B., Vander Kam, V. (1989). Capillary hemangioma (Strawberry Mark) of infancy: Comparision of Argon and Nd-YAG laser treatment. Plast. Reconstr. Surg, 84, 1, 60–69.

20. Anderson, R. R., Parrish, J. A. (1983). Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science, 220, 4596, 524–527.

21. Chinnadurai, S., Sathe, N. A., Surawicz, T. (2016). Laser treatment of infantile hemangioma: A systematic review. Lasers Surg. Med, 48, 3, 222–233. Doi: 10.1002/lsm.22455. Epub 2015 Dec 29.

22. Chinnadurai, S., Snyder, K., Sathe, N. et al. (2016). Diagnosis and Management of Infantile Hemangioma. Agency for Healthcare Research and Quality, URL : https://effectivehealthcare.ahrq.gov/topics/infantile-hemangioma/research

23. Jacob, R., Frommel, T., Maurer, J. et al. (1999). Duplex ultrasonography - controlled Nd:Yag laser therapy of vascular malformations. Ultraschall. Med, 20, 5, 191–196.

24. Nelson, J. S., Milner, T. E., Anvari, B. et al. (1995). Dynamic epidermal cooling during pulsed laser treatment of port-wine stain. A new methodology with preliminary clinical evaluation. Arch. Dermatol, 131, 695–700. Doi: 10.1001/archderm.131.6.695.

25. Kwon, S. H., Choi, J. W., Byun, S. Y. et al. (2014). Effect of early long-pulse pulsed dye laser treatment in infantile hemangiomas. Dermato.l. Surg, 40, 4, 405–411. Doi: 10.1111/dsu.12451. Epub 2014 Jan 25.

26. Hartmann, F., Lockmann, A., Grönemeyer, L. L. et al. (2017). Nd:YAG and pulsed dye laser therapy in infantile haemangiomas: a retrospective analysis of 271 treated haemangiomas in 149 children. J Eu.r Acad. Dermatol Venereol, 31, 8, 1372–1379. Doi: 10.1111/jdv.14074. Epub 2017 Jan 23.

27. Su, W., Ke, Y., Xue, J. (2014). Beneficial effects of early treatment of infantile hemangiomas with a long-pulse Alexandrite laser. Lasers Surg. Med, 46, 3, 173–179. Doi: 10.1002/lsm.22221. Epub 2014 Jan 6.

28. Vlachakis, I., Gardikis, S., Michailoudi, E. et al. (2003). Treatment of hemangiomas in children using a Nd:YAG laser in conjunction with ice cooling of the epidermis: techniques and results. BMC Pediatr, 3, 2.

29. Choi, J. S., Bae, Y. C., Nam, S. B. et al. (2018). Evaluation of the donor site after the median forehead flap. Archives of Plastic Surgery, 45, 3, 259–265. URL : http://doi.org/10.5999/aps.2017.01277.

30. Mossaad, A., Kotb, A., Abdelrahaman, M. et al. (2018). Post-surgical repair of cleft scar using fractional CO2 laser. Open Access Macedonian Journal of Medical Sciences, 6, 7, 1231–1234.

31. Landthaler, M., Hohenleuther, U., El-Raheem, T. A. (1995). Laser therapy of childhood hemangiomas. Br. J. Dermatol, 133, 275–281.


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