For the purpose of an assessment of influence of chemotherapy by САР scheme on aerobiotic cytotoxicity in neutrophils of peripheral blood of 43 primary patients with cancer ovarian at the III-IV clinical stages on FIGO the level myeloperoxidase and activity in the spontaneous NST-test was determined. Cages were allocated from a blue blood on a double gradient fikoll-urografin (ρ = 1,117 and 1,077 g/ml). Comparison of the quantitative variables corresponding to normal distribution was carried out by means of Student´s test. Results are presented in the form of average cytochemical coefficient. The patients passable inspection and treatment in Ulyanovsk in regional clinical oncological clinic, received a polychemotherapy course, according to САР scheme. Indicators of aerobiotic cytotoxicity, absolute and relative quantity of neutrophils of peripheral blood were defined till 3 days after introduction of chemotherapeutic agent. As a result of the conducted researches it is established that in the patients at the IV clinical stage on FIGO the increased to polychemotherapy absolute and relative quantity of neutrophils decreases and practically the indicators characterizing aerobiotic cytotoxicity don´t change. In the patients at the III stage of a cancer ovarian on FIGO increase of absolute and relative quantity of neutrophils at simultaneous decrease in indicators myeloperoxidase and NST-test takes place. The obtained data testify to need of individual monitoring of reactivity of neutrophils at suffering from cancer ovaries at the III-rd stage of a disease after the first course of polychemotherapy according to CAP scheme.
cancer ovarian, neutrophils, polychemotherapy.
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