A comparative evaluation of detoxification properties of a powder of brown peat moss’s turf, activated charcoal and polisorb has been studied on a model of chronic endotoxicosis, simulated by the administration of tetrachloromethane and lipopolysaccharide S. thyphi to the experimental animals. The effectiveness of the investigated objects has been evaluated by their effect on serum biochemical parameters and histology of liver and kidney. The administration of tetrachloromethane and lipopolysaccharide to the rats in the chronic experiment has shown statistically significant increase of aspartataminotransferase, alaninaminotransferase and malondialdehyde, and have been decreased significantly protein and urea in serum. The administration of powder of brown peat moss’s turf to the animals with experimental chronic endotoxicosis has limited the toxicity of tetrachloromethane and lipopolysaccharide. This has been resulted in lower activities of aspartataminotransferase and alaninaminotransferase, and level of malondialdehyde. But levels of protein and urea have been increased in serum, that indicating of a partial normalization functions of liver. Thus, the course administration of investigated sorbents in steady of experimental chronic endotoxicosis is accompanied by a significant decrease of endotoxic reaction associated with disruption of the structure and functions of the cells of liver. The detoxification activity of the powder of brown peat moss’s turf doesn’t yield to the effects of polisorb and activated charcoal.
sphagnum mosses, powder of brown peat moss, enterosorbent.
1. Adsorbtsionnaya aktivnost´ syr´ya vodno-bolotnykh rasteniy Zapadnoy Sibiri / Kelus N.V., Babeshina L.G., Dmitruk S.E. [i dr.]. Byulleten´ sibirskoy meditsiny. 2009. № 4. S. 37-41.
2. Krivolapov Yu.A., Leenman E.E. Morfologicheskaya diagnostika limfom. SPb.: «Izdatel´sko-poligraficheskaya kompaniya «KOSTA», 2006. 208 s.
3. Novochadov V.V., Pisarev V.B. Endotoksikoz: Modelirovanie i organopatologiya: monografiya. Volgograd: Izd-vo VolGMU, 2005. 240 s.
4. Sarkisov D.S. Perov D.S. Mikroskopicheskaya tekhnika. M.: Meditsina, 1996. 544 s.
5. Kelus V.S., Chuchalin V.S., Ivanov V.V., Dzyuman A.N., Kaydash O.A., Yartsev K.S. Terapevticheskaya effektivnost´ enterosorbentov na modeli ostrogo endotoksikoza. Vestnik novykh meditsinskikh tekhnologiy. 2013. T. 20. № 3. S. 133–139.
6. Turishchev S.P Ozdorovlenie i fitoterapiya. Vrach: Ezhemesyachnyy nauchno-prakticheskiy i publitsisticheskiy zhurnal Moskovskaya meditsinskaya akademiya im. I.M. Sechenova. 2004. № 10. S. 62–64.
7. Chuchalin V.S. Farmakologicheskie i tekhnologicheskie aspekty razrabotki novykh gepatoprotektivnykh preparatov prirodnogo proiskhozhdeniya: dis. … d-ra farm. nauk. Tomsk, 2003. 317 s.
8. Uchaykin V.F., Novokshonov A.A., Sokolova N.V., Berezhkov T.V. Enterosorbtsiya − rol´ enterosorbentov v kompleksnoy terapii ostroy i khronicheskoy gastroenterologicheskoy patologii: posobie dlya vrachey. Moskva, 2008. 24 s.
9. Enterosorbtsiya effektivnyy metod etiopatogeneticheskoy terapii ostrykh kishechnykh infektsiy / Uchaykin V.F., Novokshonov A.A., Sokolova N.V. [i dr.]. Detskie infektsii. 2005. № 3. S. 39–43.
10. Chronic treatment with the antidepressant tianeptine attenuates lipopolysaccharide-induced Fos expression in the rat paraventricular nucleus and HPA axis activation / Casta-non N., Konsman J.P. [et al.]. Psychoneuroendocrinology. 2003. Vol. 28. № l. P. 19–34.
11. Yagi K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem. Med. 1976. Vol. 12. № 2. P. 212–216.
12. Khadartsev A.A., Yashin A.A., Es´kov V.M., Agarkov N.M., Kobrinskiy B.A., Frolov M.V., Chukhraev A.M., Gondarev S.N., Khromushin V.A., Kamenev L.I., Valentinov B.G., Agarkova D.I. Informatsionnye tekhnologii v meditsine. Monografiya. Tula: TulGU, 2006. 272 s.
