The review summarizes the research activity of scientists of the Tula region aimed at creation and development of new biomedical technologies. Areas of research presented in the monographs, patents, discoveries, articles have been identified, examined and implemented in experimental, clinical practice. The research areas are the following: nano-technology, nuclear medicine, technologies of mathematical assessment of complex systems parameters, thesiography of blood and biological fluids, the use technologies of laser radiation in the diagnosis and correction of functional changes, technology of matrix uncooled thermal imaging systems, the spectrofluorimetry autof-luorescence, mechanical simulators, cellular technologies, control technologies of functional systems of the body, biomedical technologies in sport.
nano-technology, nuclear medicine, thesiography of blood and biological fluids, laser radiation, spectrofluorimetry, autofluorescence, mechanical simulators, cellular technologies, control technologies of functional systems of the body, biomedical technologies in sport.
Тульская научная медико-биологическая школа формировалась в течение 40 лет. При этом определи-лись два стратегических направления. Первое – создание теоретической основы биомедицины, экологии и безопасности жизнедеятельности человека, объясняющие механизмы взаимодействия физических полей с живым веществом, преимущественно на клеточном, молекулярно-генетическом уровне. Второе – создание теории управления деятельностью функциональных систем организма человека для осуществления управ-ляющих воздействий на здоровый или больной организм с целью оптимизации его жизнедеятельности.
1. Bolyusy Khuato (rezul´taty i perspektivy primeneniya): Monografiya / Pod red. B.G. Valentinova, A.A. Khadartseva. Tula: Izd-vo TulGU – Belgorod: ZAO «Belgorodskaya oblastnaya tipografiya», 2012. 430 s.
2. Borisova O.N., Khadartsev A.A. Diagnostika effektivnosti nemedikamentoznykh metodov lecheniya v klinike vnutrennikh bolezney; pod red Khadartseva. Tula, 2004.
3. Venevtseva Yu.L., Mel´nikov A.Kh., Khadartsev A.A. Tsvetovoe predpochtenie: effektivnost´ deyatel´-nosti, napryazhennost´ adaptatsii i prognozirovanie zdorov´ya. Vestnik novykh meditsinskikh tekhnologiy. 1998. T. 5. № 2. S. 31–32.
4. Volkov E.P., Khadartsev A.A., Biryuk A.V., Dobrynin L.D. Ustroystvo dlya izmereniya parametrov dykhaniya / A.s. № 1817301, zayavka № 4472694/14 ot 04.07.88. 1988.
5. Vosstanovitel´naya meditsina. Tom 5 / Pod red. V.D. Bitsoeva, S.N. Gontareva, A.A. Khadartseva. Tu-la: Izd-vo TulGU – Belgorod: ZAO «Belgorodskaya oblastnaya tipografiya», 2012. 228 s.
6. Gryazev M.V., Khadartsev A.A., Khrupachev A.G., Tulyakov S.P. Metodika integral´noy otsenki znaniy abiturientov. Vysshee obrazovanie v Rossii. 2010. № 6. S. 28–32.
7. Dudin N.S., Rusak S.N., Khadartsev A.A., Khadartseva K.A. Novye podkhody v teorii ustoychivosti bio-sistem – al´ternativa teorii Lyapunova. Vestnik novykh meditsinskikh tekhnologiy. 2011. № 3. S. 336.
8. Es´kov V.M., Burov I.V., Filatova O.E., Khadartsev A.A. Osnovy bioinformatsionnogo analiza di-namiki mikrokhaoticheskogo povedeniya biosistem. Vestnik novykh meditsinskikh tekhnologiy. 2012. № 1. S. 15–18.
9. Es´kov V.M., Zilov V.G., Khadartsev A.A. Novye podkhody v teoreticheskoy biologii i meditsine na baze teorii khaosa i sinergetiki. Sistemnyy analiz i upravlenie v biomeditsinskikh sistemakh. 2006. T. 5. № 3. S. 617–623.
10. Es´kov V.M., Filatova O.E., Fudin N.A., Khadartsev A.A. Novye metody izucheniya intervalov ustoy-chivosti biologicheskikh dinamicheskikh sistem v ramkakh kompartmentno-klasternogo podkhoda. Vestnik no-vykh meditsinskikh tekhnologiy. 2004. № 3. S. 5–6.
11. Es´kov V.M., Khadartsev A.A., Es´kov V.V., Gavrilenko T.V., Filatov M.A. Complexity – osobyy tip biomedtsinskikh i sotsial´nykh sistem. Vestnik novykh meditsinskikh tekhnologiy. 2013. № 1. S. 17–22.
12. Es´kov V.M., Khadartsev A.A., Kamenev L.I. Novye bioinformatsionnye podkhody v razvitii medi-tsiny s pozitsiy tret´ey paradigmy (personifitsirovannaya meditsina – realizatsiya zakonov tret´ey para-digmy v meditsine). Vestnik novykh meditsinskikh tekhnologiy. 2012. № 3. S. 25–28.
13. Es´kov V.M., Khadartsev A.A., Kozlova V.V., Filatova O.E. Ispol´zovanie statisticheskikh metodov i metodov mnogomernykh fazovykh prostranstv pri otsenke khaoticheskoy dinamiki parametrov nervno-myshechnoy sistemy cheloveka v usloviyakh akusticheskikh vozdeystviy. Vestnik novykh meditsinskikh tekhnolo-giy. 2014. № 2. S. 6–10.
14. Es´kov V.M., Khadartsev A.A., Filatova O.E., Khadartseva K.A. Okolosutochnye ritmy pokazateley kar-dio-respiratornoy sistemy i biologicheskogo vozrasta cheloveka. Terapevt. 2012. № 8. S. 36–44.
15. Ivanov D.V., Lennikov R.V., Morozov V.N., Savin E.I., Subbotina T.I., Khadartsev A.A., Yashin A.A. Effekt donor-aktseptornogo perenosa prokhodyashchim elektromagnitnym izlucheniem sano- i patogennykh kha-rakteristik bioob´´ekta i sozdanie novykh meditsinskikh tekhnologiy. Vestnik novykh meditsinskikh tekhno-logiy. 2010. № 2. S. 10–16.
16. Ivanov D.V., Khadartsev A.A. Kletochnye tekhnologii v vosstanovitel´noy meditsine: Monografiya / Pod red. A.N. Lishchuka. Tula: Tul´skiy poligrafist, 2011. 180 s.
17. Ivanov D.V., Khadartsev A.A., Khadartsev V.A., Korzhuk N.L. Komplekt dlya vydeleniya iz vlagalishchnogo tampona menstrual´noy krovi i ee khraneniya. Patent na izobretenie № 2413486.– Byul. № 7 ot 10.03.2011 g.
18. Ivanov D.V., Khadartsev A.A., Khadartsev V.A., Korzhuk N.L. Komplekt dlya vydeleniya vlagalishchnogo tampona menstrual´noy krovi i ee khranenie. Patent na poleznuyu model´ № 93268.– Byul. 12 ot 27.04.2010 g.
19. Izbrannye tekhnologii diagnostiki: Monografiya / V.M. Es´kov [i dr.]; pod red. A.A. Khadartseva, V.G. Zilova, N.A. Fudina. Tula: OOO RIF «INFRA», 2008. 296 s.
20. Kidalov V.N., Khadartsev A.A. Teziografiya krovi i biologicheskikh zhidkostey / Pod red. A.A. Khadar-tseva. Tula: Tul´skiy poligrafist, 2009. 244 s.
21. Kidalov V.N., Khadartsev A.A., Bagautdinov Sh.M., Chechetkin A.V. Postoyanstvo nepostoyannogo v te-ziogrammakh preparatov krovi (k standartizatsii issledovaniy kristallizatsii biologicheskikh zhidkostey). Vestnik novykh meditsinskikh tekhnologiy. 2008. № 4. S. 7–13.
22. Kidalov V.N., Khadartsev A.A., Syasin N.I., Yakushina G.N., Krayukhin A.V. Autofluorestsentsiya nativ-nykh tkaney i kletok krovi i ee znachenie dlya meditsinskoy praktiki: Monografiya. Tula – Sankt Peterburg, 2005. 108 s.
23. Kidalov V.N., Khadartsev A.A., Yakushina G.N., Yashin A.A. Fraktal´nost´ i vurfy krovi v otsenkakh re-aktsii organizma na ekstremal´nye vozdeystviya. Vestnik novykh meditsinskikh tekhnologiy. 2004. № 3. S. 20–23.
24. Leonov B.I., Khadartsev A.A., Varfolomeev M.A., Fudin N.A., Khadartsev V.A., Mityushkina O.A. Per-spektivy primeneniya nemedikamentoznykh tekhnologiy v sporte. Vestnik novykh meditsinskikh tekhnologiy (elektronnoe izdanie). 2012. № 1. URL: http://medtsu.tula.ru/VNMT/Bulletin/E2012-1/4115.pdf
25. Melay A.M., Chuchalin A.G., Khadartsev A.A., Melay A.A. Ustroystvo dlya vvedeniya lekarstvennykh po-roshkov. Patent № 2014097.– Byul. № 11 ot 15.06.94. 1994.
26. Melay E.A., Khadartsev A.A., Melay A.A., Ptachek A.O., Chibisov K.G., Melay A.M. Ustroystvo dlya dy-khatel´nykh uprazhneniy. Patent № 2164805.– Byul. № 10 ot 10.04.2001. 2001.
27. Melay E.A., Khadartsev A.A., Melay A.A., Fedorov S.Yu., Chibisov K.G., Melay A.M. Ingalyator.. Pa-tent № 2143283. Byul. № 36 ot 27.12.99. 1999.
28. Morozov V.N., Khadartsev A.A., Vetrova Yu.V., Gus´kova O.V. Nespetsificheskie (sintoksicheskie i ka-tatoksicheskie) mekhanizmy adaptatsii k dlitel´nomu vozdeystviyu kholodovogo razdrazhitelya. Vestnik no-vykh meditsinskikh tekhnologiy. 2000. T. 7. № 3–4. S. 100–105.
29. Oleynikova M.M., Mikhaylova A.A., Zilov V.G. [i dr.] Psikhosomaticheskie i somatoformnye ras-stroystva v reabilitologii (diagnostika i korrektsiya). Pod red. A.A. Khadartseva. Tula, 2003.
30. Profilaktika i vyyavlenie varikoznoy bolezni ven nizhnikh konechnostey u sportsmenov: Monogra-fiya / Pod red. E.V. Naumenko, A.A. Khadartseva – Tula: OOO «Tul´skiy poligrafist», 2013. 158 s.
31. Ryazanova E.A., Khadartsev A.A. Lazeroforez gialuronovoy kisloty v profilaktike i vosstanovitel´-noy terapii narusheniy funktsiy kozhi. Fundamental´nye issledovaniya. 2006. № 9. S. 110.
32. Sistemnyy analiz, upravlenie i obrabotka informatsii v biologii i meditsine. Chast´ IX. Bioin-formatika v izuchenii fiziologicheskikh funktsiy zhiteley Yugry. Samara, 2010. 196 s.
33. Sistemnyy analiz, upravlenie i obrabotka informatsii v biologii i meditsine. Chast´ VIII. Obshchaya teoriya sistem v klinicheskoy kibernetike / M.Ya. Braginskiy, I.N. Vechkanov, A.A. Glushchuk [i dr.]; Pod red. V.M. Es´kova, A.A. Khadartseva. Samara: OOO «Ofort», 2009. 198 s.
34. Sistemnyy analiz, upravlenie i obrabotka informatsii v biologii i meditsine. Chast´ VII. Sinerge-ticheskiy kompartmentno-klasternyy analiz i sintez dinamiki povedeniya vektora sostoyaniya organizma cheloveka na severe RF v usloviyakh sanogeneza i patogeneza / V.I. Adaykin, F.I. Ausheva, Yu.G. Burykin [i dr.]; Pod red. V.M. Es´kova i A.A. Khadartseva. Samara: OOO «Ofort», 2008. 159 s.
35. Titkov S.I., Protopopov A.A., Subbotina T.I., Khadartsev A.A., Yashin A.A. Sposob perenosa energo-informatsionnykh kharakteristik etalonnogo bioob´´ekta na intaktnyy bioob´´ekt. Patent № 2183483.– Byul. 17 ot 20.06.02. 2002.
36. Fiziologicheskiy pauerlifting: Monografiya / Pod red. V.A. Taymazova, A.A. Khadartseva. Tula: OOO «Tul´skiy poligrafist», 2013. 120 s.
37. Filatova O.E., Khadartsev A.A., Es´kov V.V., Filatova D.Yu. Neopredelennost´ i neprognoziruemost´ – bazovye svoystva sistem v biomeditsine. Complexity. Mind. Postnonclassic. 2013. № 1. S. 67–82.
38. Khadartsev A.A. Biofizikokhimicheskie protsessy v upravlenii biologicheskimi sistemami. Vestnik novykh meditsinskikh tekhnologiy. 1999. N2. S.34–37.
39. Khadartsev A.A. Izbrannye tekhnologii ne medikamentoznogo vozdeystviya v reabilitatsionno-vosstanovitel´noy i sportivnoy meditsine / Pod red. N.A. Fudina. Tula: OOO RIF «Infra», 2009. 398 s.
40. Khadartsev A.A. Ne medikamentoznye tekhnologii (refleksoterapiya, girudoterapiya, fitoterapiya, fi-zioterapiya). Germaniya: Palmarium Academic Publishing, 2012. 512 c.
41. Khadartsev A.A. Novye meditsinskie tekhnologii na osnove vzaimodeystviya fizicheskikh poley i izlu-cheniy s biologicheskimi ob´´ektami. Vestnik novykh meditsinskikh tekhnologiy. 1999. №1. S. 7.
42. Khadartsev A.A. Razrabotka sposobov kul´tivirovaniya i napravlennoy kardiomiotsitarnoy diffe-rentsirovki endometrial´nykh stvolovykh kletok s tsel´yu ikh primeneniya v zamestitel´noy terapii. Otchet o NIR № 02.512.12.2058 ot 22.05.2009 (Ministerstvo obrazovaniya i nauki RF)
43. Khadartsev A.A. Upravlyaemaya differentsiatsiya stvolovykh kletok (embrional´nykh i gemopoeticheskikh) elektoromagnitnym izlucheniem kraynevysokochastotnogo diapazona. otchet o NIR № 02.512.11.2137 ot 25.06.2007 (Ministerstvo obrazovaniya i nauki RF)
44. Khadartsev A.A., Korzhuk N.L., Fudin N.A., Khadartsev V.A., Es´kov V.M., Shcherbakov D.V. Mekhanotre-nazhery dykhatel´noy muskulatury v podgotovke sportsmena. Fizioterapevt. 2013. № 2. S. 30–39.
45. Khadartsev A.A., Subbotina T.I., Ivanov D.V., Gontarev S.N. Mediko-biologicheskie aspekty kletochnykh tekhnologiy: Monografiya / Pod red. A.A. Khadartseva – Tula: Izd-vo TulGU – Belgorod: ZAO «Belgorodskaya oblastnaya tipografiya», 2013. 288 s.
46. Khadartsev A.A., Tuktamyshev I.I., Tuktamyshev I.Sh. Shungity v meditsinskikh tekhnologiyakh. Vestnik novykh meditsinskikh tekhnologiy. 2002. № 2. S. 83.
47. Khadartsev A.A., Tutel´yan V.A., Zilov V.G., Es´kov V.M., Kidalov V.N., Kartashova N.M., Naumova E.M. Teoriya i praktika vosstanovitel´noy meditsiny: Monografiya / Pod red. V.A. Tutel´yana. Tula: Tul´skiy poligrafist – Moskva: Rossiyskaya akademiya meditsinskikh nauk, 2004. T. I. 248 s.
48. Khadartsev A.A., Fudin N.A., Orlov V.A. Mediko-biologicheskie tekhnologii v sporte. Moskva: Izd-vo «Izvestiya», 2011. 460 s.
49. Khadartsev A.A., Khoruzhaya V.A., Danilyak I.G. Primenenie lazernogo izlucheniya v kompleksnoy terapii bol´nykh bronkhial´noy astmoy. Klinicheskaya meditsina. 1988. № 6. S. 53.
50. Khadartsev A.A., Yashin A.A., Yashin S.A., Subbotina T.I., Khasaya D.A., Lennikov R.V., Tereshkina O.V. Sposob produtsirovaniya stvolovykh kletok. Patent na izobretenie № 2405599.– Byul. № 34 ot 10.12.2010 g.
51. Adaptogeny v meditsinskikh i biologicheskikh sistemakh (Teoriya i praktika vosstanovitel´noy medi-tsiny. Tom III.): Monografiya / Khadartsev A.A.[i dr.] / [nauch. red. A.A. Khadartseva i V.M. Es´kova]. Tula – Moskva: Rossiyskaya akademiya meditsinskikh nauk, 2005. 220 s.
52. Khadartsev V.A., Varfolomeev M.A., Troitskiy M.S., Khadartsev A.A. Sposob trenirovki dykhatel´noy muskulatury v sisteme reabilitatsii. Terapevt. 2011. № 8. S. 38–42.
53. Khrenov P.A., Khadartsev A.A., Savin E.I., Subbotina T.I., Chestnova T.V., Buzulukov Yu.P., Antsiferova A.N. Eksperimental´noe issledovanie antibakterial´noy aktivnosti nanochastits serebra na modeli peritonita i meningoentsefalita in vivo. Vestnik novykh meditsinskikh tekhnologiy (elektronnyy zhurnal). 2014. №1. URL: http://medtsu.tula.ru/VNMT/Bulletin/E2014-1/4793.pdf
54. Khromushin V.A., Khadartsev A.A., Buchel´ V.F., Khromushin O.V. Algoritmy i analiz meditsinskikh dannykh: uchebnoe posobie. Tula: Tul´skiy poligrafist, 2010. 123 s.
55. Khromushin V.A., Khadartsev A.A., Khromushin O.V., Chestnova T.V. Obzor analiticheskikh rabot s is-pol´zovaniem algebraicheskoy modeli konstruktivnoy logiki. Vestnik novykh meditsinskikh tekhnologiy (elektronnyy zhurnal). 2011. № 1. URL: http://medtsu.tula.ru/VNMT/Bulletin/E2011-1/LitObz.pdf
56. Khrupachev A.G., Khadartsev A.A., Kamenev L.I., Panova I.V., Sedova O.A. Metodologicheskaya kontseptsiya professional´nogo riska i ego kolichestvennaya otsenka. Natsional´nye interesy: prioritety i bezo-pasnost´. 2010. № 35. S. 69–80.
57. Chuchalin A.G., Fedorov S.Yu., Nikanorov B.A., Khadartsev A. A., Evteev K.P. Sposob ingalyatsii. Pa-tent № 2104050, Byul. № 4 ot 10.02.98. 1998.
58. Subbotina T.I., Tereshkina O.V., Khadartsev A.A., Yashin A.A. Effect Of Low-Intensity Extremely High Frequency Radiation On Reproductive Function In Wistar Rats.. Bulletin of Experimental Biology and Medicine. 2006. T. 142. № 2. S. 189–190.
