employee
N.N. Semenov Institute of Chemical Physics ( Senior Researcher)
employee
Russian Federation
employee
employee
Russian Federation
GRNTI 76.03 Медико-биологические дисциплины
GRNTI 76.33 Гигиена и эпидемиология
OKSO 14.04.02 Ядерные физика и технологии
OKSO 31.06.2001 Клиническая медицина
OKSO 31.08.08 Радиология
OKSO 32.08.12 Эпидемиология
BBK 51 Социальная гигиена и организация здравоохранения. Гигиена. Эпидемиология
BBK 534 Общая диагностика
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
TBK 5712 Медицинская биология. Гистология
TBK 5734 Медицинская радиология и рентгенология
TBK 6212 Радиоактивные элементы и изотопы. Радиохимия
The review represents comparative data on the biological effects of inorganic (HTO) and organic (OBT) compounds of tritium at the molecular, cytogenetic and system levels. The data of the relative biological effectiveness (RBE) of OBT and HTO depending on their distribution in the cells and tissues of the body are presented. Experimental studies show that the calculation of the RBE of tritium compounds at different levels of organization leads to contradictory data. Such observation is associated with the interaction both of HTO and OBT with critical biomolecules in the cells as well as the proliferative activity of different cells and tissues. The experiments revealed that the effectiveness of OBT is much higher than the HTO which is associated with their rapid inclusion in the critical biomolecules such as proteins and DNA with the further formation of a significant biological effect. Based on the recently obtained data in different laboratories on the effect of tritium compounds at the molecular and cellular levels, it is concluded that a new approach for HTO and OBT risk assessment is necessary.
tritium, organic compounds of the tritium, tritium oxide, HTO, OBT, RBE, DNA double-strand breaks, γН2АХ, 3H-thymidine, tritiated water, risk assessment
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