graduate student
employee
employee
GRNTI 76.03 Медико-биологические дисциплины
GRNTI 76.33 Гигиена и эпидемиология
OKSO 14.04.02 Ядерные физика и технологии
OKSO 31.06.2001 Клиническая медицина
OKSO 31.08.08 Радиология
OKSO 32.08.12 Эпидемиология
BBK 51 Социальная гигиена и организация здравоохранения. Гигиена. Эпидемиология
BBK 534 Общая диагностика
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
TBK 5712 Медицинская биология. Гистология
TBK 5734 Медицинская радиология и рентгенология
TBK 6212 Радиоактивные элементы и изотопы. Радиохимия
Actuality: In the Belarus, the primary incidence of thyroid pathology is in the 2d rank among endocrine diseases after diabetes. Studying the trends in the primary incidence of autoimmune thyroiditis (AIT) in the Belarus is important for improving organizational decisions and further improving the quality of medical care for the population. Purpose: Is to conduct a comparative analysis of the incidence of AIT in the population and in the affected population based on an epidemiological study in the Belarus, taking into account the radiation and organizational components in the formation of pathology. Material and methods: The data of the republican statistical reports and the data of the Chernobyl Register from 1997 to 2017 were analyzed. Standard methods of descriptive epidemiology were used in the work. Results: According to Chernobyl Registry, during the observation period (1997–2017), the primary incidence of AIT decreased by 1.4 times (1997 – 135.1 ± 15.77 0/0000; 2017 – 98.4 ± 7.55 0/0000). The incidence was statistically significantly higher in women than men (ratios ranged from 2.39: 1 in 2004 to 4.0: 1 in 2000). Moreover, the incidence according to Chernobyl Registry was higher than in the adult population, but in children where was no difference with population data. This indicates a high-quality clinical examination of the children’s population. Two organizational and medical approaches have been formed in the republic. The first approach (Grodno, Brest, Minsk regions and Minsk) is characterized by periods of moderate growth, decline, and growth again. In the second approach (Vitebsk, Mogilev and Gomel regions), there are two periods when the increase in incidence sharply changes to decrease before the end of the study period. An analysis of the odds ratio allowed us to conclude that insignificant effect of radioactive iodine on the incidence of AIT in children at the time of the accident and its absence in the adult population. Conclusion: The study confirms the importance of the organizational component in the early diagnosis of AIT.
autoimmune thyroiditis, primary incidence, organizational medical approach, radiation factor, Belarus
1. Biondi B. The Normal TSH Reference Range: What Has Changed in the Last Decade? J Clin Endocrinol Metab. 2013;98(9):3584-7.
2. Nexo MA, Watt T, Pedersen J, Bonnema SJ, Hegedüs L, Rasmussen AK, et al. Increased Risk of Long-Term Sickness Absence, Lower Rate of Return to Work, and Higher Risk of Unemployment and Disability Pensioning for Thyroid Patients: A Danish Register-Based Cohort Study. J Clin Endocrinol Metab. 2014;99:3184-92.
3. Noureldine S. Association of Hashimoto’s thyroiditis and thyroid cancer. Curr Opin Oncol. 2015;27(1):21-5.
4. Pedersen CB. The Danish Civil Registration System. Scand J Public Health. 2011;39(7):22-25.
5. Pedersen J, Bjorner JB, Burr H, Christensen KB. Transitions between sickness absence, work, unemployment, and disability in Denmark 2004-2008. Scand J Work Environ Health. 2012;38(6):516-26.
6. Torimoto K, Okada Y, Nakayamada S, Kubo S, Tanaka Y. Anti-PD-1 antibody therapy induces Hashimoto’s disease with an increase in peripheral blood follicular helper T cells. Thyroid. — 2017;27:1335-6.
7. Bronnikov VI, Golyreva TP, Tereshchenko IV. The influence of anthropogenic pollution on the structure of the thyroid gland in Perm residents. Arch. pathology. 2005(6):18-21. (in Russ.).
8. Karlovich N.V, Mohort T.V, Vorontsova T.V. The prevalence and nature of autoimmune thyroid pathology in young people with type 1 diabetes mellitus. Probl. endocrinology. (in Russ.).
9. [Tkach NV, Paramonova NS, Kareva EG. The dynamics of the incidence of autoimmune thyroiditis in children and adolescents of the Grodno region. Journal of State Medical University. (in Russ.).
10. Hu S, Rayman MP. Multiple Nutritional Factors and the Risk of Hashimoto’s Thyroiditis. Thyroid. 2017;27(5):597-610.
11. Rugger RM, Trimarchi F, Guiffrida G, et al. Autoimmune comorbidities in Hashimoto’s thyroiditis: different patterns of association in adulthood and childhood/adolescence. Eur J Endocrinology. 2017;176(2):133-41.
12. Koenigsberg JE, Hook YuE. Irradiation of the thyroid gland of residents of Belarus due to the Chernobyl accident: doses and effects. Gomel: RNIUP “Institute of Radiology”, 2004. 121 p. (in Russ.).
13. On the procedure for organizing a dispensary examination of citizens affected by the Chernobyl disaster, other radiation accidents and invalidating certain decisions of the Ministry of Health of the Republic of Belarus and a structural element of a regulatory legal act: resolution of the Ministry of Health of the Republic of Belarus, March 16, 2010, No. 28 [cited 2020 Feb 21]. Available from: http://pravo.levonevsky.org/bazaby11/republic07/text084.htm (in Russ.).
14. On approval of the instructions on the procedure for the medical examination: Decree of the Ministry of Health of the Republic of Belarus, 08.08.2016, No. 96. [cited 2020 Feb 21]. Available from: http://minzdrav.gov.by/upload/dispanserizatsiya/instruktsiya/000127_245033_postan96.pdf (in Russ.)].
15. Moiseev PI, Veyalkin IV, Demidchik YuE. Epidemiology of malignant neoplasms: principles and methods. Guide to oncology: a textbook. Ed OG Sukonko. Minsk, 2015:51-82. (in Russ.)].
16. Breslow NE, Day NE. Statistical methods in cancer research. The design and analysis of cohort studies. Lyon: IARC, 1987;2. 404 p.
17. Danilova LI. Thyroid Diseases and Associated Diseases. Minsk-Nagasaki. 2005. 470 p. (in Russ.).
