Samara, Russian Federation
employee
Samara, Samara, Russian Federation
Samara, Samara, Russian Federation
Samara, Russian Federation
Samara, Russian Federation
Subject. Lichen planus is a chronic inflammatory disease of the skin and mucous membranes, less commonly affecting nails and hair, the typical elements of which are papules. In the structure of diseases localized on the oral mucosa, chronic lichen planus is up to 35―40 %. A number of authors indicate the nature of the development of lichen planus in the oral cavity caused by herpes, in particular type 4 herpes virus (Epstein―Barr). The goal is to increase the efficiency of diagnosis and treatment of patients with lichen planus associated with the Epstein―Barr virus. Methodology. This article illustrates the experience of managing a patient with exudative-hyperemic form of lichen planus associated with Epstein―Barr virus and the inclusion of antiviral drugs in the treatment regimen. The paper used clinical and laboratory methods for diagnosing the conditions under study. Results. In the course of the observation, a positive clinical and laboratory dynamics of the conditions under study was revealed when applying the modernized treatment plan for lichen planus. The appointment of systemic and local antiviral therapy can reduce the treatment time for lichen planus on the mucous membrane of the oral cavity and not resort to the appointment of local hormone therapy. Conclusions. In order to increase the effectiveness of the therapy for lichen planus, it is necessary to conduct a study to identify specific DNA not only for Epstein―Barr virus, but also for all herpes viruses due to immunotropy and persistence mainly in the cells of the oral mucosa. The use of a systemic antiviral component reduces the treatment time for dental manifestations of lichen planus and eliminates the need for corticosteroid therapy, which improves the quality of life of patients.
lichen planus, herpesvirus infection, Epstein-Barr virus, papules, glossitis, antiviral therapy, hormone therapy
1. Letaeva, O. V. (2012). Kliniko-patogeneticheskaya kharakteristika bol'nykh krasnym ploskim lishayem i obosnovaniye terapii : avtoref. dis. … kand. med. nauk [Clinical and pathogenetic characteristics of patients with red flat ringworm and rationale for therapy : abstract. dis. cand. med. sciences]. Yekaterinburg, 27. (In Russ.)
2. Snarskaja, E. S., Proskurina, N. V., Bobrov, M. A. et al. (2013). Kliniko-morfologicheskiye osobennosti pigmentnoy formy krasnogo ploskogo lishaya [The clinical-morphological features of pigmented forms of lichen planus]. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney [Russian Journal of Skin and Venereal Diseases], 5, 40–43. (In Russ.)
3. Adamo, D., Ruoppo, E., Leuci, S. et al. (2014). Sleep disturbances, anxiety and depression in patients with oral lichen planus: a case-control study. J Eur Acad Dermatol Venereol.
4. Grigoryan, A. A., Sirak, S. V. (2013). Razrabotka i klinicheskoye primeneniye novogo ranozazhivlyayushchego sredstva dlya lecheniya zabolevaniy slizistoy obolochki polosti rta u detey i podrostkov [Development and clinical application of a new wound healing agent for the treatment of diseases of the oral mucosa in children and adolescents]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education], 4, 67–41. (In Russ.)
5. Yildirim, B., Senguven, B., Demir, C. (2011). Prevalence of Herpes simplex, Epstein Barr and Human papilloma viruses in oral lichen planus. Med. Oral Patol. Oral Cir. Bucal, 16, 2, 170–174.
6. Vikulov, G. H. (2014). Gerpesvirusnyye infektsii cheloveka v novom tysyacheletii: klassifikatsiya, epidemiologiya i mediko-sotsial'noye znacheniye [Human Herpesvirus infections in the new Millennium: classification, epidemiology and medical and social significance]. Epidemiologiya i infektsionnyye bolezni [Epidemiology and infectious diseases], 3, 342–343. (In Russ.)
7. Granitov, P. M. (2001). Gerpesvirusnaya infektsiya [Herpesvirus infection]. N. Novgorod : NGMA, 343. (In Russ.)
8. Malashenkova, I. K., Didkovsky, N. A. (2007). Klinicheskiye formy khronicheskoy Epshteyn-Barr-virusnoy infektsii: voprosy diagnostiki i lecheniya [Clinical forms of chronic Epstein-Barr virus infection: issues of diagnosis and treatment]. Novosti meditsiny i farmatsii [News of medicine and pharmacy], 14, 541–547. (In Russ.)
9. Orlov, S. N., Machines, S. A., Vernikov, O. R. et al. (2009). Sovremennyye aspekty diagnostiki ostroy virusnoy infektsii Epshteyna-Barr [Modern aspects of diagnosis of acute viral infections Epstein-Barr]. Vestnik Ivanovskoy meditsinskoy akademii [Bulletin of the Ivanovo medical Academy], 4, 79–84. (In Russ.)
10. Uchaykin, V. F., Shamsheva, O. V. (2001). Vaktsinoprofilaktika. Nastoyashcheye i budushcheye [Vaccination. The present and the future]. Moscow : GEOTAR-MED, 245. (In Russ.)
11. Akanitapichat, P., Lowden, C. T., Bastow, K. F. (2000). 1,3–Dihydroxyacridone derivatives as inhibitors of herpes virus replication. Antiviral Res, 45, 2, 123–134.
12. Spruance, S. L., Kriesel, J. D. (2002). Treatment of Herpes Simplex Labials, Herpes, 9, 3, 64–69.
13. Guryevskaya, O. A., Hismatullina, Z. R., Usmanova, I. N. et. al. (2020). Otsenka osobennostey klinicheskikh proyavleniy i kachestva zhizni u patsiyentov s razlichnymi formami krasnogo ploskogo lishaya slizistoy obolochki rta [Evaluation of clinical manifestations and quality of life in patients with various forms of red flat lichen of the oral mucosa]. Problemy stomatologii [Actual problems in dentistry], 15, 4, 38–43. (In Russ.)
14. Ivanova, I. N., Mansurov, R. A. (2003). Psikhosomaticheskoye sostoyaniye bol'nykh krasnym ploskim lishayem [Psychosomatic state of patients with lichen planus]. Vestn. dermatol. i venerol [Bulletin of dermatology and venereology], 5, 28–31. (In Russ.)
15. Molochkov, V. A., Prokofiev, A. A., Bobrov, M. A. (2011). Klinicheskiye osobennosti razlichnykh form krasnogo ploskogo lishaya [Clinical features of various forms of lichen planus]. Rossiyskiy zhurnal kozhnykh i venerologicheskikh bolezney [Russian journal of skin and venereal diseases], 1, 30–36. (In Russ.)
16. Rohn, G. I., Akmalova, G. M. (2014). Rol' virusnoy infektsii v razvitii krasnogo ploskogo lishaya slizistoy obolochki polosti rta [The role of viral infection in the development of red lichen planus of the oral mucosa]. Parodontologiya [Periodontology], 19, 1, 24–26. (In Russ.)
17. Fazylova, Yu. V., Musharapova, S. I. (2014). Krasnyy ploskiy lishay: proyavleniya v polosti rta. Sovremennyye printsipy diagnostiki i lecheniya : uchebnoye posobiye [Red lichen planus: manifestations in the oral cavity. Modern principles of diagnosis and treatment : textbook]. Kazan : Converse. 112. (In Russ.)
18. Anisimova, I. V., Zolotova, L. Yu., Lomiashvili, L. M. (2018). Kharakteristika dannykh anketirovaniya, mikrokristallizatsii i laboratornykh pokazateley rotovoy zhidkosti u patsiyentov s krasnym ploskim lishayem [Characteristics of questionnaire data, microcrystallization and laboratory indicators of oral fluid in patients with lichen planus]. Problemy stomatologii [Actual problems in dentistry], 14, 1, 5–10. (In Russ.)
19. Gerasimova, A. A., Kabirova, M. F., Gerasimova, L. P. (2017). Uroven' sensibilizatsii k allergenam gribkovoy etiologii i sostoyaniye mestnogo immuniteta pri zabolevaniyakh slizistoy obolochki polosti rta [The level of sensitization to allergens of fungal etiology and the state of local immunity in diseases of the oral mucosa]. Problemy stomatologii [Actual problems in dentistry], 13, 1, 56–60. (In Russ.)
20. Torrente-Castells, E. (2010). Clinical features of oral lichen planus. A retrospective study of 65 cases. Medicina Oral, Patología Oral Y Cirugía Bucal, 15, 5, 685–690.
21. Zaraa, I., Mahfoudh, A., Sellami, M. K. et al. (2013). Lichen planus pemphigoides: four new cases and a review of the literature. Int J of Dermatol, 52, 406–412.
22. Gileva, O. S., Libik, T. V., Khachilaev, E. V. (2011). Stomatologicheskoye zdorov'ye v kriteriyakh kachestva zhizni [Dental health in the criteria of quality of life]. Meditsinskiy vestnik Bashkortostana [Medical Bulletin of Bashkortostan], 3, 6–11. (In Russ.)
23. Young, L. S., Yap, L. F., Murray, P. G. (2016). Epstein-Barr virus: more than 50 years old and still providing surprises. Nat. Rev. Cancer, 16, 789–802.
24. Thorley-Lawson, D. A., Hawkins, J. B., Tracy, S. I., Shapiro, M. (2013). The pathogenesis of Epstein-Barr virus persistent infection. Curr. Opin. Virol, 3, 227–232.
25. Hislop, A. D., Taylor, G. S., Sauce, D., Rickinson, A. B. (2007). Cellular responses to viral infection in humans: lessons from Epstein-Barr virus. Annu. Rev. Immunol, 25, 587–617.
