employee
employee
Russian Federation
employee
Russian Federation
employee
employee
Russian Federation
employee
Russian Federation
VAC 14.01.2000 Клиническая медицина
VAC 14.02.2004 Медицина труда
UDK 61 Медицина. Охрана здоровья
GRNTI 76.01 Общие вопросы медицины и здравоохранения
GRNTI 76.29 Клиническая медицина
OKSO 14.02.02 Радиационная безопасность
OKSO 31.06.2001 Клиническая медицина
OKSO 31.07.01 Клиническая медицина
OKSO 32.08.09 Радиационная гигиена
BBK 54 Клиническая медицина
BBK 56 Клиническая медицина
BBK 58 Прикладные отрасли медицины
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
TBK 5734 Медицинская радиология и рентгенология
TBK 577 Другие отрасли медицины
BISAC MED080000 Radiology, Radiotherapy & Nuclear Medicine
Purpose: To present descriptive characteristics, and structure of the chronic radiation sickness (CRS) registry prospects of its use. Materials and methods: A registry for CRS diagnosed in workers of the nuclear production facility Mayak Production Association (PA) throughout the follow-up period of 1948–2018 was established within a medical and dosimetry database ‘Clinic’ of the Southern Urals Biophysics Institute. Results: The CRS registry includes 2068 cases: 1517 (73.4 %) in males and 551 (26.6 %) in females. Almost all workers (97.9 %) with CRS were hired at the Mayak PA in 1948–1954 and chronically externally and/or internally exposed to ionizing radiation. At a date of CRS diagnosis the mean cumulative red bone marrow absorbed dose of external exposure to gamma rays was 1.1 ± 0.7 Gy in males and 1.0 ± 0.6 Gy in females; the mean annual dose was 0.46 ± 0.33 Gy and 0.38 ± 0.22 Gy in males and females, respectively; maximum annual dose was 0.67 ± 0.46 Gy and 0.55 ± 0.34 Gy in males and females, respectively. The CRS frequency in the Mayak PA worker cohort significantly increased with the cumulative and mean annual RBM absorbed dose of external exposure to gamma rays. In the meantime, the CRS frequency was not associated either with a dose of external neutron exposure or with a dose of internal exposure to alpha particles from incorporated plutonium. Conclusion: The established CRS registry providing complete high quality demographical, medical and dosimetry information, together with available biological specimens, in future will allow: the updating of dose–response and dose–time–response relationships; the estimation of latent periods, risks and dose thresholds and associated uncertainties for CRS development; certain tissue reactions in lymphoid and haematopoietic tissues; and a better understanding of their development patterns and mechanisms, taking into account non-radiation factors.
chronic gamma-ray exposure, chronic radiation sickness, red bone marrow, occupational radiation exposure, Mayak PA
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