employee
Ufa, Ufa, Russian Federation
employee
Ufa, Ufa, Russian Federation
UDK 6160 Педиатрия в целом
GRNTI 76.01 Общие вопросы медицины и здравоохранения
GRNTI 76.29 Клиническая медицина
OKSO 31.07.01 Клиническая медицина
BBK 53 Клиническая медицина в целом
BBK 54 Клиническая медицина
BISAC MED016000 Dentistry / General
To date, there is a limited amount of literature that describes the features of the microbial composition of plaque in patients with a confirmed diagnosis of SARS-CoV-2. Therefore, this topic is relevant today. Thus, the purpose of this study was to study the characteristics of the microbial composition of dental plaque in patients with a laboratory-confirmed diagnosis of SARS-CoV-2 of mild to moderate severity, with the presence of concomitant oral coinfection or its absence. Knowledge of the features of the microbial composition of dental plaque in patients with Sars-CoV-2, as well as timely treatment of inflammatory diseases of the oral cavity will constitute an important stage in the algorithm of specialized therapy. The work carried out a comprehensive assessment of the features of the microbial composition of dental plaque in patients with a confirmed diagnosis of SARS-CoV-2. The conclusions are based on the results of a clinical study, which compared the characteristics of the microbial composition of dental plaque in 90 patients aged 20 to 65 years with mild to moderate Sars-CoV-2 with oral coinfection and 15 aged 20 to 65 years with mild to moderate Sars-CoV-2 with no coinfection. Results. In the course of the study, the following results were obtained. Patients with + coinfection had a severe course of the disease, transfer to the NIVL was more often required; the duration of hospitalization increased; longer treatment and long-term rehabilitation was required, aimed at normalizing indicators and normalizing the microflora. Based on this, it can be assumed that the presence of oral coinfection affects the severity of the condition and the course of Sars-CoV-2. This means that the risk of coinfection, secondary infection should be taken into account. And, finally, knowledge of the mechanisms of interaction of viruses, fungi and bacteria gives hope for the creation of drugs that will effectively resist even such combined attacks. Conclusions. The available evidence suggests that the oral cavity may be an active focus of infection and an important reservoir of SARS-CoV-2.
SARS-CoV-2, coronavirus, oral cavity, coinfection, plaque
1. Al' Kofish M., Usmanova I.N., Husnarizanova R.F., Kuznecova L.I., Gumerova M.I., Usmanov I.R., Sarvalieva A.F. Ocenka markerov razvitiya zabolevaniy parodonta na osnovanii izucheniya mikrobnogo sostava razlichnyh biotopov polosti rta. Problemy stomatologii. 2021;4:40-45. [M. Al Kofish, I.N. Usmanova, R.F. Khusnarizanova, L.I. Kuznetsova, M.I. Gumerova, I.R. Usmanov, A.F. Sarvalieva. Different biotopes of the oral cavity. Actual problems in Dentistry. 2021;4:40-45. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-16-4-40-45
2. Bandara H.M.H.N., Samaranayake L.P. Viral, bacterial, and fungal infections of the oral mucosa: Types, incidence, predisposing factors, diagnostic algorithms, and management // Periodontology 2000. – 2019;80(1):148-176. https://doi.org/10.1111/prd.12273
3. Bartlett J.G. Diagnostic Tests for Agents of Community-Acquired Pneumonia // Clinical Infectious Diseases. – 2011;52(4):S296-S304. DOI:10.1093/cid/cir045
4. Bassis C.M., Erb-Downward J.R., Dickson R.P., Freeman C.M., Schmidt T.M., Young V.B. Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals // mBio. – 2015;3;6(2):e00037.DOI:10.1128/mBio.00037-15
5. Carvalho T. COVID-19 Research in Brief: December, 2019 to June, 2020 // Nat Med. – 2020;26:1152-1156. DOI: 10.1038/d41591-020-00026-w
6. Dewhirst F.E., Chen T., Izard J., Paster B.J., Tanner A.C., Yu W.H. et al. The human oral microbiome // J Bacteriol. – 2010;192(19):5002-5017. DOI:10.1128/JB.00542-10
7. Jorgensen J.H., Ferraro M.J. Antimicrobial Susceptibility Testing: AReview of General Principles and Contemporary Practices // Clin. In-fect. Dis. – 2009;49(11):1749-1755. DOI:10.1086/647952
8. Hao Xu, Liang Zhong, Jiaxin Deng, Jiakuan Peng, Hongxia Dan, Xin Zeng et al. High expression of the ACE2 2019-nCoV receptor on epithelial cells of the oral mucosa // Int J Oral Sci. – 2020;12:1-5. DOI: 10.1038/s41368-020-0074-x
9. Huang S., Wang Wu., Li X., Ren L., Zhao J., Hu W. et al. Clinical features of patients infected with the new 2019 coronavirus in Wuhan // Lancet. – 2020;15;395(10223):497-506. DOI:10.1016/S0140-6736(20)30183-5
10. Hui D.S.C., Zumla A. Review of severe acute respiratory syndrome: historical, epidemiological and clinical features // Infect Dis Clin North Am. – 2019;33(4):869-889. DOI: 10.1016/j.idc.2019.07.001
11. Greene J.G., Vermillion J.R. The Simplified Oral Hygiene Index // The Journal of the American Dental Association. – 1964;68(1):7-13. DOI:10.14219/jada.archive.1964.0034
12. Koh H.W., Kim M.S., Lee J.S., Kim H., Park S.J. Microbes Environ // Changes in swine gut microbiota in response to swine epidemic diarrhea. – 2015;30(3):284-287. DOI:10.1264/jsme2.ME15046
13. Khan A.A., Khan Z. COVID-2019-associated overexpressed Prevotella proteins mediated host-pathogen interactions and their role in the coronavirus outbreak // Bioinformatics. – 2020;1;36(13):4065-4069. DOI:10.1093/bioinformatics/btaa285
14. Lan L., Xu D., Ye G. et al. Positive RT-PCR test results in patients who recovered from COVID-19 // JAMA. – 2020;323:1502. doi: 10.1001/jama.2020.2783.
15. Medvedeva L.S., Suvorova M.G. Methods of microbiological diagnostics for diseases of vapor and periodont // International student scientific bulletin. – 2018;6. URL : http://eduherald.ru/ru/article/view?id=19262 DOI: 10.1001/jama.2020.2783).
16. Mammen M.J., Scannapieco F.A., SethiS. Oral-lung microbiome interactions in lung diseases // Periodontol 2000. – 2020;83(1):234-224. DOI:10.1111/prd.12301
17. Petersen P.E. The World Oral Health Report 2003: continuous improvement of oral health in the 21st century-the approach of the WHO Global Oral Health Programme // Community Dent Oral Epidemiol. – 2003;31:3-23. DOI:10.1046/j..2003.com122.x
18. Patel J., Sampson W. The role of oral bacteria in COVID-19 // Lanceolate Microbe. – 2020;1:e105. doi: 10.1016/S2666-5247(20)30057-4
19. Kitamoto S., Nagao-Kitamoto H., Jiao Y. et al. Intermucosal connection between the mouth and the intestine in commensal pathobiontic colitis // Cell. – 2020;182:447-462. DOI:10.1016/S2666-5247(20)30057-4
20. O pereprofilirovanii medicinskih organizaciy v gospital'nye bazy g. Ufy (s izm. ot 13.04.2020 g. № 318-A). [On the re-profiling of medical organizations into hospital bases in the city of Ufa (as amended on April 13, 2020, No. 318-A). (In Russ.)]. URL : https://bashgmu.ru
21. Russell A.L. A System of Classification and Scoring for Prevalence Surveys of Periodontal Disease // Journal of Dental Research. – 1956;35(3):350-359. DOI:10.1177/00220345560350030401
22. Segal L.N., Alekseyenko A.V., Clemente J.C., Kulkarni R., Wu B., Gao Z. Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary // Microbiome. – 2013;1;1(1):19. DOI:10.1186/2049-2618-1-19
23. Shour I., Massler M. Gingival disease in Postwar Italy(1945): prevalence of gingivitis in various coe groups // J AmDentAssoc, Chicago.Aug. – 1947;35;2:475-482. DOI:10.14219/jada.archive.1947.0266
24. Yi Q., Fan S., Lv J., Zhang X., Guo L., et al. Characterization of subsets of lymphocytes and cytokines in the peripheral blood of 123 hospitalized patients with novel coronavirus pneumonia in 2019 medRxiv. DOI:10.1101/2020.02.10.20021832
25. Zhu N., Zhang D., Wang W., Li X., Yang B., Song J., Zhao X. et al. A Novel Coronavirus from Patients with Pneumonia in China 2019], [Published in China] Novel Coronavirus Investigating and Research Team // N Engl J Med. – 2020;20;382(8):727-733. DOI:10.1056/NEJMoa2001017
26. Zhou F., Yu T., Du R. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study // Lancet. – 2020;395(10229):1054-1062. DOI:10.1016/S0140-6736(20)30566-3
