Ufa, Ufa, Russian Federation
Sterlitamak, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
employee
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
employee
Ekaterinburg, Ekaterinburg, Russian Federation
Lichen planus is considered as a multifactorial disease. Various factors play a role in the development of lichen planus of the oral mucosa: genetic, dental materials that are used for restoration, prosthetics of teeth, Helicobacter pylori, viruses, psychological stress, somatic pathology and others. The pathogenesis of oral lichen planus is based on an autoimmune process. The aim of the study was to determine the immunological reactivity in patients with various clinical forms of lichen planus of the oral mucosa. The study carried out clinical, laboratory examination of 75 female patients aged 29 to 75 years old with red lichen planus of the oral mucosa. All patients were divided into three groups depending on the clinical form of the disease. The control group consisted of 30 women aged 39 to 70 years old without red lichen planus of the oral mucosa. The phagocytic activity of neutrophils, the level of immunoglobulins of classes A, M, G and circulating immune complexes in the blood serum were evaluated. The humoral link of immunity in patients with exudative-hyperemic form of OLP was characterized by hyperimmunoglobulinemia of classes A, M, G, an increase in circulating immune complexes, in patients with erosive-ulcerative form of hyperimmunoglobulinemia of class M against the background of hypoimmunoglobulinemia A, G and an increase in circulating immune complexes. In patients with a typical form of OLP, only an increase in the level of circulating immune complexes was noted. When assessing the immune reactivity in patients with OLP, the relationship between the manifestations of the "dysphagocytosis" syndrome, disorders in the humoral immunity system with various clinical forms of the disease was established. This fact allows us to conclude about the pathogenetic role of an imbalance in the system of mechanisms that ensure the elimination of pathogens, including infectious nature in the occurrence of a disease with the formation of an autoimmune component.
lichen planus, oral mucosa, immunological reactivity, pathogenesis, autoimmune process
1. Akmalova G.M., Chuykin S.V., Ron' G.I., Chernysheva N.D., Galimova E.S., Gilyazova I.R., Husnutdinova E.K. Primenenie geneticheskih markerov v prognozirovanii razvitiya i recidiva krasnogo ploskogo lishaya slizistoy obolochki rta. Problemy stomatologii. 2016;12(1):62-69. [G.M. Akmalova, S.V. Chuikin, G.I. Ron, N.D. Chernysheva, E.S. Galimova, I.R. Gilyazova, E.K. Khusnutdinova. Application of genetic markers in predicting the development and recurrence of lichen planus of the oral mucosa. Actual problems in dentistry. 2016;12(1):62-69. (In Russ.)]. https://www.elibrary.ru/item.asp?id=25781406
2. Anisimova I.V., Simonyan L.A. Chastota sochetaniya krasnogo ploskogo lishaya s somaticheskoy patologiey i mestnymi neblagopriyatnymi faktorami polosti rta. Problemy stomatologii. 2019;15(1):16-22. [I.V. Anisimova, L.A. Simonyan. The frequency of the combination of lichen planus with somatic pathology and local adverse factors of the oral cavity. Actual problems in dentistry. 2019;15(1):16-22. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37602574
3. Gur'evskaya O.A., Livzan M.A., Usmanova I.N., Hismatullina Z.R., Chepurkova O.A., Granot I., Tiunova N.V., Berezin K.A. Nekotorye osobennosti klinicheskoy manifestacii tipichnyh i oslozhnennyh form krasnogo ploskogo lishaya na slizistoy obolochke rta po dannym nablyudeniya. Problemy stomatologii. 2021;17(1):63-69. [O.A. Guryevskaya, M.A. Livzan, I.N. Usmanova, Z.R. Hismatullina, O.A. Chepukova, Y. Granot, N.V. Tiunova, K.A. Berezin. Some features of clinical manifestation of typical and complicated forms of lichen planus on the oral mucosa according to observation data. Actual problems in dentistry. 2021;17(1):63-69. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-17-1-63-69
4. Ron' G.I., Epishova A.A. Vliyanie haraktera pitaniya na techenie krasnogo ploskogo lishaya slizistoy polosti rta. Problemy stomatologii. 2015;2:19-23. [G.I. Ron, A.A. Epishova. The impact of nutrition on the course of lichen planus. Actual problems in dentistry. 2015;2:19-23. (In Russ.)]. https://elibrary.ru/item.asp?id=23731231
5. Ron' G.I., Pomazkina A.A. Klinicheskiy sluchay razvitiya krasnogo ploskogo lishaya na slizistoy obolochke polosti rta u muzhchiny molodogo vozrasta, dlitel'no rabotayuschego s personal'nym komp'yuterom. Problemy stomatologii. 2016;12(2):50-54. [G.I. Ron, A.A. Pomazkina. A clinical case of the development of lichen planus on the mucous membrane of the oral cavity in a young man who has been working with a personal computer for a long time. Actual problems in dentistry. 2016;12(2):50-54. (In Russ.)]. https://www.elibrary.ru/item.asp?id=26324572
6. Usmanova I.N., Hismatullina Z.R., Granot I., Ahmerov R.R., Abdrahmanova E.R., Husnarizanova R.F., Usmanov I.R., Mudrik O.V., Gerasimova L.P. Ocenka rezul'tatov kompleksnoy terapii krasnogo ploskogo lishaya slizistoy obolochki rta s ispol'zovaniem autologichnoy plazmy i gidrolizata placenty cheloveka. Problemy stomatologii. 2019;15(2):37-44. [I.N. Usmanova, Z.R. Khismatullina, I. Granot, R.R. Akhmerov, E.R. Abdrakhmanova, R.F. Khusnarizanova, I.R. Usmanov, O.V. Mudrik, L.P. Gerasimova. Evaluation of the results of complex therapy of lichen planus of the oral mucosa using autologous plasma and hydrolyzate of the human placenta. Actual problems in dentistry. 2019;15(2):37-44. (In Russ.)]. https://www.elibrary.ru/item.asp?id=39165960
7. Chuykin S.V., Akmalova G.M., Chernysheva N.D. Osobennosti klinicheskogo techeniya krasnogo ploskogo lishaya slizistoy obolochki rta, associirovannogo s gerpesvirusnoy infekciey. Sovremennye problemy nauki i obrazovaniya. 2015;2-1:80. [S.V. Chuikin, G.M. Akmalova, N.D. Chernysheva. Clinical features of lichen planus of the oral mucosa associated with herpesvirus infection. Modern problems of science and education. 2015;2-1:80. (In Russ.)].
8. Chuykin S.V., Akmalova G.M., Chernysheva N.D. Harakteristika mikroflory polosti rta u bol'nyh s krasnym ploskim lishaem. Parodontologiya. 2014;19(4):41-43. [S.V. Chuikin, G.M. Akmalova, N.D. Chernysheva. Characteristics of the microflora of the oral cavity in patients with lichen planus. Periodontics. 2014;19(4):41-43. (In Russ.)]. https://www.elibrary.ru/item.asp?id=22872760
9. Ahmed I., Nasreen S., Jehangir U., Wahid Z. Frequency of oral lichen planus in patients with noninsulin dependent diabetes mellitus // J Pak Assoc Derm. – 2012;22:30-34.
10. Bajaj D.R., Khoso N.A., Devrajani B.R., Matlani B.L., Lohana P. Oral lichen planus: A clinical study // J Coll Physicians Surg Pak. – 2010;20:154-157. PMID: 20392375.
11. Campisi G., Giovannelli L., Aricò P., Lama A., Di Liberto C., Ammatuna P. et al. HPV DNA in clinically different variants of oral leukoplakia and lichen planus // Oral Surg Oral Med Oral Pathol Oral Radiol Endod. – 2004;98:705-711. doi: 10.1016/j.tripleo.2004.04.012.
12. Canto A.M., Müller H., Freitas R.R., Santos P.S. Oral lichen planus (OLP): Clinical and complementary diagnosis // An Bras Dermatol. – 2010;85:669-675. DOI:10.1590/S0365-05962010000500010
13. Georgakopoulou E.A., Achtari M.D., Achtaris M., Foukas P.G., Kotsinas A. Oral lichen planus as a preneoplastic inflammatory model // J Biomed Biotech. – 2012;12:1-9. DOI: 10.1155/2012/759626
14. Gorsky M., Epstein J.B. Oral lichen planus: Malignant transformation and human papilloma virus: A review of potential clinical implications // Oral Surg Oral Med Oral Pathol Oral Radiol Endod. – 2011;111:461-464. doi: 10.1016/j.tripleo.2010.11.007.
15. Griffith M., Kaufman H.S., Silverman S. Studies on oral lichen planus: serum immunoglobulins and complement // J Dent Res. – 1974;53:623-626.
16. Gupta S., Jawanda M.K. Oral lichen planus: An update on etiology, pathogenesis, clinical presentation, diagnosis and management // Indian J Dermatol. – 2015;60:222-229. https://www.e-ijd.org/text.asp?2015/60/3/222/156315
17. Issa Y., Brunton P.A., Glenny A.M., Duxbury A.J. Healing of oral lichenoid lesions after replacing amalgam restorations: A systematic review // Oral Surg Oral Med Oral Pathol Oral Radiol Endod. – 2004;98:553-565. doi: 10.1016/j.tripleo.2003.12.027.
18. Lavanya N., Jayanthi P., Rao U.K., Ranganathan K. Oral lichen planus: An update on pathogenesis and treatment // J Oral Maxillofac Pathol. – 2011;15:127-132. http://dx.doi.org/10.4103/0973-029X.84474
19. Mehdipour M, Zenouz AT, Hekmatfar S, Adibpour M, Bahramian A, Khorshidi R. Prevalence of Candida species in erosive oral lichen planus. J Dent Res Dent Clin Dent Prospect 2010;4:14-6. . DOI:10.5681/joddd.2010.004
20. Moravvej H., Hoseini H., Barikbin B., Malekzadeh R., Razavi G.M. Association of Helicobacter pylori with lichen planus // Indian J Dermatol. – 2007;52:138-140. DOI:10.4103/0019-5154.35092
21. Scully C., Beyli M., Ferreiro M.C., Ficarra G., Gill Y., Griffiths M. et al. Update on oral lichen planus: Etiopathogenesis and management // Crit Rev Oral Biol Med. – 1998;9:86-122. DOI:10.1177/10454411980090010501
22. Scully C., Carrozzo M. Oral mucosal disease: Lichen planus // Br J Oral Maxillofac Surg. – 2008;46:15-21. DOI: 10.1016/j.bjoms.2007.07.199
23. Serrano-Sánchez P., Bagán J.V., Jiménez-Soriano, Sarrión G. Drug induced oral lichenoid reactions. A literature review // J Clin Exp Dent. – 2010;2:e71-75. doi:10.4317/jced.2.e71
24. Shivanandappa S.G., Ali I.M., Sabarigirinathan C., Mushannavar L.S. Candida in oral lichen planus // J Indian Aca Oral Med Radiol. – 2012;24:182-185. DOI:10.5005/jp-journals-10011-1291
25. Sklavounou A.D., Laskaris G., Angelopoulos A.P. Serum immunoglobulins and complement (C’3) in oral lichen planus // Oral Surg. Oral Med. Oral Pathol. – 1983;55:47-51. doi: 10.1016/0030-4220(83)90304-3.
26. Sugerman P.B., Satterwhite K., Bigby M. Autocytotoxic T-cell clones in lichen planus // Br J Dermatol. – 2000;142:449-456. doi: 10.1046/j.1365-2133.2000.03355.x.
27. Tarsariya V.M., Mehta D.N., Raval N., Patadiya H.H., Vachhrajani K., Ashem A. Evaluation of serum immunoglobulin (IgG, IgM, IgA) in potentially malignant disorders of oral cavity - A case control study // J Oral Biol Craniofac Res. – 2020;10(4):665-669. doi:10.1016/j.jobcr.2020.09.002
28. Vainio E., Huovinen S., Liutu M., Uksila J., Leino R. Peptic ulcer and Helicobacter pylori in patients with lichen planus // Acta Derm Venereol. – 2000;80:427-429. DOI: 10.1080/000155500300012855
29. Wray D., Rees S.R., Gibson J., Forsyth A. The role of allergy in oral mucosal leisons // QJM. – 2000;93:507-511. DOI: 10.1093/qjmed/93.8.507
30. Yildirim B., Senguven B., Demir C. Prevalence of herpes simplex, Epstein Barr and human papilloma viruses in oral lichen planus // Med Oral Patol Oral Cir Bucal. – 2011;16:e170-174. DOI:10.4317/medoral.16.e170
31. Zhou X.J., Sugarman P.B., Savage N.W., Walsh L.J., Seymour G.J. Intra-epithelial CD8+T cells and basement membrane disruption in oral lichen planus // J Oral Pathol Med. – 2002;31:23-27. doi: 10.1046/j.0904-2512.2001.10063.x.
