Knee injury leads to overproduction of free radicals and lipid peroxidation products, depression, endogenous antioxidant defense. This contributes to the expansion of the damaged area of cartilage and worsening destructive-dystrophic process in the joint. First-line non-steroidal anti-inflammatory drugs, which are cropped pain, do not affect the prognosis of the disease. Therefore it is advisable to include in the range of therapeutic interventions ozone therapy which has an antioxidant action. Some of the indicators of the lipid peroxidation and the activity of the endo-genous antioxidant system in case of isolated oral challenging of nimesulide, as well as in combination intra-articular ozonotherapy in post-traumatic arthritis had been studied in the experiment on the 95 non liner rats. These indicators were assessed at 3 and 28 days from the date of injury of the knee. It was found that a combined application of nimesu-lide and intra-articular ozonotherapy contributes to inhibition of lipid peroxidation and activation antioxidant system.
lipid peroxidation, antioxidant system, nimesulide, intra-articular ozonotherapy
1. Avdeeva O.S., Belyaeva E.A., Evlanova T.N., Novikova O.P., Savenkova N.A., Fedorishchev I.A., Bori-sova O.N., Yunina T.A. Otsenka vliyaniya farmakoterapii artronilom na klinicheskie proyavleniya osteoartroza kolennykh sustavov. Vestnik novykh me-ditsinskikh tekhnologiy. 2008. №1. S. 103–105.
2. Avdeeva O.S., Belyaeva E.A., Khadartsev A.A., Fedorishchev I.A. Opyt primeneniya lokal´noy applikatsionnoy terapii gialuronatsoderzhashchim gelem «Giasul´f» pri sustavnom sindrome. Vestnik novykh meditsinskikh tekhnologiy. 2008. № 4. S. 183–185.
3. Alekhina S.P., Shcherbatyuk T.G. Ozonoterapiya: klinicheskie i eksperimental´nye aspekty. N.Novgorod: «Litera», 2003. 240 s.
4. Badokin V.V. Mul´tifaktornost´ mekhanizmov deystviya nesteroidnykh protivovospalitel´nykh preparatov pri osteoartroze. Sovremennaya revmatologiya. 2009. №4. S. 81–87.
5. Belyaeva E.A., Kupeev V.G., Khadartsev A.A. Novaya tekhnologiya bezopasnoy analgeticheskoy terapii pri oslozhnennom osteoporoze. Vestnik novykh meditsinskikh tekhnologiy. 2010. №3. S. 122–124.
6. Belyaeva E.A., Fedorishchev I.A. Lazeroforez gialuronatsoderzhashchego gelya «Giasul´f» pri oslozhnennom postmenopauzal´nom osteoporoze. Vestnik novykh meditsinskikh tekhnologiy. 2010. №1. S. 36–38.
7. Dubrovin G.M., Blinkov Yu.A., Netyaga S.V., Netyaga A.A. Obosnovanie primeneniya mielopida dlya profilaktiki posttravmaticheskogo osteoartroza (eksperimental´noe issledovanie). Vestnik travmatologii i ortopedii im. N.N. Priorova. 2005. № 2. S. 60–62.
8. Karateev D.E. Nesteroidnye protivovospalitel´nye preparaty v terapii osteoartroza. Russkiy meditsinskiy zhurnal. 1997. Tom 5. № 15. S. 16–21.
9. Hogue J.H., Mersfelder T.L. Pathophysiology and first-line treatment of osteoarthritis. The Annals of Pharmacotherapy. 2002. Vol. 36. N. 4. P. 679–686.
10. Kulich W., Fagerer N., Schwann H. Effect of the NSAID nimesulide on the radical scavenger glutathione S-transferase in patients with osteoarthritis of the knee. Current Medical Research and Opinion. 2007. Vol. 23. N. 8. P. 1981-1986.
