Morphological Diagnosis of Endogenous Intoxication Using Biochemical Markers

S. Kalashnikova; V. Barkanov; A. Goryachev

doi:doi:10.12737/9078

Morphological Diagnosis of Endogenous Intoxication Using Biochemical Markers

Published в Journal of New Medical Technologies · Volume 22, Issue 1, 2015 · Pages 56–60 · Rubrics: Clinical Picture and Methods of Treatment. Functional and Instrumental Diagnostics. New Medicinal Forms

DOI 10.12737/9078

Received: 13.03.2015 Accepted: 13.03.2015 Published: 13.03.2015 Language of publication: RUS

Authors

S. Kalashnikova · V. Barkanov · A. Goryachev

ABSTRACT

Morphological diagnosis of endogenous intoxication in target organs - lung, liver and kidney, is unreliable due to lack of specific structural changes. To reliable diagnose of intoxication, the definition used in the tissue of the target organ indole, phenol and skatole, which are products of the activity of intestinal bacteria and penetrating into the systemic circulation together with bacterial lipopolysaccharide, can be used. The diagnostic accuracy can be estimated by reducing the brightness of the color micrographs of the investigated histological preparations in the system brightness RGB in the analysis of the micrographs in the program "Adobe Photoshop".Endogenous intoxication causes a statistically significant increase in the number indianola products, verified by the reaction of diazotization on histological sections in the cytoplasm of cells of the lungs, liver and kidneys. It can serve as a reliable diagnostic criterion for post-mortem morphological diagnosis of endogenous intoxication. The accumulation of indole, phenol and skatole in millionary partitions is detected at the endogenous intoxication in the lungs. In the liver, the toxic products found throughout the liver lobules. In the kidneys, indianola products accumulate in remoteley proximal tubules. Diagnostic value of research to target organs within the definition disapoiting substrate decreases in the series: liver>kidneys>lungs.

KEYWORDS

endogenous intoxication indole phenol skatole lung liver kidney

Information References

Authors:

Type:

Article

Pages:

from 56 to 60

Status:

Published

Language:

Russian

Keywords:

endogenous intoxication, indole, phenol, skatole, lung, liver, kidney

References

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