The paper presents the results of the retrospective analysis of data cards and histories of 953 women with an antenatal fetal death during 2010-2016 in the Crimea Republic. The aim of the research was to study the data of parity, gynecological and somatic history, features of pregnancy and childbirth in women with antenatal fetal death to identify significant risk factors for this pathology. According to the results of our study, women with antenatal losses did not reveal significant clinical and anamnestic risk factors for adverse perinatal outcomes. This once again confirms the lack of reliable methods for predicting antenatal fetal death in modern practical obstetrics. In spite of the significant progress made in the emergency protection of the child, the stillbirth is an important, insufficiently studied problem in the obstetrics. The high frequency of cases of antenatal fetal death with an unexplained cause requires further in-depth analysis and study of this problem, searching for the possibility of expanding the diagnostic potential of the methods used.
stillbirth, antenatal fetal death, causes, prophylaxis
1. 1. Khomenko V. A., Bezuglaya O. A., Mogilevkina I. A. Antenatal death: what the peculiarities of such pregnancies are? Tavricheskiy Mediko-Biologicheskiy Vestnik. 2012;15(2-2):201-203. (In Russ).
2. Silver R. M., Varner M. W., Reddy U., Goldenberg R., Pinar H., Conway D., Bukowski R., Carpenter M., Hogue C., Willinger M., Dudley D., Saade G., Stoll B. Work-up of stillbirth: a review of the evidence. American Journal of Obstetrics and Gynecology. 2007;196(5):433-444. doi: 10.1016/j. ajog.2006.11.041.
3. Pavlova T. V., Petrukhin V. A., Zhilyaeva O. D., Nadezhdin S. V. Placental morphology in pregnancy in the presence of iron-deficiency anemia. Archive of pathology. 2007;69(2):31-32. (In Russ).
4. Simpson L. L. Maternal medical disease: risk of antepartum fetal death. Seminars in Perinatology. 2002;26(1):42-50. doi:10.1053/sper.2002.29838.
5. Chu S. Y., Kim S. Y., Lau J., Schmid C. H., Dietz P. M., Callaghan W. M., Curtis K. M. Maternal obesity and risk of stillbirth: a metaanalysis. American Journal of Obstetrics and Gynecology. 2007;197(3):223-228. doi: 10.1016/j.ajog.2007.03.027.
6. Singer D. B., Macpherson T. A. Fetal death and the macerated stillborn fetus: textbook of fetal and perinatal pathology. Ed by Wigglesworth J. S., Singer D. B. 2 ed. Blackwell Science; 1998:233-250.
7. Fox H., Sebire N. Pathology of the Placenta. 3 ed. Saunders Elsevier; 2007.
8. Man J., Hutchinson J. C., Heazell A. E., Ashworth M., Jeffrey I., Sebire N. J. Stillbirth and intrauterine fetal death: role of routine histopathological placental findings to determine cause of death. Ultrasound in Obstetrics and Gynecology. 2016;48(5):579-584. doi:10.1002/ uog.16019.
9. Man J., Hutchinson J. C., Ashworth M., HeazellA. E., Jeffrey I., Sebire N. J. Stillbirth and intrauterine fetal death: contemporary demographic features of >1000 cases from an urban population. Ultrasound in Obstetrics and Gynecology. 2016;48(5):591-595. doi:10.1002/uog.16021.
10. Pacora P., Romero R., Jaiman S., Erez O., Bhatti G., Panaitescu B., Benshalom-Tirosh N., Jung E. J., Hsu C. D., Hassan S. S., Yeo L., Kadar N. Mechanisms of death in structurally normal stillbirths. Journal of Perinatal Medicine. 2019;47(2):222-240. doi:10.1515/ jpm-2018-0216.
11. Man J., Hutchinson J. C., Heazell A. E., Ashworth M., Levine S., Sebire N. J. Stillbirth and intrauterine fetal death: factors affecting determination of cause of death at autopsy. Ultrasound in Obstetrics and Gynecology. 2016;48(5):566-573. doi:10.1002/ uog.16016.
