Hetero-association of C60 fullerene with aromatic ligands: antitumour antibiotic doxorubicin and dyes proflavine and methylene blue, - was studied by UF/visible spectroscopy. The up-scaled hetero-association model was developed, in which formation of C60 clusters with different aggregate size was taken into account. The extinction coefficients of mixed solution and hetero-association constants were determined by analysis of experimental concentration dependences of differential absorption.
fullerene, doxorubicin, proflavine, methylene blue, ligand, hetero-association
1. Prylutska S., Grynyuk I., Matyshevska O., Prylutskyy Y.I., Ritter U., Scharff P. Anti-oxidant properties of C60 fullerenes in vitro. Fuller nanotub Carbon nanostr, 2008, vol. 16, no. 5-6, pp. 698-705.
2. Prylutska S., Burlaka A., Prylutskyy Y.I., Ritter U., Scharff P. Pristine C60 fullerenes inhibit the rate of tumor growth and metastasis. Exp Oncol., 2011, vol. 33, pp.162-164.
3. Prylutska S., Burlaka A., Prylutskyy Y.I. Comparative study of antitumor effect of pristine C60 fullerenes and doxorubicin. Biotechnol., 2011, vol. 4, no. 6, pp. 82-87.
4. Evstigneev M.P., Buchelnikov A.S., Voronin D.P., Rubin Y.V., Belous L.F., Prylutskyy Y., Ritter U. Complexation of C60 Fullerene with Aromatic Drugs. J. ChemPhysChem, 2013, vol. 14, pp. 568-578.
5. Prylutskyy Y.I., Petrenko V.I., Ivankov O.I., Kyzyma O.A., Bulavin L.A., Litsis O.O., Evstigneev M.P., Cherepanov V.V., Naumovets A.G., Ritter U. On the origin of C60 fullerene solubility in aqueous solution. Langmuir, 2014, vol. 30, pp. 3967-3970.
6. Prylutskyy Y.I., Buchelnikov A.S., Voronin D.P., Kostjukov V.V., Ritter U., Parkinson J. A., Evstigneev M. P. C60 fullerene aggregation in aqueous solution. Phys.Chem.Chem.Phys., 2013, vol. 15, pp. 9351-9360.
