CLAMP is Drosophila transcription factor involved in the recruitment of Dosage Compensation Complex. Spatial structure of N-terminal domain of CLAMP protein from Drosophila was studied using small-angle X-ray scattering (SAXS). This domain contains zinc-finger and adjacent amino-acid sequence with unknown structure. Earlier dimerization activity and binding of dosage compensation complex were shown for this domain. SAXS data confirm dimer formation and provide insight into the structure of the domain, which is folded, and have compact symmetrical structure.
multimerization, small-angle X-ray scattering, chromatin
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