GENERALIZED ‘UP-SCALED’ MODEL OF COMPLEXATION BETWEEN C60 FULLERENE AND ANTIBIOTIC DOXORUBICIN

A A Mosunov; D P Voronin; V A Salo; M A Sidorova; A S Buchelnikov

doi:doi:

UDC 577

GENERALIZED ‘UP-SCALED’ MODEL OF COMPLEXATION BETWEEN C60 FULLERENE AND ANTIBIOTIC DOXORUBICIN

Published в Russian Journal of Biological Physics and Chemisrty · Volume 3, Issue 4, 2018 · Pages 777–783 · Rubrics: Modelling in biophycis

Received: 20.12.2018 Accepted: 20.12.2018 Published: 25.12.2018 Language of publication: RUS

Authors

A A Mosunov ¹ · D P Voronin ² · V A Salo ³ · M A Sidorova ⁴ · A S Buchelnikov ⁵

1 Sevastopol State University

2 Sevastopol State University

3 Sevastopol State University

4 Sevastopol State University

5 Saint Petersburg State University

ABSTRACT

Previously published ‘up-scaled’ model of complexation in ‘C60 fullerene - Ligand’ system was critically analyzed. The equations of the generalized ‘up-scaled’ model accounting for the polydispersity of the mixture were derived. The approximation of the published experimental data of spectrophotometric titration in the ‘C60 fullerene - Doxorubicin’ system was carried out. The generalized model fits the minimum in the titration curve and gives a satisfactory quantitative evaluation of the complexation process. The model can be used in different studies of C60 fullerene as a drug delivery system to damaged cells.

KEYWORDS

aggregation C60 fullerene doxorubucin statistical-thermodynamic model

Information Text References

Authors:

1. Sevastopol State University

2. Sevastopol State University

3. Sevastopol State University

4. Sevastopol State University

5. Saint Petersburg State University

Type:

Article

Pages:

from 777 to 783

Status:

Published

Subject area:

UDC 577

Language:

Russian

Keywords:

aggregation, C60 fullerene, doxorubucin, statistical-thermodynamic model

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References

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GENERALIZED ‘UP-SCALED’ MODEL OF COMPLEXATION BETWEEN C60 FULLERENE AND ANTIBIOTIC DOXORUBICIN

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