Astrakhan, Astrakhan, Russian Federation
The present review shows that Escherichia coli and Proteus mirabilis belonging to the Enterobacteriaceae family, being the cause of human urinary tract infections, are characterized by the same factors of surface virulence, the ability to form biofilms, produce urease and α-hemolysin. Differing in the chemical composition of cell wall lipopolysarides, the functioning of quorum signaling systems, varieties of β-lactamases produced, the periodicity of «rowing» processes, invasive ability and tendency to interact with different types of cells make there no similarity in sensitivity to the action of antimicrobial drugs.Antimicrobial activity of quinazoline-4(3H)-ones substituted with azomethine group bound to benzene ring, nitro group, alcohol hydroxyl or covalent-bonded bromine atom, as well as heterocyclic radicals in relation to these pathogens is established. Ideas about the pharmacophoric activity of functional centers in the composition of various medicinal substances will allow modeling the structure of medicinal substances showing pharmacological effect against Escherichia coli and Proteus mirabilis.
urease, quinazoline-4(3H)-one, β-lactamases, quorum-signalling systems, antigenic determinant, Proteus mirabilis, Eschericihia coli, virulence factors, pharmacophore, autoinductors
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