Astrakhan, Astrakhan, Russian Federation
Copper complexes with aniline derivatives were synthesized and a comparative analysis of the anti-proliferative properties of the parent ligands and their complexes was carried out in relation to three tumor lines - MEL7, MCF-7, and PC3. A tendency towards the appearance and enhancement of the antiproliferative properties of compounds after complexation was revealed. The most active complex contained an o-F-substituted ligand, which causes activation of polyamine catabolism in a model of regenerating tissue, which shows the potential for such activation in tumor cells as well. This compound is recommended for further research.
Complex copper compounds, aniline derivatives, antiproliferative activity, screening, tumor cell lines
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