In this article the authors examine changes in the levels of tumor necrosis factor alpha and nitric oxide in the blood in patients with atrial fibrillation and hypertension. The study included 66 patients aged 60 to 75 years compared with the control group of 25 people. The results suggest that endothelial dysfunction is developed in patients. It is manifested by changes in the levels of tumor necrosis factor alpha and nitric oxide in the blood. The studied parameters can be the markers of severity and indicate a differentiated approach to various forms of atrial fibrillation. On the severity, an atrial fibrillation is clinically subdivided into paroxysmal, persis-tent and permanent (up to 30, 60 and 80 points, respectively).
atrial fibrillation, cytokines, nitric oxide, endothelial dysfunction, medico-social examination in points.
1. Aparina O.P., Chikhireva L.N., Mironova N.A., Mironova E.S., Bakalov S.A. Rol´ izmeneniy struktury i funktsii predserdiy v razvitii i progressirovanii fibrillyatsii predserdiy. Terapev-ticheskiy arkhiv. M.: MEDIA SFERA, 2014. S. 71–77.
2. Glants S. Mediko-biologicheskaya statistika. M.: Praktika, 1998. 459 s
3. Gorshunova N.K., Medvedev N.V., Tarasov A.N. Sootnoshenie apoptoza i endogennogo vospale-niya v patogeneze disfunktsii miokarda na fone arterial´noy gipertonii pri starenii. Fundamen-tal´nye issledovaniya. 2013. T.10, №2. S. 51–55.
4. Dedov D.V., Ivanov A.P., El´gard I.A. Vliyanie elektromekhanicheskogo remodelirovaniya serd-tsa na razvitie fibrillyatsii predserdiy u bol´nykh IBS i arterial´noy gipertenziey. Rossiyskiy Kardiologicheskiy Zhurnal. 2011. №4. S. 1–13.
5. Markov Kh.M. Oksid azota i ateroskleroz. Oksid azota, disfunktsiya sosudistogo endoteliya i patogenez ateroskleroza. Kardiologiya. 2009. № 11. S. 64–74.
6. Mitrofanova L.B., Platonov P.G. Morfologiya mezhpredserdnoy peregorodki i mezhpredserd-nykh soedineniy u bol´nykh s fibrillyatsiey predserdiy. Vestnik aritmologii. 2002. T.Kh, № 30. S. 43–49.
7. Rebrov A.P., Sazhina E.Yu., Toma M.I. Endotelial´naya disfunktsiya i osobennosti izmeneniya urovnya tsitokinov i S-reaktivnogo belka u bol´nykh khronicheskoy serdechnoy nedostatochnost´yu. Ros-siyskiy kardiologicheskiy zhurnal. 2005. T. 52, № 2. S. 26–31.
8. Rozhdestvenskiy M.E., Spinov V.I., Yurgel´ N.V. Mnogourovnevyy sistemnyy analiz na etapakh doklinicheskogo perioda khronicheskikh nespetsificheskikh zabolevaniy legkikh, Seriya «Profilakticheskaya pul´monologiya», Chast´ 111. Omsk: NP NIINMT, 2001. 46 s.
9. Rozhdestvenskiy M.E. Metodologiya diagnostiki doklinicheskogo perioda khronicheskikh nespetsificheskikh zabolevaniy legkikh.Seriya “Profilakticheskaya pul´monologiya”, Chast´ II. Omsk: NP NIINMT, 2000. 82 s.
10. Rozhdestvenskiy M.E. Khronicheskie bolezni nizhnikh dykhatel´nykh putey i sovremennaya tsivi-lizatsiya “Lambert Academic Publishinq”. AV Akademikerverlag GmbH, Saarbrucken, Germany, 2012. 60 p.
11. Terekhov I.V., Khadartsev A.A., Nikiforov V.S., Bondar´ S.S. Produktsiya tsitokinov kletkami tsel´noy krovi rekonvalestsentov vnebol´nichnoy pnevmonii pod vliyaniyam nizkointensivnogo SVCh-oblucheniya. Vestnik novykh meditsinskikh tekhnologiy. Elektronnoe izdanie. 2014. №1. Publikatsiya 2-57. URL: http://www.medtsu.tula.ru/VNMT/Bulletin/E2014-1/4815.pdf (Data obrashcheniya: 30.06.2014). DOI: 10.12737/5025
12. Khadartsev A.A., Logatkina A.V., Bondar´ S.S., Terekhov I.V. Vzaimosvyaz´ morfometricheskikh pokazateley miokarda s sostoyaniem ego vodosoderzhashchikh sred pri arterial´noy gipertenzii. Sbornik nauchnykh trudov Pervoy Mezhdunarodnoy zaochnoy nauchno-prakticheskoy konferentsii «Problemy razvitiya nauki, meditsiny, obrazovaniya (teoriya i praktika)» (Tula, 25 dekabrya 2013 g.) / Pod obshch. red. L.G. Varfolomeevoy. Tula, 2013. S. 79–84.
13. Bonow R.O. ACC/AHA Practice Guidelines. Circulation. 2006. Vol. 114. P. 84–231.
14. Granger D.L., Taintor R.R., Boockvar K.S., Hibbs J.B. Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction. Methods Enzymol. 1996. Vol. 268. P. 142–151
15. Green S.J., Pizzarello R.A., Padmanabhan V.T., Ong L.Y. Relation of angina pectoris to coronaiy ar-tery disease in aortic valve stenosis //Am. J. Cardiol. 2006. Vol.55. P.1063–1065.
16. Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005. Vol. 352. P. 1685–1695.
17. Bone formation and inflammation in cardiac valves / Mohler E.R., Gannon F., Reynolds C. [et al.]. Circulation. 2001. Vol. 103. P. 1522–1528.
18. Otto S.M. Textbook of clinical Echocardiography. St. Louis.: W.B. Saunders Company. 2000. 444 p
19. Pfeffer J.M., Pfeffer M.A., Braunwald E. Influence of chronic captopril therapy on the infracted left ventricle of the rat. Circulation Research. 1985. Vol. 57, № 1. P. 84–95.
