An increase of antibiotic resistance of bacteria, in particular, Streptococcus pneumoniae, has been registered recently in most developed countries. This necessitates the study of regional characteristics of etiological structure of causative bacterial agents of community-acquired pneumonia and their sensitivity to antibiotics. The aim of the study was to study the spectrum of bacterial pathogens of community-acquired pneumonia and the sensitivity of Streptococcus pneumoniae to antimicrobial agents in hospitalized patients in the Republic of North Ossetia - Alania. Bacteriological examination of sputum with definition of sensitivity of isolated strains of bacteria to antibiotics was performed in 270 patients with community-acquired pneumonia. According to our data, the main causative agent of community-acquired pneumonia in hospitalized patients in the Republic of North Ossetia-Alania is Streptococcus pneumoniae. III generation cephalosporins, respiratory fluoroquinolones, macrolides, showed high activity against Streptococcus pneumoniae isolated from hospitalized patients. Low activity of natural and semi-synthetic penicillins was shown. The obtained results allow optimizing of antimicrobial therapy of community-acquired pneumonia caused by Streptococcus pneumoniae.
community - acquired pneumonia, etiology, adult hospitalized patients, antimicrobial resistance, Streptococcus pneumoniae
1. Ignatova G.L., Antonov V.N., Kutsenko M.A. Diagnostika i lechenie vnebol´nichnoy pnevmonii. Prakticheskie rekomendatsii. RMZh, 2014. №25. S.1810-1816.
2. Karapetyan T.A. Vnebol´nichnaya pnevmoniya segodnya (obzor literatury). Vestnik Sankt–Peterburgskogo universiteta, 2008. №1. S.3-12.
3. Kozlov R.S. [i dr.]. Dinamika rezistentnosti Streptococcus pneumoniae k antibiotikam v Rossii za period 1999-2099 gg.. Klinicheskaya mikrobilogiya i antimikrobnaya khimioterapiya, 2010. №4. S.329-341.
4. Opredelenie chuvstvitel´nosti mikroorganizmov k antibakterial´nym preparatam (Metodicheskie ukazaniya MUK 4.2.1890-04) / Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya, 2004. T. 6, № 4. S.306-359.
5. Tsallagova O.T. [i dr.]. Antibakterial´naya terapiya vnebol´nichnoy pnevmonii v statsionarakh respubliki Severnaya Osetiya – Alaniya: farmakoepidemiologicheskoe issledovanie. Vladikavkazskiy mediko-biologicheskiy vestnik, 2013. №26. S.90-94.
6. Chuchalin A.G. [i dr.]. Vnebol´nichnaya pnevmoniya u vzroslykh: prakticheskie rekomendatsii po diagnostike, lecheniyu i profilaktike / Posobie dlya vrachey. Moskva, 2010. – 54 s.
7. Yakovlev S.V., Sidorenko S.V., Rafal´skiy V.V. Antibiotikorezistentnost´ kak ugroza natsional´noy bezopasnosti: fokus na meropriyatiya v ambulatorno-poliklinicheskom zvene zdravookhraneniya Rezolyutsiya. Spravochnik poliklinicheskogo vracha, 2014. №7. S.60-63.
8. Shorr A.F. et al. Azitromycin and survival in Streptococcus pneumoniae pneumonia: a retrospective study. BMJ, 2013. Vol.3. P.1-8.
