The informations about current opportunities therapy of bronchopulmonary dysplasia in children is presented in this review. Their assessment on the basis of the results of various studies carried out on the principles of evidence medicine was performed. The main achievements and problems in the treatment of bronchopulmonary dysplasia were revealed. The information about the principles of effective respiratory support, the principles of systemic and inhaled corticosteroids use, about the prospects for the late appointment of surfactant in children with bronchopulmonary dysplasia, etc. was presented. The questions of prevention and treatment of infectious complications of bronchopulmonary dysplasia were highlighted. The prospects of the therapy of this disease in children were determined.
bronchopulmonary dysplasia, therapy, children.
1. Babak O.A. i dr.. Bronkholegochnaya displaziya. Metodicheskie rekomendatsii / Pod red. akademika RAMN N.N. Volodina. M.: Izdatel´stvo GOU VPO «RGMU» Roszdrava, 2010. 56 s.
2. Baranov A.A. [i dr.]. Immunoprofilaktika tyazhelogo techeniya respiratorno-sintsitial´noy virusnoy infektsii u detey s bronkholegochnoy displaziey: rezul´taty chetyrekh epidemicheskikh sezonov. Pediatricheskaya farmakologiya, 2012. T.9. № 6. S.48-52.
3. Boytsova E.V., Bogdanova A.V., Ovsyannikov D.Yu. Posledstviya bronkholegochnoy displazii dlya respiratornogo zdorov´ya detey, podrostkov i molodykh vzroslykh. Voprosy diagnostiki v pediatrii, 2013. T.5. № 1. S.5-11.
4. Boytsova E.V. [i dr.]. Interstitsial´nye zabolevaniya legkikh u detey. Vestnik sovremennoy klinicheskoy meditsiny, 2014. T. 7. №6. S. 71-76.
5. Vauer R.R. Surfaktant v neonatologii. Profilaktika i lechenie respiratornogo distress-sindroma novorozhdennykh. M.: Meditsinskaya literatura, 2011. 96 s.
6. Geppe N.A. [i dr.]. Novaya rabochaya klassifikatsiya bronkholegochnykh zabolevaniy u detey. Doktor. Ru, 2009. № 1. S.7-13.
7. Gordeev V.I., Aleksandrovich Yu.S., Parshin E.V. Respiratornaya podderzhka u detey. SPb.: ELBI-SPb, 2009. 176 s.
8. Goryunov I.A., Dzhioev I.G. Parametry gemodinamiki v pervye dni zhizni novorozhdennykh zdorovykh i s respiratornym distress-sindromom. Vladikavkazskiy mediko-biologicheskiy vestnik, 2010. T.10. Vyp.17. S.36.
9. Degtyareva E.A. [i dr.]. Legochnaya gipertenziya i legochnoe serdtse u detey s bronkholegochnoy displaziey: faktory riska, diagnostika, vozmozhnosti terapii i profilaktiki. Pediatriya, 2013. № 5. S.32-39.
10. Zhirnov V.A., Ruzheynikova I.V., Shugurov D.A. Sindrom dykhatel´nykh rasstroystv kak faktor vysokogo riska razvitiya bronkholegochnoy patologii u detey. Aktual´nye problemy pediatrii: sbornik materialov XV Kongressa pediatrov Rossii s mezhdunarodnym uchastiem. M., 2011. S.288.
11. Ignat´eva V.I. [i dr.]. Kliniko-ekonomicheskiy analiz rezul´tatov programmy immunoprofilaktiki RSV-infektsii v epidemicheskiy sezon 2012/2013 gg. v Moskve. Pediatricheskaya farmakologiya, 2013. № 10. S.17-26.
12. Klassifikatsiya klinicheskikh form bronkholegochnykh zabolevaniy u detey. M.: Rossiyskoe respiratornoe obshchestvo, 2009. S.18.
13. Mezhinskiy S.S. [i dr.]. Klinicheskaya kharakteristika detey s bronkholegochnoy displaziey. Materialy I Mezhdunarodnogo Kongressa po perinatal´noy meditsine. M., 2011. 113 s.
14. Natsional´naya programma optimizatsii vskarmlivaniya detey pervogo goda zhizni v Rossiyskoy Federatsii. M., 2010. S. 86.
15. Ovsyannikov D.Yu. Terapiya i profilaktika bronkholegochnoy displazii: ot patogeneza k dokazatel´noy meditsine. Voprosy prakticheskoy pediatrii, 2009. T. 4. № 4. S. 30-40.
16. Ovsyannikov D.Yu., Degtyareva E.A. Kliniko-farmakoekonomicheskiy analiz terapii bronkholegochnoy displazii u detey pervykh trekh let zhizni. Rossiyskiy pediatricheskiy zhurnal, 2008. № 4. S.10-16.
17. Panov P.V. [i dr.]. Perinatal´nye faktory riska bronkholegochnoy displazii u detey. XXI Natsional´nyy Kongress po boleznyam organov dykhaniya. Ufa, 2011. S. 120–121.
18. Petrova N. A. [i dr.]. Apnoe i periodicheskoe dykhanie u novorozhdennykh detey s bronkholegochnoy displaziey. Pediatriya, 2009. T.87. № 1. S.13-18.
19. Rudakova A.V. Effektivnost´ zatrat na profilaktiku tyazheloy respiratorno-sintsitial´noy virusnoy infektsii u nedonoshennykh detey. Klinicheskaya farmakologiya i farmakoekonomika, 2010. T. 3 № 1. S. 13–18.
20. Sovremennye podkhody k profilaktike, diagnostike i lecheniyu bronkholegochnoy displazii. Pod red. A.A. Baranova. M.: Pediatr´´, 2013. 176 s.
21. Ctarevskaya S.V. Bronkholegochnaya displaziya: rezul´taty dlitel´nogo nablyudeniya. XVII Rossiyskiy natsional´nyy kongress «Chelovek i lekarstvo»: sbornik materialov kongressa (tezisy dokladov). M., 2010. S. 464-466.
22. Tatochenko V.K. Vaktsinatsiya nedonoshennykh i malovesnykh detey. Pediatricheskaya farmakologiya, 2013. T.10. № 4. S. 30-36.
23. Fedorova L.A. Nevrologicheskie iskhody nedonoshennykh detey s khronicheskoy patologiey legkikh. Voprosy prakticheskoy pediatrii, 2010. № 5. Prilozhenie 1. S. 87—88.
24. Abman S.H. Approach to the child with pulmonary hypertension and bronchopulmonary dysplasia. Advances in pulmonary hypertension, 2011; 10(2): 98-103.
25. Cerro M.J. et al. A consensus approach to the classification of pediatric pulmonary hypertensive vascular disease: Report from the PVRI Pediatric Taskforce, Panama 2011. Pulm. Circ., 2011; 1(2): 286-298.
26. Checchia P.A. et al. Mortality and morbidity among infants at high risk for severe respiratory syncytial virus infection receving prophilaxis with palivizumab: A systematic literature review and metaanalysis. Pediatr. Crit. Care. Med., 2011; 12(5): 580-8.
27. Greenough A. Role of ventilation in RSV disease: CPAP, ventilation, HFO, ECMO. Ped. Resp. Rev., 2009; 1(10): 26—28.
28. Halliday H.L., Ehrenkranz R.A., Doyle L.W. Late (>7 days) postnatal corticosteroids for chronic lung disease in preterm infants. Cochrane Database of Systematic Reviews, 2009; Art. No.: CD001145.
29. Henderson-Smart D.J., Davis P.G. Prophylactic methylxanthines for endotracheal extubation in preterm infants. Cochrane Database of Systematic Reviews, 2010; Art. No.: CD000139.
30. Henderson-Smart D.J., Steer P.A. Caffeine versus theophylline for apnea in preterm infants. Cochrane Database of Systematic Reviews, 2010; Issue 1. Art. No.: CD000273. DOI: 10.1002/14651858. CD000273.pub2.
31. Kersbergen K.J. et al. Hydrocortisone treatment for bronchopulmonary dysplasia and brain volumes in preterm infants. J. Pediatr., 2013; 163(3): 666-671.
32. Khemani E. et al. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics, 2007; 120(6): 1260-69.
33. Laughon M. et al. A Pilot Randomized, Controlled Trial of Later Treatment With a Peptide-Containing, Synthetic Surfactant for the Prevention of Bronchopulmonary Dysplasia. Pediatrics, 2009; 123; 89 DOI: 10.1542/peds.2007-2680.
34. Mourani P.M. et al. Effects of Long-term Sildenafil Treatment for Pulmonary Hypertension in Infants with Chronic Lung Disease. J. Pediatr., 2009; 154(3): 379–384.
35. Onland W. et al. Finding the Optimal Postnatal Dexamethasone Regimen for Preterm Infants at Risk of Bronchopulmonary Dysplasia: A Systematic Review of Placebo-Controlled Trials. Pediatrics, 2009; 123(1): 367-77.
36. Rojas-Reyes M.X., Morley C.J., Soll R.A. Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants. Cochrane Database of Systematic Reviews, 2012: CD000510.
37. Steinhorn R.H. et al. Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertension. J. Pediatr., 2009; 155: 841.
38. Stenson B., Brocklehurst P., Tarnow-Mordi W. Increased 36-week survival with high oxygen saturation target in extremely preterm infants. N. Engl. J. Med. 2011; 364: 1680–1682.
39. Sweet D.G. et al. European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants — 2010 update. Neonatology, 2010; 97: 402—417.
40. Finer N.N. et al. Early CPAP versus surfactant in extremely preterm infants. SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network. N. Engl. J. Med., 2010; 362: 1970–79.
