USE OF THE DRUG "PERPHTORAN" AND BIOACTIVE IMPLANTS WITH CALCIUM PHOSPHATE COATING IN SURGICAL TREATMENT OF FEMORAL NECK FRACTURES AT THE EXPERIMENT
Authors:
Type:
Article
Pages:
from 73
to 79
Status:
Published
Received:
28.09.2015
Accepted:
23.03.2017
Published:
15.09.2015
Language:
Russian
Keywords:
experiment, femoral neck, fractures, perftoran, osteosynthesis, calcium phosphate coating.
Abstract (English):
The purpose of the study was to improve the results of surgical treatment of femoral neck fractures by in-tra-osseous injection of oxygenated perphtoran in avascular femoral head and osteosynthesis implants with bioactive calcium phosphate coating in the experiment. Investigations were carried out on 68 male rabbits. Hip fracture was formed transcervically by osteotome and crosses private ligament of the femoral head. The authors studied the dynamics of radiological and morphological parameters of reparative osteogenesis in 3 groups of animals: the 1st group with the introduction of oxygenated perftoran in an avascular femoral head without osteosynthesis of the femoral neck; the 2nd group after osteosynthesis by implants with bioactive calcium phosphate coating; the 3rd group after injection of oxygenated perftoran in an avascular femoral head with osteosynthesis implants by bioactive calcium phosphate coating. In the group without osteosynthesis process the authors revealed the development of degenerative changes with bone resorption, the expansion of the fracture line, displacement of bone fragments and the formation of non-union of the femoral neck. Osteosynthesis of femoral neck fractures with calcium phosphate bioactive implants coating contributes to fracture healing. Analysis of the results of the morphological assessment of the perftoran effect of calcium phosphate coatings on reparative osteogenesis in experimental hip fracture allows to determine the less severe exudative phase of the inflammatory response and to accelerate bone formation in the group with oxygenated perftoran and titanium implants coated with calcium phosphate. Introduction of oxygenated perftoran in an avascular femoral head at the osteosynthesis of experimental hip fractures by bioactive implants coated with calcium phosphate promotes to bone regeneration processes on the basis of radiological and morphological data. This allows to fracture healing at an earlier date by reducing inflammatory infiltration in the area of the fracture and the direct inclusion of the implant with calcium phosphate coating in the process of reparative osteogenesis.
The purpose of the study was to improve the results of surgical treatment of femoral neck fractures by in-tra-osseous injection of oxygenated perphtoran in avascular femoral head and osteosynthesis implants with bioactive calcium phosphate coating in the experiment. Investigations were carried out on 68 male rabbits. Hip fracture was formed transcervically by osteotome and crosses private ligament of the femoral head. The authors studied the dynamics of radiological and morphological parameters of reparative osteogenesis in 3 groups of animals: the 1st group with the introduction of oxygenated perftoran in an avascular femoral head without osteosynthesis of the femoral neck; the 2nd group after osteosynthesis by implants with bioactive calcium phosphate coating; the 3rd group after injection of oxygenated perftoran in an avascular femoral head with osteosynthesis implants by bioactive calcium phosphate coating. In the group without osteosynthesis process the authors revealed the development of degenerative changes with bone resorption, the expansion of the fracture line, displacement of bone fragments and the formation of non-union of the femoral neck. Osteosynthesis of femoral neck fractures with calcium phosphate bioactive implants coating contributes to fracture healing. Analysis of the results of the morphological assessment of the perftoran effect of calcium phosphate coatings on reparative osteogenesis in experimental hip fracture allows to determine the less severe exudative phase of the inflammatory response and to accelerate bone formation in the group with oxygenated perftoran and titanium implants coated with calcium phosphate. Introduction of oxygenated perftoran in an avascular femoral head at the osteosynthesis of experimental hip fractures by bioactive implants coated with calcium phosphate promotes to bone regeneration processes on the basis of radiological and morphological data. This allows to fracture healing at an earlier date by reducing inflammatory infiltration in the area of the fracture and the direct inclusion of the implant with calcium phosphate coating in the process of reparative osteogenesis.
Keywords:
experiment, femoral neck, fractures, perftoran, osteosynthesis, calcium phosphate coating.
experiment, femoral neck, fractures, perftoran, osteosynthesis, calcium phosphate coating.
Современные методы лечения переломов шейки бедра (ТТТБ), несмотря на многочисленные экспериментальные и клинические работы, сопровождаются высокой частотой несращений (11,1-51,1%), асептического некроза головки бедра (6,1-43%), неблагоприятных исходов и инвалидности - до 36,7% [2,4,7-9].
Одним из патогенетически обоснованных способов уменьшения побочных эффектов применения имплантатов для остеосинтеза является использование биоактивных имплантатов, способных к инте-
