Russian Federation
Russian Federation
New reactions, which have been discovered and continue to be developed in A.E. Favorsky Irkutsk institute of chemistry SB RAS on the basis of acetylene, a product of oil, gas and coal processing and multi-faceted building block for organic synthesis, have been considered. These reactions provide for the shortest routes to construction of fundamental heterocyclic scaffolds (pyrroles, imidazoles, pyrazoles, indoles, pyridines, dihydropyridines, etc.) with desirable and optimum combination of functional pharmacophoric groups and fragments, which are responsible for antiviral (HIV, flu), antitumor, tuberculostatic and hypotensive activities.
acetylene and its derivatives, nitrogen-containing heterocycles, nucleophiles, zwitter-ions, atom-economic addition reactions, drug precursors
Создание новых методологий направленного синтеза высокоэффективных средств профилактики и лечения социально значимых заболеваний (сердечно-сосудистые и онкологические заболевания, туберкулёз, грипп, теросклероз, ВИЧ/СПИД-инфекция) относится к прорывным научным исследованиям, имеющим высокую степень реализации на мировом уровне. В Иркутском институте химии им. А.Е. Фаворского СО РАН (ИрИХ) эта фундаментальная задача решается в первую очередь на основе новых реакций ацетилена и его производных [1–6].
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