Россия
Проведен анализ результатов консервативного и паллиативного лечения онкологических больных с использованием локорегионарной гипертермии (ЛРГТ) самостоятельно или в комбинации с различными методами противоопухолевой терапии. Полученные данные показали, что ЛРГТ значимо повышает непосредственные результаты лучевой и/или химиотерапии, оказывает выраженный паллиативный эффект, в ряде случаев обеспечивает длительный локальный контроль. У некурабельных пациентов, исчерпавших «лимит» лучевой и/или химиотерапии, его использование с паллиативной целью возможно и в монорежиме.
локо-регионарная гипертермия, консервативная терапия, паллиативная терапия, термохимиотерапия, термолучевая терапия, обзор
1. Состояние онкологической помощи населению России в 2018 году (под редакцией А.Д. Каприна, В.В. Старинского, Г.В. Петровой). М.: МНИОИ им П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России. 2019. 236 стр. http://www.oncology.ru/service/statistics/[The state of oncological assistance to the population of Russia in 2018 (edited by A. Kaprin, VV. Starinsky and GV. Petrova). Moscow: Herzen Moscow Research Institute – a branch of the Federal State Budget Scientific Research Center for Radiology of the Russian Ministry of Health. 2019. 236 pp. (In Russ.)]. http://www.oncology.ru/service/statistics/]
2. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017. A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2019. E1-E20. September 27. DOI: https://doi.org/10.1001/jamaoncol.2019.2996.
3. Jemal A, Ward EM, Johnson CJ, Cronin KA, Ma J, Ryerson AB, Mariotto A, Lake AJ, Wilson R, Sherman RL, Anderson RN, Henley SJ, Kohler BA, Penberthy L, Feuer EJ, Weir HK. Annual Report to the Nation on the Status of Cancer, 1975–2014, Featuring Survival. J. of the National Cancer Institute. 2017;109(9):djx030. DOI: 10.1093/jnci/djx030.
4. Cancer Treatment & Survivorship Facts & Figures 2016-2017. Atlanta: American Cancer Society, 2016. Inc. No.865016.
5. Nahum AE. Converting Dose Distributions into Tumour Control Probability Radiation Dose in Radiotherapy from Prescription to Delivery. IAEA, A-1400 Vienna, Austria. 1996: 27-40.
6. Орлова Р.В., Вайзьян Р.И., Иванова А.К., Тихонова Е.К., Зорина Е.Ю. Химиотерапия злокачественных опухолей: проблемы и перспективы // Вопросы онкологии. 2015. № 2(61). С. 244-251. [Orlova RV, Vaizyan RI, Ivanova AK, Tikhonova EK, Zorina EY. Chemotherapy of Malignant Tumors: Problems and Prospects. Problems in Oncology. 2015;61(2):244-51. (In Russ.).]
7. Поддубная И.В., Орел Н.Ф. Побочные реакции и осложнения противоопухолевой лекарственной терапии. Руководство по химиотерапии опухолевых заболеваний (под ред. Н.И. Переводчиковой и В.А.Горбуновой). М.: Практическая медицина, 2011:425-446. [Poddubnaya IV, Oryol NF. Adverse Reactions and Complications of Antitumor Drug Therapy. Guidelines for the Chemotherapy of Tumor Diseases (ed. NI. Perevodchicova and VA. Gorbunova). Moskow. Practical medicine. 201:425-46. (In Russ.)]
8. Чубенко ВА. Осложнения таргетной терапии // Практическая онкология. 2010. № 3(11). С. 192-202. [Chubenko VA. Complications of Targeted Therapy. Practical Oncology. 2010;11(3):192-202. (In Russ.)]
9. De Angelis CD, Fontanarosa PB. Prescription Drugs, Products Liability, and Preemption of Tort Litigation. JAMA. 2008;300(16):1939-41.
10. Ставровская А.А, Генс Г.П. Некоторые новые аспекты исследований множественной лекарственной устойчивости опухолевых клеток // Успехи молекулярной онкологии. 2014. № 1(1). С. 5-11. doi:10.17650/2313-805X.2014.1.1.5-11.[Stavrovskaya AA, Gens GP. Some New Aspects of Studies of Multidrug Resistance of Tumor Cells. Advances in Molecular Oncology. 2014;1(1):5-11. (In Russ.)]. DOI: 10.17650 / 2313-805X.2014.1.1.5-11.
11. Трякин А.А., Федянин М.Ю., Покатаев И.А. 20 лет таргетной терапии солидных опухолей. Успехи и неудачи // Практическая онкология. 2018. № 3(19). С. 183-199. [Tryakin AA, Fedyanin MYu, Pokataev IA. 20 Years of Targeted Therapy of Solid Tumors. Success and Failure. Practical Oncology. 2018;19(3):183-99. (In Russ.)]
12. Zafar SY, Abernethy AP. Financial Toxicity, Part I: A New Name For A Growing Problem. Oncology (Williston Park). 2013;27(2):80-1.
13. Cheng Y, Weng S, Yu L, Zhu N, Yang M, Yuan Y. The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors. Integrative Cancer Therapies. 2019;18:1-11. DOI 10.1177/1534735419876345.
14. Курпешев О.К., Цыб А.Ф., Мардынский Ю.С., Бердов Б.А. Механизмы развития и пути преодоления химиорезистентности опухолей. Часть 4. Экспериментальные основы и практические результаты применения общей гипертермии в лечении химиорезистентных опухолей // Российский онкологический журнал. 2003. № 3. С. 50-53. [Kurpeshev OK, Tsyb AF, Mardynsky YS, Berdov BA. Mechanisms of development and ways of overcoming the chemoresistance of tumors. Part 4. Experimental foundations and practical results of the use of general hyperthermia in the treatment of chemoresistant tumors. Russian Journal of Oncology. 2003;3:50-3. (In Russ.).]
15. Курпешев О.К, Ван дер Зее Я., Кавагнаро М. Гипертермия опухолей глубокой локализации: возможности ёмкостного метода // Медицинская радиология и радиационная безопасность. 2019;64(4):64–75. DOI: 10.12737/1024-6177-2019-64-4-64-75. DOI: 10.12737 / 1024-6177-2019-64-4-64-75. [Kurpeshev OK, Van der Zee J, Kavagnaro M. Hyperthermia of Tumors of Deep Localization: Possibilities of the Capacitive Method. Medical Radiology and Radiation Safety. 2019;64(4):64-75. (In Russ.). DOI: 10.12737 / 1024-6177-2019-64-4-64-75]
16. Van der Heijden AG, Dewhirst MW. Effects of Hyperthermia in Neutralizing Mechanisms of Drug Resistance in Non-Muscleinvasive Bladder Cancer. Int J Hyperthermia. 2016;32(4):434-45. http://dx.doi.org/10.3109/ 02656736.2016.1155761
17. Курпешев ОК. Закономерности радиосенсибилизирующего и повреждающего эффектов гипертермии на нормальные и опухолевые ткани. Автореф. дисс. докт. мед. наук. Обнинск, 1989. 35 с. [Kurpeshev OK. Patterns of the radiosensitizing and damaging effects of hyperthermia on normal and tumor tissues. Author’s abstract. diss. PhD, MD. Obninsk, 1989. 35 pp. (In Russ.)]
18. Панкратов В.А., Андреев В.Г., Рожнов В.А., Гулидов И.А., Барышев В.В., Буякова М..Е, Вдовина С.Н., Курпешев О.К., Подлесных Н.И. Одновременное применение химио- и лучевой терапии при самостоятельном консервативном и комбинированном лечении больных местно-распространенным раком гортани и гортаноглотки // Сибирский онкологический журнал. 2007. № 1. С. 18-22. [Pankratov VA, Andreev VG, Rozhnov VA. Gulidov IA, Baryshev VV, Buyakova ME. Vdovina SN, Kurpeshev OK, Podlesnykh NI. Simultaneous Use of Chemotherapy and Radiation Therapy in Independent Conservative and Combined Treatment of Patients with Locally Advanced Cancer of the Larynx and Laryngopharynx. Siberian J. Oncology. 2007;1:18-22. (In Russ.).]
19. Van der Zee J, Vujaskovic Z, Kondo M, Sugahara T. Part I. Clinical Hyperthermia. The Kadota Fund International Forum 2004 − Clinical Group Consensus. Int J Hyperthermia. 2008;24(2):111-22.
20. Курпешев О.К., van der Zee J. Локорегионарная гипертермия злокачественных опухолей − методики, термометрия, аппаратура // Медицинская радиология и радиационная безопасность. 2017. 5(62). С. 52-63. DOI: 10.12737/article_59f30321207ef4.88932385. [Кurpeshev ОК, van der Zee J. Locoregional Hyperthermia of Malignant Tumors: Methods, Thermometry, Machines. Medical Radiology and Radiation Safety. 2017;62(5):52-63. (In Russ.). DOI: 10.12737/article_59f303 21207ef4.88932385]
21. Kouloulias V, Triantopoulou S, Vrouvas J, Gennatas K, Ouzounoglou N, Kouvaris J, Karaiskos P, Aggelakis P, Antypas C, Zygogianni A, Papavasiliou K, Platoni K, Kelekis N. Combined Chemoradiotherapy with Local Microwave Hyperthermia for Treatment of T3N0 Laryngeal Carcinoma: a Retrospective Study with Long-Term Follow-Up. Acta Otorhinolaryngol Ital. 2014;34(3):167-73. PMCID: PMC4035838.
22. Zhu H, Huo X, Chen L. Wang H, Yu H. Clinical Experience with Radio- Chemo- and Hyperthermotherapy Combined Trimodality on Locally Advanced Esophageal Cancer. Molecular and Clinical Oncology. 2013;1:1009-12. DOI: 10.3892/mco.2013.161.
23. Oldenborg S, van Os RM, Van Rij CM, Crezee J, van de Kamer JB, Rutgers E, Geijsen ED, Zum vörde sive vörding PJ, Koning CC, Van tienhoven G. Elective Re-Irradiation and Hyperthermia Following Resection of Persistent Locoregional Recurrent Breast Cancer: A Retrospective Study. Int J Hyperthermia 2010;26(2):136-44.
24. Oldenborg S, Griesdoorn V, van Os R, Kusumanto YH, Oei BS, Venselaar JL, Geijsen ED, Zum vörde sive vörding PJ, Koning CC, Van tienhoven G. Reirradiation and Hyperthermia for Irresectable Locoregional Recurrent Breast Cancer in Previously Irradiated Area: Size Matters. Radiother Oncol. 2015;117:223-28.
25. Oldenborg S, Rasch CRN, van Os R, Kusumanto YH, Oei BS, Venselaar JL, Heymans MW, ZumVörde Sive Vörding PJ, Crezee H, van Tienhoven G. Reirradiation + Hyperthermia for Recurrent Breast Cancer en Cuirasse. Strahlentherapie und Onkologie. 2018;194:206-14. https://doi.org/10.1007/s00066-017-1241-1247.
26. Linthorst M, van Geel AN, Baaijens M, Ameziane A, Ghidey W, van Rhoon GC, van der Zee J. Re-Irradiation and Hyperthermia After Surgery for Breast Cancer. Radiother. Oncol. 2013;109:188-93.
27. Linthorst M, Baaijens M, Wiggenraad R. Creutzberg C, Ghidey W, van Rhoon GC, van der Zee J. Local Control Rate after the Combination of Reirradiation and Hyperthermia for Irresectable Recurrent Breast Cancer: Results in 248 Patients. Radiother. Oncol. 2015;117:217-22.
28. Notter M, Thomsen AR, Nitsche M, Hermann RM, Wol HA, Habl G, Münch K, Grosu A-L, Vaupel P. Combined wIRA-Hyperthermia and Hypofractionated Re-Irradiation in the Treatment of Locally Recurrent Breast Cancer: Evaluation of Therapeutic Outcome Based on a Novel Size Classification. Cancers. 2020;12(3):606-20. DOI: 10.3390/cancers12030606.
29. Linthorst M, van Rhoon GC, van Geel AN, Baaijens M, Ghidey W, Broekmeyer-Reurink MP, van der Zee J. The Tolerance of Reirradiation and Hyperthermia in Breast Cancer patients with reconstructions. Int. J. Hyperthermia. 2012;28(3):267-77. DOI: 10.3109/02656736.2012.663951.
30. Roesch M, Mueller-Huebenthal B. Review: The Role of Hyperthermia in Treating Pancreatic Tumors. Indian J Surg Oncol. 2015 March; 6(1):75–81. DOI: 10.1007/s13193-014-0316-5.
31. Yanai Y, Yasoshima T, Fukui R, Shishido T, Ezoe E, Furuta Y, Morosawa H, Miya Y, Sato Y, Kondo M. Retrospective Analysis of Hyperthermia Therapy Y. in 47 case of Unresectable Pancreatic Cancer. The 6th Asian Congress of Hyperthermic Oncology & The 31st Japanese Congress of Thermal Medicine at Fukui City, Japan. September 5 (Fri.) − 6 (Sat.). 2014:146. Абстракт GSJ10.
32. Hetzel FW, Mattiello J. Interactions of Hyperthermia with Other Modalities. Medical Physics Monograph. Biological, Physical and Clinical Aspects of Hyperthermia (editors: Paliwal BR, Hetzel FW, Dewhirst MW). Am. Inst. Phys. 1987;16:30–56 (cit. according to [16]).
33. Franckena M, De Wit R, Ansink AC, Notenboom A, Canters RAM, Fatehi D, Van Rhoon GC, Van Der Zee J. Weekly Systemic Cisplatin Plus Locoregional Hyperthermia: An Effective Treatment for Patients with Recurrent Cervical Carcinoma in a Previously Irradiated Area. Int J Hyperthermia. 2007;23:443-50. DOI: 10.1080/02656730701549359.
34. Franckena M, Fatehi D, de Bruijne M, Canters RAM, van Norden Y, Mens JW, Van Rhoon GC, Van Der Zee J. Hyperthermia Dose-Effect Relationship in 420 Patients with Cervical Cancer Treated with Combined Radiotherapy and Hyperthermia. Eur J Cancer. 2009;45(11):1969-78. DOI: 10.1016/j.ejca.2009.03.009.
35. Jones E, Secord AA, Prosnitz LR, Samulski TV, Oleson JR, Berchuck A, Clarke-Pearson D, Soper J, Dewhirst MW., Vujaskovic Z. Intra-Peritoneal Cisplatin and Whole Abdomen Hyperthermia for Relapsed Ovarian Carcinoma. Int J Hyperthermia. 2006;22(2):161–72. DOI: 10.1080/02656730500515270.
36. Milani V, Pazos M, Issels RD, Rahman S, Tschoep K, Schaffer P, Wilkowski R, Duehmke E, Schaffer M. Radiochemotherapy in Combination with Regional Hyperthermia in Preirradiated Patients with Recurrent Rectal Cancer. Strahlentherapie und Onkologie. 2008;184(3):163-68. DOI: 10.1007/s00066-008-1731-8.
37. Ohguri T, Imada H, Kato F, Yahara K, Morioka T, Nakano K, Korogi Y. Radiotherapy with 8 MHz Radiofrequency-Capacitive Regional Hyperthermia for Pain Relief of Unresectable and Recurrent Colorectal Cancer. Int J Hyperthermia. 2006;22(1):1-14.
38. Курпешев О.К., Мардынский Ю.С., Максимов С.А. Комбинированное лечение больных раком полости рта с использованием "условно-динамического" режима фракционирования лучевой терапии и локо-регионарной гипертермии // Сибирское медицинское обозрение. 2011. 1(67). С. 80-84. DOI: 10.1080/02656730500381152. [Kurpeshev OK, Mardynsky YS, Maksimov SA. Combined Treatment of Patients with Oral Cancer Using the "Conditionally Dynamic" Mode of Fractionation of Radiation Therapy and Loco-Regional Hyperthermia. Siberian Medical Review. 2011;67(1):80-4. (In Russ.). DOI: 10.1080/02656730500381152]
39. Курпешев О.К., Андреев В.Г., Панкратов В.А., Гулидов И.А., Орлова А.В. Сравнительные результаты консервативной химиолучевой и термохимиолучевой терапии местнораспространенного рака гортани // Вопросы онкологии. 2014 № 5(60). С. 602-606. [Kurpeshev OK, Andreev VG, Pankratov VA, Gulidov IA, Orlova AV. Comparative Results of Conservative Chemoradiation and Thermochemoradiotherapy of Locally Advanced Laryngeal Cancer. Problems in Oncology. 2014;60(5):602-6. (In Russ.).]
40. Li Z, Sun Q, Huang X, Zhang J, Hao J, Li Y, Zhang S. The Efficacy of Radiofrequency Hyperthermia Combined with Chemotherapy in the Treatment of Advanced Ovarian Cancer. Open Med. 2018;13:83-9. https://doi.org/10.1515/med-2018-0013.
41. Курпешев О.К., Флоровская Н.Ю., Лебедева Т.В. Результаты паллиативной термохимиотерапии метастазов колоректального рака в печень // Вопросы онкологии. 2016. № 1(62). С. 85-90. [Kurpeshev ОК, Florovskaya NY, Lebedeva ТV. Results of Palliative Thermochemotherapy for Colorectal Cancer Metastases to the Liver. Problems in Oncology. 2016;62(1):85-90. (In Russ.).]
42. Yang W-H, Xie J, Lai Z-Y, Yang M-D, Zhang G-H, Li Y, Mu J-B, Xu J. Radiofrequency Deep Hyperthermia Combined with Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer. Chinese Medical J. 2019;132(8):922-7. DOI: 10.1097/CM9.0000000000000156. PMID: 30958433.
43. Maebayashi T, Ishibashi N, Aizawa T, Sakaguchi M, Sato T, Kawamori J, Tanaka Y. Treatment Outcomes of Concurrent Hyperthermia and Chemoradiotherapy for Pancreatic Cancer: Insights into the Significance of Hyperthermia Treatment. Oncology Letters. 2017;13:4959-64.
44. Merten R, Ott O, Haderlein M, Bertz S, Hartmann A, Wullich B, Keck B, Kühn R, Rödel CM, Weiss C, Gall C, Uter W, Fietkau R. Long-Term Experience of Chemoradiotherapy Combined with Deep Regional Hyperthermia for Organ Preservation in High-Risk Bladder Cancer (Ta, Tis, T1, T2). The Oncologist. 2019;24:1–10. www.TheOncologist.com.
45. Ott OJ, Schmidt M, Semrau S, Strnad V, Matzel KE, Schneider I, Raptis D, Uter W, Grützmann R, Fietkau R. Chemoradiotherapy with and without Deep Regional Hyperthermia for Squamous Cell Carcinoma of the Anus. Strahlentherapie und Onkologie. 2019;195(7):607-14. DOI: 10.1007/s00066-018-1396-x
46. Cho C, Wust P, Hildebrandt B, Issels RD, Sehouli J, Kerner T, Deja M, Budach V, Gellermann J. Regional Hyperthermia of the Abdomen in Conjunction with Chemotherapy for Peritoneal Carcinomatosis: Evaluation of Two Annular-Phased-Array Applicators. Int J Hyperthermia. 2008;24(5):399-408. DOI: 10.1080/02656730801929915.
47. Shen H, Li X-D, Wu C-P, Yin Y-M, Wang R-S, Shu Y-Q. The Regimen of Gemcitabine and Cisplatin Combined with Radio Frequency Hyperthermia for Advanced Non-Small Cell Lung Cancer: A Phase II Study. Int J Hyperthermia, February 2011;27(1):27-32. DOI: 10.3109/02656736.2010.500645.
48. Kурпешев O.K., van der Zee J. Анализ результатов рандомизированных исследований по гипертермии в онкологии // Медицинская радиология и радиационная безопасность. 2018. № 3(63). С. 52-67. DOI: 10.12737/article_5b179d60437d54.24079640. [Kurpeshev OK, van der Zee J. Analysis of the Results of Randomized Trials of Hyperthermia in Oncology. Medical Radiology and Radiation Safety. 2018;63(3):52-67. (In Russ.). DOI: 10.12737/article_5b179d60437d54.24079640]
49. Chi MS, Yang KL, Chang YC, Ko H-L, Lin Y-H, Huang S-C, Huang Y-Y, Liao K-W, Kondo M, Chi K-H. Comparing the Effectiveness of Combined External Beam Radiation and Hyperthermia Versus External Beam Radiation Alone in Treating Patients With Painful Bony Metastases: A Phase 3 Prospective, Randomized, Controlled Trial. Int J Rad Oncol Biol Phys. 2018;100:78-87. DOI: 10.1016/j.ijrobp.2017.09.030.
50. Li G-X, Lu Z, Sun X-M, Ma C-G., Liu K., Liu J, Guo L, Li P-X. Clinical Effect of Radiofrequency Hyperthermia Combined with Chemotherapy on Stage IV Gastric Cancer. Chinese J. of Cancer Prevention and Treatment. 2010;17:526-28.
51. Fang H, Zhang Y, Wu Z, Wang X, Wang H, Wang Y, Chai F, Jiang Y, Jin Z, Wan Y, Zhu L, Ma S. Regional Hyperthermia Combined with Chemotherapy in Advanced Gastric Cancer. Open Med. 2019;14:85-90. https://doi.org/10.1515/med-2019-0012.
52. Wang Y, Hong W, Che S, Zhang Y, Meng D, Shi F, Su J, Yang Y, Ma H, Liu R, Gao Y, Wang J, Hui B, Wang J, Lu J, Wang T, Liu Z, Chen H. Outcomes for Hyperthermia Combined with Concurrent Radiochemotherapy for Patients with Cervical Cancer. Int J Rad Oncol Biol Phys. Published: March 13, 2020. DOI: 10.1016/j.ijrobp.2020.03.006
53. Datta NR, Pestalozzi B, Clavien P-A, Siebenhüner A, Puric E, Khan S, Mamot C, Riesterer O, Knuchel J, Reiner CS, Bodis S and members of the HEATPAC Trial Group. “HEATPAC J.” – A Phase II Randomized Study of Concurrent Thermochemoradiotherapy Versus Chemoradiotherapy Alone in Locally Advanced Pancreatic Cancer. Radiation Oncology. 2017;12:183. DOI: 10.1186/s13014-017-0923-8.
54. Datta NR, Rogers S, Ordóñez SG, Puric E, Bodis S. Hyperthermia and Radiotherapy in the Management of Head and Neck Cancers: A Systematic Review and Meta-Analysis. Int J Hyperthermia. 2016;32(1):31-40. DOI: 10.3109/02656736.2015.1099746.
55. Datta NR, Puric E, Klingbiel D, Gomez S, Bodis S. Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A SystematicReview and Meta-analysis. Int. J. Radiat. Oncol. Biol. Phys. 2016; 94:1073-87. DOI: https://doi.org/10.1016/j.ijrobp.2015.12.361.
56. Datta NR, Rogers S, Klingbiel D, Gómez S, Puric E, Bodis S. Hyperthermia and Radiotherapy with or without Chemotherapy in Locally Advanced Cervical Cancer: A Systematic Review with Conventional and Network Meta-Analyses. Int J Hyperthermia. 2016;32(7):809-21. DOI: 10.1080/02656736.2016.1195924.
57. Baoning Q, Chuandao S, Na S, Xinan W, Yuanping H. Efficacy and Safety of Radio-Chemotherapy Combined with Thermotherapy for Advanced Cervical Cancer in Chinese Women: A Meta-Analysis. Arch. Med. Sci. Civil. Dis. 2017;2:e182–e90. DOI: https://doi.org/10.5114/amscd.2017.72542.
58. Hu Y, Li Z, Mi D.-H, Cao N, Zu S-W, Wen Z.-Z, Yu X-L, Qu Y. Chemoradiation Combined with Regional Hyperthermia for Advanced Oesophageal Cancer: A Systematic Review and Meta-Analysis. Journal of Clinical Pharmacy and Therapeutics. 2017;42:155-64. DOI: 10.1111/jcpt.12498.
59. Курпешев О.К., Цыб А.Ф., Мардынский Ю.С., Бердов Б.А. Механизмы развития и пути преодоления химиорезистентности опухолей. Часть 3. Возможные пути преодоления химиорезистентности опухолей // Российский онкологический журнал. 2003. № 2. С. 50-52. [Kurpeshev OK, Tsyb AF, Mardynsky YS, Berdov B.A. Mechanisms of development and ways of overcoming the chemoresistance of tumors. Part 3. Possible ways to overcome tumor chemoresistance. Russian Journal of Oncology. 2003;2:50-2. (In Russ).]
60. Курпешев ОК, Van der Zee J. Экспериментальные основы применения гипертермии в онкологии // Медицинская радиология и радиационная безопасность. 2018. № 1(63). С. 57-77. DOI: 10.12737/article_5a8556b4be3e24.36808227. [Kurpeshev OK, Van der Zee J. The Experimental Basis for the Use of Hyperthermia in Oncology. Medical Radiology and Radiation Safety. 2018;63(1):57-77. (In Russ.). DOI: 10.12737/article_5a8556b4be3e24.36808227. (In Russ)]
61. Oei AL, Vriend LEM, Krawczyk PM, Horsman MR, Franken NAP, Crezee J. Targeting Therapy–Resistant Cancer Stem Cells by Hyperthermia. Int J Hyperthermia. 2017;33(4):419-27. DOI: 10.1080/02656736.2017.1279757.
62. Pelicci PG, Dalton P, Orecchia R. Heating Cancer Stem Cells to Reduce Tumor Relapse. Breast Cancer Research. 2011;13:305. DOI: https://doi.org/10.1186/bcr2847.
63. Sakurai H. Tumor Targeting with Hyperthermia. Jpn J Hyperthermic Oncology. 2006;22(2):61-9.
64. Curley SA, Palalon F, Sanders KE, Koshkina NV. The Effects of Non-Invasive Radiofrequency Treatment and Hyperthermia on Malignant and Nonmalignant Cells. Int. J. Environ Res. Public Health. 2014;11(9):9142–53. DOI: 10.3390/ijerph110909142.
