УДК 577

Electron Probe Microanalysis: Na+/K+-ATPase, Strophanthin and Cardiac Ischemia

Опубликовано в АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ · Том 2, Номер 1, 2017 · Страницы 34–36 · Рубрики: Общая биофизика
Получено: 20.06.2017 Одобрено: 20.06.2017 Опубликовано: 25.06.2017 Язык публикаций: ENG
Авторы
1 Institute of Theoretical and Experimental Biophysics, RAS
2 Institute of Theoretical and Experimental Biophysics, RAS
3 Institute of Theoretical and Experimental Biophysics, RAS
Electron probe microanalysis was applied to study the kinetics of changes in potassium and sodium concentration in muscle cells of isolated heart from Wistar rat during experimental ischemia. Hypoxic perfusion without glucose was shown to evoke the potassium deficiency and sodium accumulation in cardiac myocells. Short_term action (10 min) of strophanthin (0.1 mM/l) recovered Na/K balance in ischemic myocells.
Electron Probe Microanalysis (EPMA) cardiac ischemia myocell cytoplasmic K/Na balance Na+/K+- ATPase strophanthin
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Список литературы

1. Pogorelov A.G., Rusakov A.V., Pogorelova V.N. Cytoplasmic Potassium-Sodium Balance in the Cardiac Muscle Cell of Young and Old Rats in Oxygen-Substrate Deficiency. Biophysics, 2006, vol. 51, no. 5, pp. 752-757.

2. Pogorelov A.G., Pogorelova V.N., Dubrovkin M.I., Demin I.P., Khrenova E.V. Activation of specific membrane mechanisms of a cardiomyocyte at the initial stages of ischemia. Biophysics, 2002, vol. 47, no. 2, pp. 744-751.

3. Pogorelov A.G., Pogorelova V.N., Pogorelova M.A. Does an electro neutral K+/Cl- antiport occur in cardiomyocyte during acute ischemia? Biophysics, 2010, vol. 55, no. 5, pp. 771-774.

4. Pierce G.N., Czubryt M.P. The contribution of ionic imbalance to ischemia/reperfusion-induced injury. J. Mol. Cell. Cardiol., 1995, vol. 27, pp. 53-63.

5. Therien A.G., Blostein R. Mechanisms of sodium pump regulation. Am. J. Physiol., 2000, vol. 279, pp. C541-C 566.

6. Balazs I. Effects of cardiotoxic agents on the electrical properties of myocardial cells. Cardiac Toxicology, 1981, vol. 1, pp. 39-48.

7. Pribe L., Friedrich M., Benndorf K. Functional interactions between KATP channels and the Na+-K+ pump in metabolically inhibited heart cells of the guinea-pig. J. Physiol., 1996, vol. 492, pp. 405-417.

8. Pogorelov A.G., Pogorelova V.N., Khrenova E.V., Dubrovkin M.I., Demin I.P. The role of “sleeping” mechanisms in regulation of K/Na-balance in the rat cardiac muscle cell during hypoxia. J Evol. Biochem. Phisiol., 2004, vol. 40, pp. 353-358.

9. Lindinger M.I. Potassium regulation during exercise and recovery in humens: implications for sceletal and cardiac muscle. J. Mol. Cell. Cardiol., 1995, vol. 27, pp. 1011-1022.

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