from 01.01.2020 until now
All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology of the Russian Academy of Agricultural Sciences ( sotrudnik)
Russian Federation
Purpose of the research — to conduct analysis of the status and perspective of application of prolonged forms of anthelmintic drugs in veterinary. Materials and methods. On the topic of development and application of prolonged forms of anthelmintic in veterinary was conducted the analysis of 27 literature sources including 23 foreign authors. Were analyzed the data about kinetics of avermectins and praziquantel in the animals body and comparative results about dependence and correlation of pharmacokinetic parameters with their anthelmintics efficiency. The results and discussion. Prolonged forms of avermectins which prevent the infections for long period are developing to prevent infection of animals during grazing season. Attempts to create prolonged dosage forms of praziquantel to prevent the Schistosoma japonicum infections are currently in progress. Was shown the possibility of obtaining polymeric microspheres, which contains ivermectins in the form of implants. As solvents are used N-methylpyrrolidone, triacetin, benzyl benzoate etc. Mixes of composite based on sucrose, acetate isobutyrate and polylactic acid is offered for prolongation of the action of ivermectin, which is provides release of ivermectin within 80 days. Were described prolonged forms of praziquantel as the implants on a base of polycaprolactone and it’s mix with polyethylene glycol, which is obtained by extrusion of a melt of a mixture of praziquantel and polymers.
ivermectins, praziquantel, prolonged forms, implants, kinetics, efficiency, helminthosis.
Широкое распространение гельминтозов наносит огромный экономический ущерб животноводству из-за падежа животных, недополучения мясной и молочной продукции. К числу наиболее распространённых паразитозов среди овец и крупного рогатого скота относят дикроцелиоз, фасциолёз, диктиокаулез, мониезиоз и стронгилятозы пищеварительного тракта. Максимальную зараженность животных гельминтами отмечают в конце лета и осенью [3, 4]. Лечением животных при гельминтозах стали заниматься с тех пор, как были установлены болезни, вызываемые гельминтами [1].
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