MECHANISMS OF DEDIFFERENTIATION OF NON-LIGHT BREAST CANCER CELLS TO STEM CELLS
Authors:
Type:
Сonference abstract
Published:
16.02.2023
Subject area:
UDK 61 Медицина. Охрана здоровья. Пожарное дело
Language:
Russian
Keywords:
breast cancer, dedifferentiation, metastasis, tumor stem cells, mammospheres, stem genes, gene inhibitors
Funding:
Rabota podderzhana grantom RNF № 21-15-00243
Abstract (English):
It is known that the ability to dedifferentiate in non-stem cells causes its malignancy and its ability to metastasize [1]. The lack of a tendency to dedifferentiate and detect the affected stem phenotype explains the inability to metastasize within one localization. Previously, we found that the acquisition of the ability to dedifferentiate is a marker of tumor growth to metastasis. This process occurs during ectopic expression of stemness genes due to amplification of their loci in different chromosomes of tumor cells. For the presence of clinical material, it was found that even more amplifications of two chromosomes in the residual rise is associated with a high frequency of metastasis [2]. Thus, the result of the work was the observation of the regulation of the regulation of dedifferentiation of tumor non-stem cells in tumor stem cells in in vitro models.
It is known that the ability to dedifferentiate in non-stem cells causes its malignancy and its ability to metastasize [1]. The lack of a tendency to dedifferentiate and detect the affected stem phenotype explains the inability to metastasize within one localization. Previously, we found that the acquisition of the ability to dedifferentiate is a marker of tumor growth to metastasis. This process occurs during ectopic expression of stemness genes due to amplification of their loci in different chromosomes of tumor cells. For the presence of clinical material, it was found that even more amplifications of two chromosomes in the residual rise is associated with a high frequency of metastasis [2]. Thus, the result of the work was the observation of the regulation of the regulation of dedifferentiation of tumor non-stem cells in tumor stem cells in in vitro models.
Keywords:
breast cancer, dedifferentiation, metastasis, tumor stem cells, mammospheres, stem genes, gene inhibitors
breast cancer, dedifferentiation, metastasis, tumor stem cells, mammospheres, stem genes, gene inhibitors
1. Hanahan D. Hallmarks of cancer: new dimensions //Cancer discovery. – 2022. – V. 12. – №. 1. – P. 31-46.
2. Litviakov N. V. et al. Somatic-stem transition of tumor cells is a key link in the metastasis // Annals of Oncology. 2018. V.29. P. VIII682.
