Objective: To study the contribution of xenobiotic biotransformation enzyme genes, transcription factors, inflammatory and immune response receptors in determining health deficiency in the separated period after cardiac surgery for congenital heart disease. Materials and methods. 116 children who underwent radical correction of CHD were examined. An assessment of the catamnesis of these children and genetic typing of genes encoding enzymes for the biotransformation of xeno- and endobiotics (GSTP, CYP1A2, CYP1A1), involved in the determination of cardiogenesis and processes in cardiomyocytes (CRELD-1, GATA-6, NOTCH-1), innate ( TREM-1) and adaptive (HLA-DR) immunity. The search for predictors of functioning deficit by physical, psycho-emotional, social, mental types was carried out using multiple logistic regression. Results. The level of functioning of various components of health one year after surgical treatment was associated with the same factors. These factors negatively affecting the health of children one year after heart surgery were: unfavorable living conditions, as well as genetic predictor markers HLA-DRB1*07 and Creld1 T/C (rs9878047)*T.
congenital heart disease, CRELD1, HLADRB1, housing conditions
1. Warnes C.A., Liberthson R., Danielson G.K., Dore A., Harris L., Hoffman J.I., Somerville J., Williams R.G., Webb G.D. Task force 1: the changing profile of congenital heart disease in adult life. J. Am. Coll. Cardiol., 2001, vol. 37, no. 5, pp. 1170 –1175. DOI: 10.1016/s0735-1097(01)01272-4.
2. Chen, L., Guan, J., Wei, Q., Yuan, Z., & Zhang, M. (2018). Potential role of “omics” technique in prenatal diagnosis of congenital heart defects. Clinica Chimica Acta, 482, 185-190.
3. Khaitov R.M., Alexeev L.P., Kofiadi I.A. Role of immunogenetics in addressing fundamental and applied tasks of personalized medicine. Meditsina ekstremal’nyh situatsii, 2016, vol. 3, no. 57, pp. 9–24 (in Russian).
